Nanjing Hongjing Medical Technology Co., Ltd.

Primary purpose: To preliminarily explore the therapeutic effect of CZ130 capsules at different doses on liver inflammation in patients with non-alcoholic fatty liver disease (damp-heat accumulation type); Secondary purpose: (1) To preliminarily explore the effect of CZ130 capsules at different doses on the changes in liver fat content and improvement of liver fibrosis in patients with non-alcoholic fatty liver disease (damp-heat accumulation type); (2) To preliminarily explore the safety of CZ130 capsules at different doses in the treatment of patients with non-alcoholic fatty liver disease (damp-heat accumulation type).

1) To study the tolerance of healthy subjects to oral administration of Coptis chinensis Total Alkaloids Capsules for multiple times; 2) To explore the pharmacokinetic characteristics of Coptis chinensis Total Alkaloids Capsules for multiple times in healthy subjects, and to provide a reference for the selection of safe dose range and dosing regimen for Phase II clinical trials.

Main objectives: ? To study the tolerability of a single oral dose of Coptis chinensis total alkaloids capsules in healthy subjects ? To explore the pharmacokinetic characteristics of a single oral dose of Coptis chinensis total alkaloids capsules in healthy subjects