A Multicenter Randomized Clinical Trial to Assess the Advantages of Robotic Total Mesorectal Excision in Preserving External Sphincter in Patients with Middle and Low Rectal Cancer.

This is a multicenter, superior, randomized controlled trial designed to compare Robotic-assisted total mesorectal excision (RATME) and laparoscopic-assisted total mesorectal excision (LATME) for middle and low rectal cancer. The primary endpoint is the incidence of intersphincteric resection (ISR). The secondary outcomes are coloanal anastomosis (CAA), conversion to open, conversion to transanal TME (TaTME), incidence of abdominoperineal resection (APR), postoperative morbidity and mortality within 30 days after surgery, pathological outcomes, long-term survival outcomes, functional outcomes, and quality of life.

Start Date01 Nov 2025

Sponsor / Collaborator

The First Hospital of Jilin University

[+1]

NCT06882811

/ Not yet recruitingEarly Phase 1

Clinical Study on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Sepsis

The primary objective: To evaluate the efficacy of intravenous infusion of universal UC-MSCs and CD83+MSCs subpopulation injection in the treatment of sepsis by using the 28-day survival rate of the subjects as the primary efficacy criterion.The secondary objectives: 1. To systematically evaluate the safety of universal UC-MSCs and CD83+MSCs subpopulation in the treatment of sepsis; 2. To provide theoretical basis and clinical research data for establishing a safe, effective and feasible clinical treatment plan for sepsis using stem cells.

Start Date31 Mar 2025

Sponsor / Collaborator

Army Medical Center

NCT06728839

/ Not yet recruitingNot ApplicableIIT

Efficacy, Safety and Tolerability of Magnesium Sulfate With Low-volume Polyethylene Glycol for Bowel Preparation Before Colonoscopy: A Multicentre, Randomized, Controlled Trial

Magnesium salts such as magnesium citrate are often combined with polyethylene glycol to make the intestinal preparation before colonoscopy, which has shown high cleaning efficacy. Magnesium sulfate combined with polyethylene glycol is less used in the world. This multicenter, randomized, controlled trial is aimed at to evaluate the efficacy and safety of magnesium sulfate combined with low-volume polyethylene glycol for preoperative bowel preparation for colonoscopy.

Start Date09 Dec 2024

Sponsor / Collaborator

Changhai Hospital of Shanghai

[+11]

100 Clinical Results associated with Army Medical Center

0 Patents (Medical) associated with Army Medical Center

Literatures (Medical) associated with Army Medical Center

01 Mar 2025·Journal of Global Antimicrobial Resistance

Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020)

Article

Author: Cocuzza, Clementina Elvezia ; Ricci, Maria Luisa ; Mancini, Fabiola ; Fillo, Silvia ; Lanni, Alessio ; Iera, Jessica ; Musumeci, Rosario ; Lista, Florigio ; Girolamo, Antonietta ; Descours, Ghislaine ; Ciammaruconi, Andrea ; Jarraud, Sophie ; Scaturro, Maria ; Visca, Paolo ; Ginevra, Christophe

OBJECTIVESAlthough antimicrobial resistance has not yet emerged as an overarching problem for Legionella pneumophila (L. pneumophila) infection, the description of clinical and environmental strains resistant to fluoroquinolones and macrolides is a cause of concern. This study aimed to investigate the antimicrobial susceptibility of L. pneumophila human isolates in Italy.METHODSA total of 204 L. pneumophila clinical isolates were tested for sensitivity to 9 antibiotics using the broth microdilution assay (BMD). All isolates were typed by sequence-based typing, and Legionella pneumophila serogroup 1 (Lp1) isolates by monoclonal antibody subgrouping. Minimum inhibitory concentration (MIC) data were correlated with the possible source of infection and geographical distribution. The presence of the lpeAB efflux pump genes was also investigated. The genome sequences of a subpopulation of isolates showing reduced susceptibility to azithromycin were also analysed.RESULTSThe L. pneumophila isolates did not show significant resistance to the tested antibiotics, although a trend toward reduced sensitivity to azithromycin was observed in a subpopulation of 46 strains, most of which belonged to sequence type 1 (ST1), the second most widespread ST in Italy. An amplicon of the expected size overlapping the lpeAB genes was obtained only in the 46-subpopulation above mentioned. In 4 of the 46 isolates, sequencing analysis showed the occurrence of amino-acid substitutions already described in other strains. No further mutation was found.CONCLUSIONSThe presence of L. pneumophila strains with reduced susceptibility or resistance to azithromycin should be monitored to predict future trends and suggest to physicians a combined therapy with fluoroquinolones when a poor response to azithromycin is observed. © 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.

01 Feb 2025·Recent Patents on Anti-Cancer Drug Discovery

Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Tumor Immune Infiltration in Bladder Cancer

Article

Author: Dai, Nan ; Luo, Hao ; Zhong, Li ; Liu, Gao-Lei ; Lan, Wei-Hua ; Liang, Dan-Dan

Background:Bladder cancer exhibits substantial heterogeneity encompassing genetic expressions and histological features. This heterogeneity is predominantly attributed to alternative splicing (AS) and AS-regulated splicing factors (SFs), which, in turn, influence bladder cancer development, progression, and response to treatment.Objective:This study aimed to explore the immune landscape of aberrant AS in bladder cancer and establish the prognostic signatures for survival prediction.Methods:Bladder cancer-related RNA-Seq, transcriptome, and corresponding clinical information were downloaded from The Cancer Genome Atlas (TCGA). Gene set enrichment analysis (GSEA) was used to identify significantly enriched pathways of cancer-related AS events. The underlying interactions among differentially expressed genes (DEGs) and cancer-related AS events were assessed by a protein-protein interaction network. Univariate and multivariate Cox regression analyses were performed to identify crucial prognostic DEGs that co-occurred with cancer-related AS events (DEGAS) for overall survival. The area under the curve (AUC) of receiver operating characteristic (ROC) curves was used to assess the efficiency of the prognostic signatures. The CIBERSORT algorithm was used to explore the abundance of immune infiltrating cells.Results:A total of 3755 cancer-related AS events and 3110 DEGs in bladder cancer were identified. Among them, 379 DEGs co-occurred with cancer-related AS events (DEGAS), of which 102 DEGAS were associated with 14 dysregulated SFs. GSEA and KEGG analysis showed that cancer-related AS events were predominantly enriched in pathways related to immunity, tumorigenesis, and treatment difficulties of bladder cancer. Multivariate Cox regression analysis identified 8 DEGAS (CABP1, KCNN2, TNFRSF13B, PCDH7, SNRPA1, APOLD1, CX3CL1, and DENND5A) significantly associated with OS, and they were further integrated into the prediction model with good AUCs at 3-year, 5-year and 7-year ROC curves (all>0.7). Immune infiltration analysis revealed the significant enrichment of three immune cell types (B cells naïve, dendritic cells resting, and dendritic cell activated) in high-risk bladder cancer patients.Conclusion:This study not only unveiled comprehensive prognostic signatures of AS events in bladder cancer but also established a robust prognostic model based on survival-related DEGAS. These aberrant AS events, dysregulated SFs, and the identified 8 DEGAS may have significant clinical potential as therapeutic targets for bladder cancer.

25 Dec 2024·Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery

[Surgical treatment for slow transit constipation: total colectomy and subtotal colectomy].

Article

Author: Tong, W D ; Guo, M

Although the surgical treatment of slow transit constipation (STC) has been around for over a century, the choice of surgical method is still controversial. Specifically, the two most widely used operations in the world are total colectomy ileorectostomy (TC-IRA) and subtotal colectomy. Subtotal colectomy offers many methods for anastomosis, including ileocecal and cecorectal anastomoses and so on. Cecorectal anastomosis can be divided into two types: isoperistaltic anastomosis and antiperistaltic anastomosis. It is generally believed that total colectomy provides definitive effects but results in more severe postoperative diarrhea, while subtotal colectomy may reduce postoperative diarrhea but potentially increase the risk of constipation recurrence. Most studies of these surgical methods are retrospective small-sample studies with low-quality evidence. This is also one of the reasons for the lack of STC gold standard surgery in clinical practice. This paper discusses the selection of surgical methods for intractable slow transit constipation (STC) based on a review of literature published within the past 10 years, as well as our team's extensive 33-year experience in diagnosing and treating constipation surgically.

100 Deals associated with Army Medical Center

100 Translational Medicine associated with Army Medical Center

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Drug(Targets)	Indications	Global Highest Phase

Human Umbilical Cord Mesenchymal Stem Cells(Army Medical Center)	Sepsis More	Phase 1 Clinical
CD83-positve human umbilical cord mesenchymal stem cells(Daping Hospital) ( CD83 )	Sepsis More	Phase 1 Clinical

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