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Neoplasms

Small molecule drug

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Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1

Top 5 Target	Count

KIF11(Kinesin-like protein 1)	1

ETHNOPHARMACOLOGICAL RELEVANCESaffron is derived from the dried stigmas of Crocus sativus L., which was considered by ancient nations for food and medicinal purposes. In traditional medicine, the therapeutic use of Crocus sativus includes antispasmodic, antitussive and expectorant.AIM OF THE STUDYMitochondrial fusion, fission, biogenesis, and mitophagy are essential processes for maintaining mitochondrial dynamics in response to cellular stress. The primary objective of this research was to examine how crocin affected the levels of important mitochondrial regulators, including Drp1, Pgc1α, Nrf1, and Mfn2, in the lung tissue of ovalbumin-sensitized mice.MATERIALS AND METHODSA total of fifty male BALB/C mice were randomly assigned to five unique groups (n = 10 for each group), including the control group, ovalbumin-sensitized group (OVA), OVA group treated with 30 mg/kg of crocin, OVA group treated with 60 mg/kg of crocin, and OVA group treated with 1 mg/kg of dexamethasone. Post-sensitization and ovalbumin challenge, mice lung tissues were evaluated for the expression of Drp1, Pgc1α, Nrf1, and Mfn2 mRNA levels using real-time PCR as well as histopathological assessments.RESULTSIn the OVA group, there was a significant elevated in inflammatory cells such as eosinophils, neutrophils, macrophages, and lymphocytes; however, crocin (both concentrations) and dexamethasone intervention showed significant inhibitory effects (P < 0.01 to P < 0.001). Moreover, an increase in the expression of Drp1, Pgc1α, and Nrf1 levels was seen in the OVA group, while crocin and dexamethasone showed protective benefits (P < 0.05 to P < 0.001). Furthermore, the levels of Mfn2 were reduced in the lung tissue of mice exposed to ovalbumin, but this decrease was reversed by crocin 60 (P < 0.05) and dexamethasone treatment (P < 0.001).CONCLUSIONIn mice with OVA sensitization, the balance of mitochondrial dynamics in lung tissue was disrupted, but intervention of crocin identified to have a protective effect.

01 Jan 2025·Talanta

Recent advances in receptor-based optical biosensors for the detection of multiplex biomarkers

Review

Author: Fathi, Farzaneh ; Samadi, Hamed ; Samadi Pakchin, Parvin ; Pakchin, Parvin Samadi ; Adibkia, Khosro

Multiplex biosensors are highly sought-after tools in disease diagnosis. This technique involves the simultaneous sensing of multiple biomarkers, whose levels and ratios can provide a more comprehensive assessment of disease conditions compared to single biomarker detection. In most diseases like cancer due to its complexity, several biomarkers are involved in their occurrence. On the other hand, a single biomarker may be implicated in various diseases. Multiplex sensing employs various techniques, such as optical, electrochemical, and electrochemiluminescence methods. This comprehensive review focuses on optical multiplex sensing techniques, including surface plasmon resonance, localized surface plasmon resonance, fluorescence resonance energy transfer, chemiluminescence, surface-enhanced Raman spectroscopy, and photonic crystal sensors. The review delves into their mechanisms, materials utilized, and strategies for biomarker detection.

01 Jan 2025·Archives of academic emergency medicine

Diagnostic Value of Chest Computed Tomography Scan for Identification of Foreign Body Aspiration in Children: A Systematic Review and Meta-analysis.

Review

Author: Ajami, Negar ; Mohammadi Visroud, Mozhdeh ; Hosseini, Zahrasadat ; Mirbolook, Amirhossein ; Momeni, Zahra ; Manavi, Mahdokht Sadat ; Zahedpasha, Reza ; Hoorshad, Behnam ; Fallahian, Amirali ; Goodarzy, Babak ; Alipour Khabir, Yalda ; Moghadam Fard, Atousa ; Safdari, Sina ; Tavakoli, Reza ; Seifi, Sepideh ; Ranjbar, Ehsan ; Najafi, Aboulfazl ; Afrazeh, Fatemeh ; Momeni, Hamidreza ; Jalayeri, Hediyeh ; Azimi, Habib ; Mahjoubi, Mohammad ; Kahrizi, Mohammad Saeed ; Amani Beni, Reza ; Ghalichebaf Yazdi, Yeganeh ; Rahmani, Erfan ; Aboulhassanzadeh, Sobhan ; Ghadirzadeh, Erfan ; Esmaili Jobani, Alireza ; Bakhtiyari, Paria ; Ramezani, Sahel ; Hosseini, Mohammad Hossein ; Zare Lahijan, Lida ; Atighi, Javaneh ; Alipour Khabir, Sevda ; Tavakoli, Mehdi ; Farrokhi, Mehrdad ; Ranjbaran Ghaleh, Mohadese

IntroductionForeign body aspiration (FBA) is a common, life-threatening pediatric emergency and was shown to be associated with high risk of morbidity and mortality. This systematic review and meta-analysis aimed to investigate the diagnostic value of chest computed tomography (CT) scan for identification of FBA in children.MethodsFrom inception to May 2024, a systematic search was carried out across multiple databases including Medline, Scopus, and Web of Science, considering published papers in English language. Quality assessment of the included studies was performed using seven domains of Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2).ResultsThe systematic literature search yielded 7203 articles. The pooled sensitivity and specificity of chest CT scan for identification of FBA were 0.99 (95% CI: 0.98-0.99) and 0.97 (95% CI: 0.96-0.98), respectively. The pooled positive likelihood ratio was 10.12 (95% CI: 4.59-22.20), and pooled negative likelihood ratio was 0.05 (95% CI: 0.02-0.1). Furthermore, the area under the summarized receiver operating characteristic (SROC) curve was 0.98.ConclusionOur meta-analysis revealed that despite high heterogeneity, in the diagnostic characteristics of chest CT scan among studies, it has high diagnostic value in identifying FBA in suspected pediatric cases.

100 Deals associated with Ardabil University of Medical Sciences

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Pipeline

Pipeline Snapshot as of 27 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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