An open label, two arm, randomized study to evaluate Dex-sparing benefits of the NEPA, an oral fixed combination of Netupitant and palonosetron, in Highly Emetogenic Chemotherapy (HEC) regimen

Start Date20 Jan 2021

Sponsor / Collaborator

The Prince Aly Khan Hospital

CTRI/2011/04/001688 / RecruitingNot ApplicableIIT

Prevalence and clinical impact of Human Papilloma Virus in patients with Head and Neck Squamous Cell Cancer treated prospectively at Prince Aly Khan Hospital - nil

Start Date25 Apr 2011

Sponsor / Collaborator

The Prince Aly Khan Hospital

CTRI/2011/05/001710 / RecruitingPhase 3IIT

Estimation of serum Iron, serum Ferritin and Total iron binding capacity (TIBC) levels in women with hair loss. - TIBC

Start Date14 Feb 2011

Sponsor / Collaborator

The Prince Aly Khan Hospital

100 Clinical Results associated with The Prince Aly Khan Hospital

0 Patents (Medical) associated with The Prince Aly Khan Hospital

155

Literatures (Medical) associated with The Prince Aly Khan Hospital

07 Nov 2023·Journal of Obesity

Defining and Diagnosing Obesity in India: A Call for Advocacy and Action

Review

Author: Kalra, Sanjay ; Verma, Madhur ; Shaikh, Shehla ; Das, Sambit ; Jacob, Jubbin ; Sahay, Rakesh ; Kapoor, Nitin

The prevalence of overweight and obesity has more than doubled since 1980, and it is predicted that around two-thirds of the global burden of the disease will be attributed to chronic non-communicable diseases. Developing countries are experiencing a more dramatic rise in the prevalence of obesity in recent years. As per National Family Health Survey-5 (NFHS-5), one in every four Indians is now having obesity. It has been reported that being overweight and obese is a significant problem among different socioeconomic spectrums of men and women in India, especially among the elderly, people residing in urban regions, and diverse socioeconomic strata. There is an urgent need to identify obesity as a chronic disease requiring immediate attention, mandating timely screening, timely treatment, and economical ways of achieving and managing weight loss across the country. In this review, the authors have discussed various aspects of overweight and obesity and critically appraised the current status of obesity in India, its public health implications, the significance of screening, the role of BMI and other parameters in diagnosing obesity, and the need for treatment and cost-effective prescriptions.

01 Jun 2023·Indian Journal of Surgical Oncology

High-Risk Peritoneal Mesothelioma: Does Metronomic Chemotherapy Have a Role?

Article

Author: Mehta, Sanket ; Maniar, Vashisth ; Anam, Jay ; Garach, Niharika ; Bhatt, Aditi ; Kammar, Praveen ; Gore, Adwaita

ObjectiveTo evaluate the feasibility, tolerance, and efficacy of OMCT (oral metronomic chemotherapy) after CRS + HIPEC for peritoneal mesothelioma in patients with poor prognostic factors: PCI > 20, incomplete CRS, poor performance status, or progression on systemic chemotherapy.MethodsA retrospective analysis of patients undergoing CRS + HIPEC for peritoneal mesothelioma and receiving OMCT for poor risk factors.ResultsSixteen patients underwent CRS + HIPEC between 2013 and 2017. The median PCI was 31.5. Complete cytoreduction (CC-0/1) was obtained in 8 patients (50%). All 16 received HIPEC except one patient with baseline renal dysfunction.Thirteen patients had PCI > 20 where only 5 had CC-0/1. Of 8 suboptimal cytoreduction (CC-2/3), 7 received OMCT (6 for progression on chemotherapy and one for mixed histology). Three patients had PCI < 20 and all had CC-0/1 clearance. Only one received OMCT for progression on adjuvant chemotherapy. Patients receiving OMCT for progression on adjuvant chemotherapy (ACT) were in poor PS.The median follow-up was 13.4 months. Five are alive with the disease (three are on OMCT). Six are alive without disease (2 are on OMCT). The mean OS was 24.3 months and the mean DFS was 18 months. Outcomes were similar between CC-0/1 and CC-2/3 groups, OMCT vs no OMCT groups.All patients receiving OMCT for progression on neoadjuvant chemotherapy had better survival (alive at 12, 20, 32, 36 months) compared to those receiving OMCT for progression on the ACT (p = 0.012).ConclusionOMCT is a good alternative in high-volume peritoneal mesothelioma with incomplete cytoreduction and progression on chemotherapy. OMCT may improve outcomes in these scenarios when started early.

01 Apr 2023·Indian Journal of Radiology and Imaging

ICRI White Paper: An Update on Role of Conventional Radiography in Imaging of Pediatric Gastrointestinal Tract

Review

Author: Varma, Ravi U. ; Shah, Rushit S. ; Modi, Tanvi ; Jain, Sanjay N.

AbstractPlain abdominal radiographs and gastrointestinal contrast studies remain the first line of investigation for the evaluation of several conditions due to their easy availability and ease of use in pediatric patients. A systematic approach to evaluating the plain radiograph for pediatric abdomen can lead the radiologist to a relevant differential diagnosis in most cases. In other cases, it leads the radiologist to the next line of investigation. The plain radiograph of the abdomen is requested for several conditions ranging from abdominal pain, vomiting, failure to pass meconium, abdominal distension, perforation, mass or for suspected obstruction. The radiation dose involved in abdominal radiography, although significant, the diagnostic information provided outweighs the risk. Dose reduction techniques should be employed to reduce the radiation dose to infants and children. Spectrum of atresias and stenosis from the esophagus up to the rectum, Hirschsprung disease, small left colon syndrome, and anorectal malformations can be identified with a detailed and systematic contrast study. They act as an adjunct in the diagnosis of conditions such as intussusception and hypertrophic pyloric stenosis. Inflammatory conditions such as acute appendicitis, necrotizing enterocolitis, and acute conditions such as pneumoperitoneum are also well appreciated on plain abdominal radiographs.

100 Deals associated with The Prince Aly Khan Hospital

100 Translational Medicine associated with The Prince Aly Khan Hospital

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