A review.The marine pharmacol. research is getting stronger and stronger.Recent research has focused on the study of specific activity of marine natural products, and applied to new drugs for human.Phloroglucinol is a kind of important pharmaceutical intermediates.It is widely distributed in marine alga, especially in Phaeophyta.As a non-atropine non-papaverine class smooth muscle spasmolysis medicine, phloroglucinol primarily treat a variety of acute spasmodic pain.It is the first chosen drug in the treatment of gastrointestinal, genitourinary tract spasms and contractions during pregnancy, for its fast-acting, less side effects.Now, phloroglucinol is mainly produced by chem. synthesis.But the chem. method has many disadvantages, so biol. synthesis become a potential method and research hot spot to produce phloroglucinol.The mechanisms and the methods of phloroglucinol biosynthesis are reviewed.In addition, it also sums up the main applications of phloroglucinol.