GlaxoSmithKline Export Ltd.

This study aimed to evaluate the pharmacokinetics, safety, and tolerability of lamotrigine dispersible tablets after repeated dosing in healthy Chinese subjects.

To verify the bioequivalence of two different dosage forms of 100 mg lamotrigine: dispersible tablets and standard tablets in healthy Chinese male subjects. To evaluate the safety and tolerability of 100 mg lamotrigine dispersible tablets in healthy Chinese male subjects.

To evaluate the efficacy and safety of lamotrigine 200 mg/day compared with placebo for the long-term (36 weeks) prevention of depressive, manic, hypomanic, or mixed episodes (measured as the time to intervention for a relapse or recurrence of a mood disorder) in participants with bipolar I disorder.