Ningbo Menovo TianKang Pharmaceutical Co., Ltd.

Primary objective: To compare the differences in absorption degree and speed between tranexamic acid tablets (specification: 0.5 g) provided by Ningbo Mennova Tiankang Pharmaceutical Co., Ltd. and certified tranexamic acid tablets (trade name: Tosamine®/Transamin®; specification: 0.5 g) of Daiichi Sankyo Co., Ltd. in healthy people under fasting and postprandial administration conditions. Secondary objective: To evaluate the safety of tranexamic acid tablets (specification: 0.5 g) provided by Ningbo Mennova Tiankang Pharmaceutical Co., Ltd. and certified tranexamic acid tablets (trade name: Tosamine®/Transamin®; specification: 0.5 g) of Daiichi Sankyo Co., Ltd. under fasting and postprandial administration conditions.

This trial aims to study the pharmacokinetic characteristics of ibrutinib capsules (140 mg) developed by Ningbo Minova Tiankang Pharmaceutical Co., Ltd. and produced by Jiangsu Huayang Pharmaceutical Co., Ltd. after single fasting and postprandial oral administration in healthy subjects; using ibrutinib capsules (Yike®, 140 mg) certified by Janssen-Cilag International NV as the reference preparation, the pharmacokinetic parameters Cmax, AUC0-t, and AUC0-∞ of the two preparations were compared, the human bioequivalence of the two preparations was evaluated, and the safety of the two preparations in healthy subjects was observed.

To investigate the pharmacokinetic characteristics of a single oral administration of tofacitinib citrate sustained-release tablets (test preparation, specification: 11 mg) provided by Ningbo Minova Tiankang Pharmaceutical Co., Ltd. under fasting and postprandial conditions in healthy subjects, and a single oral administration of tofacitinib citrate sustained-release tablets (reference preparation, trade name: Xeljanz®/Shangjie, specification: 11 mg) certified by Pfizer Inc. under the same conditions, to evaluate the bioequivalence and safety of the two preparations, and to provide a basis for the registration application of the test preparation.