Delving into the Latest Updates on Melacure Therapeutics AB with Synapse

Overview

Abstract14C‐Labelled N‐(2‐chloro‐3,4‐dimethoxybenzylideneamino)guanidinium acetate has been synthesized as a part of a four‐step procedure which involved decarboxylation of 2‐chloro‐3,4‐dimethoxybenzoic acid by Pb(OAc)4 to give 2‐chloro‐3,4‐dimethoxy‐1‐iodobenzene, followed by a selective lithiation at the iodine position and electrophilic substitution with N,N‐dimethylformamide [α‐14C] and final reaction with aminoguanidine bicarbonate. The specific activity was 59 mCi/mmol and the overall yield 49%. Copyright © 2002 John Wiley & Sons, Ltd.

01 Oct 2001·Expert Opinion on Therapeutic Patents

Ligands to the melanocortin receptors

Author: Skottner, Anna ; Seifert, Elisabeth ; Andersson, Per M. ; Lundstedt, Torbjorn ; Boman, Arne

A review.This article will give a brief overview of the pharmacol. of the melanocortin receptors (MCRs) as a background.The review will not handle the patents or patent applications dealing with cloning of the different subtypes of the receptor, since this has been recently reviewed [1].This review will focus on different ligands acting either as agonists or antagonists to the different subtypes of the receptor, i.e., MC₁R, MC₃R, MC₄R and MC₅R.Just recently a number of patent applications have reached the public domain, which describe small peptides or low mol. weight organic compounds binding and acting on the MCRs.

100 Deals associated with Melacure Therapeutics AB

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100 Translational Medicine associated with Melacure Therapeutics AB

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Pipeline

Pipeline Snapshot as of 28 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

HS-131 ( MC4R )	Opium Dependence More	Discontinued
ME-10393 (Melacure) ( melanocortin receptor )	Dermatitis More	Discontinued
PR-5 ( Xanthine oxidase )	Reperfusion Injury More	Discontinued