Kunming Bangyu Pharmaceutical Co., Ltd.

The main purpose of the study is to study the pharmacokinetic characteristics of the test preparation tetrafenone soft capsule (specification: 15 mg, licensee: Kunming Bangyu Pharmaceutical Co., Ltd.) and the reference preparation tetrafenone soft capsule (Gulikang®, specification: 15 mg, licensee: Eisai Co., Ltd.) in healthy subjects after a single oral administration in the fasting and fed state, and to evaluate the bioequivalence of the two preparations in the fasting and fed state. Secondary purpose of the study is to evaluate the safety of the test preparation tetrafenone soft capsule (specification: 15 mg) and the reference preparation tetrafenone soft capsule (Gulikang®, specification: 15 mg) in healthy subjects.

Main purpose: Using berberine hydrochloride anhydrous swallowable granules produced by Kunming Bangyu Pharmaceutical Co., Ltd. as the test preparation, and berberine hydrochloride tablets certified by Shanghai Xinyi Tianping Pharmaceutical Co., Ltd. and produced by Zhejiang Qianjin Pharmaceutical Co., Ltd. as the control drug, the pharmacokinetic characteristics of absorption rate and degree of absorption in the human body under fasting and postprandial administration conditions in healthy adult subjects in China were compared, and the differences in intestinal excretion in healthy adult populations were compared. Secondary purpose: Observe and evaluate the safety of a single oral test preparation of berberine hydrochloride anhydrous swallowable granules for children and the control drug berberine hydrochloride tablets in healthy adult subjects in China under fasting and postprandial conditions.