Tianjin Huajin Pharmaceutical Co. Ltd.

Primary study objective: To study the pharmacokinetics of the test preparation, Miasartan Potassium Tablets, and the reference preparation, Miasartan Potassium Tablets (trade name: Edabi®; specification: 40 mg; produced by Takeda Ireland Ltd.) in healthy subjects after a single oral administration in the fasting/postprandial state, and to evaluate the bioequivalence of the two preparations in the fasting/postprandial state. Secondary study objective: To evaluate the safety of the test preparation, Miasartan Potassium Tablets (specification: 40 mg) and the reference preparation, Edabi® (specification: 40 mg) in healthy subjects.

Main purpose: This study used irbesartan hydrochlorothiazide tablets (specification: each tablet contains 150 mg irbesartan and 12.5 mg hydrochlorothiazide) produced by Tianjin Huajin Pharmaceutical Co., Ltd. as the test preparation. According to the relevant provisions of the bioequivalence test, irbesartan hydrochlorothiazide tablets (trade name: Ambeno®, specification: 150 mg/12.5 mg: each tablet contains 150 mg irbesartan and 12.5 mg hydrochlorothiazide) produced by Sanofi Winthrop Industrie were used as the reference preparation. Human bioequivalence tests were conducted under fasting/fed conditions to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy subjects.

Main purpose: This study used cefixime capsules developed by Tianjin Huajin Pharmaceutical Co., Ltd. as the test preparation. According to the relevant regulations of bioequivalence tests, Cefspan certified by Choseido Pharmaceutical Co., Ltd. was used as the reference preparation. Human bioequivalence tests were conducted under fasting/postprandial conditions to evaluate the bioequivalence of the test preparation and the reference preparation in healthy subjects. Secondary purpose: To observe the safety of the test preparation and the reference preparation in healthy subjects.