Investigation of effectiveness of inhalation intake of beta-caryophyllene (BCP) against vascular wall stiffening caused by smoking. - Investigation of effectiveness of inhalation intake of beta-caryophyllene (BCP) against vascular wall stiffening caused by smoking.

Start Date10 Dec 2022

Sponsor / Collaborator

Sunsho Pharmaceutical Co., Ltd.

JPRN-UMIN000048512 / Completed

Blood transfer confirmation test of beta-caryophyllene by single inhalation ingestion associated with smoking of beta-caryophyllene - Blood transfer confirmation test of beta-caryophyllene by single inhalation ingestion associated with smoking of beta-caryophyllene

Start Date01 Dec 2021

Sponsor / Collaborator

Sunsho Pharmaceutical Co., Ltd.

JPRN-UMIN000048510 / Completed

Randomized controlled trials to verify that inhalation of beta-caryophyllene improves vascular wall hardening and lowers baPWV - Randomized controlled trials to verify that inhalation of beta-caryophyllene improves vascular wall hardening and lowers baPWV

Start Date01 Sep 2021

Sponsor / Collaborator

Sunsho Pharmaceutical Co., Ltd.

100 Clinical Results associated with Sunsho Pharmaceutical Co., Ltd.

0 Patents (Medical) associated with Sunsho Pharmaceutical Co., Ltd.

Literatures (Medical) associated with Sunsho Pharmaceutical Co., Ltd.

01 Jan 2024·Journal of Oleo Science

Beneficial Effects of a Formulated Supplement of Ascidiacea (<i>Halocynthia-roretzi</i>)-derived Plasmalogen and Tuna-derived Elastin on Memory Function in Elderly Japanese Subjects; A Randomized, Double-blind, Placebo-controlled Study

Article

Author: Matahira, Yoshiharu ; Kurono, Masahiro ; Ono, Ken ; Yamada, Shizuo ; Shirai, Michiyo ; Kageyama, Shinji ; Katsumata, Masahiro

The beneficial effects of a formulated supplement of plasmalogen and elastin on the memory function in healthy elderly subjects were investigated by a randomized, double-blind, placebo-controlled, parallel-group analysis. Plasmalogen has been shown to exert beneficial effects on cognitive function in animal models and human clinical trials, while elastin improves vascular elasticity and increases blood flow. The levels of plasmalogen and elastin decreases with aging. The supplement containing Ascidiacea (Halocynthia-roretzi)-derived plasmalogen (0.5 mg) and Tuna-derived elastin (100 mg) was administered to elderly Japanese subjects once a day for 16 weeks. The Japanese version of Rivermead Behavioral Memory Test (RBMT) was used as a primary evaluation item for the assessment of memory. Data from a protocolmatched population (per protocol set) (n=123) were analyzed. A comparison of mean difference between the baseline and evaluation points in cognition function in RBMT showed significantly higher scores for the categories of "first name" and "face recognition" in the test group than in the placebo group. In the stratified analysis of subjects ≧ 75 years, the test group scored significantly higher than the placebo group for the categories of "belonging", "face recognition and picture recognition". The stratified analysis of female subjects showed a significantly higher scores for categories of "first and second names" and "belonging" of RBMT in the test group. Also, the score of "physical functioning" was significantly higher in the test group. These results indicate that formulated supplement of plasmalogen and elastin may be beneficial for improving memory dysfunction in healthy elderly subjects.

01 Sep 2022·Biomedicine & Pharmacotherapy

Inhaled volatile β-caryophyllene is incorporated into the aortic wall and attenuates nicotine-induced aorta degeneration via a CB2 receptor-dependent pathway

Article

Author: Higashihara, Mayo ; Moriyama, Tatsuya ; Zaima, Nobuhiro ; Matsumura, Shinichi ; Yoshioka, Yuri ; Kishi, Chihiro ; Yamada, Kazuya ; Takemoto, Yuki ; Kamei, Moeka ; Matahira, Yoshiharu ; Kobayashi, Takanori

β-caryophyllene (BCP) is a volatile bicyclic sesquiterpenoid found in essential oils obtained from several spices such as black pepper, oregano, basil, rosemary, cinnamon, and clove. BCP is a selective agonist of cannabinoid receptor 2 (CB2 receptor), and orally administered BCP exhibits various biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. However, it is still unclear how volatile BCP affects living organisms. We previously reported that inhaled BCP is transferred to sera and organs in mice; additionally, metabolomic analysis revealed inhaled BCP affect the dynamics of metabolites in the livers of mice. These data suggest that inhaled BCP may affect several biological activities by stimulating biological systems. In this study, we evaluated the effects of BCP inhalation on nicotine-induced degeneration of the aortic wall. In the group of mice which inhaled volatile BCP, nicotine-induced increases in elastic fiber degradation and matrix metalloproteinase-2 (MMP-2)-positive areas were attenuated. In addition, BCP improved the nicotine-induced stiffness of aortae and vulnerability to aortic rupture. In cultured aortae, the suppressive effects of BCP were inhibited by the CB2 receptor inhibitor AM630. These results suggest that inhaled BCP is incorporated into the aortic wall and prevents nicotine-induced degeneration of the aorta via a CB2 receptor-dependent pathway.

01 Mar 2020·Pharmaceutical Research

UniORV, a New Multi-Unit Dosage Form, Improved Biopharmaceutical Properties of Tacrolimus in Rats and Humans

Article

Author: Hirasawa, Wataru ; Mineda, Misuzu ; Tsukada, Ryota ; Matahira, Yoshiharu ; Sato, Hideyuki ; Onoue, Satomi ; Sei, Shunsuke ; Endo, Norimasa ; Makino, Keisuke

PURPOSEThe aim of the present study was to develop a new multi-unit dosage formulation, Universal ORbicular Vehicle (UniORV), to improve the biopharmaceutical properties of tacrolimus (TAC).METHODSTAC-loaded UniORV (UO/TAC) was produced by the dripping and gelling of a solution comprising TAC, gelatin, starch syrup, and triethyl citrate at 0.5 w/w% drug loading. Its microstructure was elucidated by polarized light microscopy and the Raman mapping technique. The pharmacokinetic profiles of TAC after the oral administration of UO/TAC were evaluated in rats and healthy humans.RESULTSThe dissolution behavior of UO/TAC was similar to that of commercial capsules, and the formation of nanoparticles was detected by TEM in dissolved media. In a stability study on UO/TAC, only 2.6 and 4.7% decreases in TAC concentrations were observed at 40± 2°C/75 ± 5% relative humidity for 4 months and at 50± 2°C for 2 months, respectively. A pharmacokinetic study on rats revealed a 30-fold higher AUC than that with crystalline TAC. A randomized double-blind crossover study on 8 healthy males showed that UniORV achieved a 1.4-fold increase in AUC and 34% decrease in inter-individual variation from the reference formulation.CONCLUSIONThe new dosage form UniORV is a promising approach to improve the dissolution, amorphous stability, and biopharmaceutical properties of TAC, which is a poorly water-soluble drug.

100 Deals associated with Sunsho Pharmaceutical Co., Ltd.

100 Translational Medicine associated with Sunsho Pharmaceutical Co., Ltd.

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