Delving into the Latest Updates on Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc. with Synapse

Overview

Tags

Endocrinology and Metabolic Disease

Cardiovascular Diseases

Infectious Diseases

Recombinant polypeptide

Chemical drugs

Biosimilar

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	1
Infectious Diseases	1

Top 5 Drug Type	Count

Biosimilar	1
Recombinant polypeptide	1
Chemical drugs	1

Top 5 Target	Count

30S subunit(30S ribosomal subunit)	1
GLP-1R(Glucagon-like peptide 1 receptor)	1

1、评估司美格鲁肽注射液与原研司美格鲁肽注射液Wegovy®相比，在成人肥胖受试者中作为减少热量饮食和增加体力活动的辅助治疗的有效性； 2、评估司美格鲁肽注射液与Wegovy®相比，体重相对基线下降百分比≥5%的受试者比例和对腰围的影响；评估司美格鲁肽注射液与Wegovy®相比的安全性和耐受性。

[Translation]

1. To evaluate the effectiveness of semaglutide injection as an adjunct to reduced-calorie diet and increased physical activity in adult obese subjects compared with the original semaglutide injection Wegovy®; 2. To evaluate the proportion of subjects with a weight loss of ≥5% relative to baseline and the effect on waist circumference compared with semaglutide injection and Wegovy®; to evaluate the safety and tolerability of semaglutide injection compared with Wegovy®.

Start Date13 Sep 2024

Sponsor / Collaborator

Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

CTR20222962

/ CompletedPhase 3

司美格鲁肽注射液与诺和泰®在2型糖尿病患者中多中心、随机、开放、平行对照的临床有效性和安全性对比试验。

[Translation] A multicenter, randomized, open, parallel-controlled comparative trial of the clinical efficacy and safety of semaglutide injection and Novotel® in patients with type 2 diabetes.

评价司美格鲁肽注射液与诺和泰®在2型糖尿病患者中多次给药的降糖疗效临床等效性，并比较安全性。

[Translation]

To evaluate the clinical equivalence of the glucose-lowering efficacy of semaglutide injection and Novotel® after multiple administration in patients with type 2 diabetes, and to compare their safety.

Start Date12 Jan 2023

Sponsor / Collaborator

Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

CTR20222452

/ CompletedPhase 1

司美格鲁肽注射液与诺和泰®在健康受试者中单次给药、随机、开放、平行对照的药代动力学对比试验

[Translation] A single-dose, randomized, open-label, parallel-controlled pharmacokinetic comparison study between semaglutide injection and Novotec® in healthy subjects

主要目的：评价受试制剂司美格鲁肽注射液和参比制剂司美鲁肽注射液（诺和泰®）在健康受试者中单次给药的生物等效性，并比较二者的药代动力学特征次要目的：评价司美格鲁肽注射液在健康受试者中单次给药的安全性

[Translation]

Primary objective: To evaluate the bioequivalence of the test preparation semaglutide injection and the reference preparation semaglutide injection (Novotai®) in healthy subjects after a single dose, and to compare the pharmacokinetic characteristics of the two. Secondary objective: To evaluate the safety of a single dose of semaglutide injection in healthy subjects.

Start Date29 Dec 2022

Sponsor / Collaborator

Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

100 Clinical Results associated with Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

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0 Patents (Medical) associated with Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

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2

Literatures (Medical) associated with Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

Weishengwu Qianyan

Laser mutation and combined antibiotics resistance selection to daptomycin producing strains

Author: Wu, Qiuping ; Chen, Ping ; Jiang, Yongfei

In this paper, He-Na laser irradiation and antibiotics resistance selection method were used to screen daptomycin high-producing strains.He-Na laser irradiation was applied to screen daptomycin high-producing strain from original strain of Streptomyces roseosporus DA15-2.The optimum mutagenesis dose was irradiation power 20 mW and irradiation time for 20 min, which was determined based on survival rate and pos. mutation rate.The mutant strains on the plates of combined antibiotics resistance of daptomycin and Streptomyces at different concentrations were screened and a mutant strain DA15-23 was obtained, whose yield of daptomycin was 100 mg/L, which increased 75.8% compared to that of the parental strain.It was demonstrated that laser irradiation and antibiotics resistance selection combined method provided a fast and effective way of screening Streptomyces roseosporus.

CrystEngComm

Solubility, crystallization process optimization, and thermal properties of afoxolaner and the single-crystal structure of its hydrate

Author: Zhou, Lingyu ; Wu, Shu-Ting ; Chen, Li ; Chen, Xinyao ; Xiao, Wang-Dong ; Sun, Chong ; Lu, Qiaomei ; Fang, Zong-Bin ; Xiao, Yue-Feng

As an emerging isoxazoline insecticide, afoxolaner has a good effect in the prevention and treatment of canine parasite infections. In this work, the solubility and crystallization process were studied, as well as a crystal structure of its hydrate.

100 Deals associated with Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

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100 Translational Medicine associated with Livzon Group Xinbeijiang Pharmaceutical Manufacturing Inc.

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Pipeline

Pipeline Snapshot as of 23 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

NDA/BLA

1

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Sisomicin sulfate ( 30S subunit )	Infectious Diseases More	Approved
Semaglutide biosimilar (Livzon Group) ( GLP-1R )	Diabetes Mellitus, Type 2 More	NDA/BLA