Aim of the Work To compare the clinical outcomes between patients will undergo slide tracheoplasty and those will undergo tracheal resection anastomosis for acquired tracheal stenosis.

Start Date01 Jun 2025

Sponsor / Collaborator

Mansoura University Hospital

PACTR202503887997647

/ SuspendedNot ApplicableIIT

Ultrasound-guided Mid-Transverse Process to Pleural Block versus Thoracic Paravertebral Block in Children undergoing Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Non-Inferiority Study.

Start Date08 Apr 2025

Sponsor / Collaborator

Mansoura University Hospital

NCT06788860

/ RecruitingNot ApplicableIIT

Efficacy of Ultrasound-Guided Tri-Directional Needle Knife Release for Trigger Finger

Efficacy of ultrasound-guided tri-directional needle knife release in treating patients with trigger finger. The study evaluates safety, effectiveness, and recovery outcomes of a minimally invasive procedure compared to conventional approaches.

Start Date20 Jan 2025

Sponsor / Collaborator

Mansoura University Hospital

100 Clinical Results associated with Mansoura University Hospital

0 Patents (Medical) associated with Mansoura University Hospital

647

Literatures (Medical) associated with Mansoura University Hospital

01 Dec 2025·Techniques in Coloproctology

Systematic review and meta-analysis of the efficacy and safety of stem cell treatment of anal fistulas

Review

Author: Garoufalia, Z ; Horesh, N ; Emile, S H ; Dourado, J ; Wexner, S D ; Rogers, P ; Wignakumar, A

AbstractBackgroundSince anal fistulas can be challenging to treat; numerous innovative treatments have been proposed, including stem cell therapy. This systematic review aimed to assess pooled rates of fistula healing and adverse events associated with stem cell treatment.MethodsIn this PRISMA-compliant systematic review we searched PubMed and Scopus for observational and randomized studies reporting outcomes of stem cell treatment for anal fistulas. The main outcome measures were successful healing and adverse effects of stem cell therapy.ResultsIn total, 43 studies incorporating 1160 patients (53.6% male) were included. Underlying fistula etiologies were Crohn’s disease (30 studies) and cryptoglandular disease (12 studies). The main origin of stem cells was from adipose tissue (34 studies) or bone marrow (6 studies). The median follow-up duration was 12 months. The combined overall pooled healing rate was 58.1% (95% confidence interval (CI) 51.5–64.7%). The pooled healing rate for Crohn’s fistulas was 60.4% (95% CI 54.7–66.2%) with adipose-derived stem cells and 63.6% (95% CI 49.4–77.7%) with bone-marrow-derived cells. The pooled healing rate for cryptoglandular fistulas was 53.8% (95% CI 35.5–72.2%) with adipose-derived stem cells. The pooled complication rate was 37.3% (95% CI 27.1–47.5%). Stem cells were associated with higher odds of anal fistula healing (odds ratio (OR): 1.81, p = 0.003) and similar odds of complications (OR: 1, p = 0.986) compared with controls.ConclusionsStem cell treatment of anal fistulas was associated with promising results. The healing rate in Crohn’s anal fistulas was higher than in cryptoglandular fistulas. Bone-marrow-derived stem cells were associated with marginally better outcomes than were adipose-derived cells. This finding suggests that the autoimmune inflammatory etiology of Crohn’s disease may respond better to autologous myoblasts than does the infectious etiology of cryptoglandular fistulas.

01 Dec 2025·Techniques in Coloproctology

Fecal microbiota transplantation for patients with ulcerative colitis: a systematic review and meta-analysis of randomized control trials

Review

Author: Garoufalia, Z ; Rogers, P ; Emile, S H ; Horesh, N ; Gefen, R ; Dourado, J ; Aeschbacher, P ; Wexner, S D ; Wignakumar, A

AbstractBackgroundFecal microbiota transplantation (FMT) has been shown to restore gut microbiome composition with an acceptable safety profile. FMT in inflammatory bowel disease, specifically ulcerative colitis (UC), has been investigated. We aimed to assess the efficacy of FMT in inducing UC remission.MethodsPubMed, Scopus, Google Scholar, and clinicaltrials.gov were searched for randomized control trials that assessed FMT in inducing UC remission. The primary outcome was combined clinical and endoscopic remission. Secondary outcomes were clinical remission, endoscopic remission, post-treatment overall adverse events, and colitis. Sensitivity analyses, meta-regression, bias assessment, and grading of certainty of evidence were performed.ResultsA total of 14 studies including 600 patients (55.8% male; median age 40.7 years) were assessed. FMT was used in 299 patients and associated with significantly higher odds of combined clinical and endoscopic remission (OR 2.25, 95% CI 1.54, 3.3; p < 0.0001), clinical remission (OR 2.02, 95% CI 1.4, 2.93; p = 0.0002), and endoscopic remission (OR 1.95, 95% CI 1.17, 3.28; p = 0.011). The odds of post-treatment overall adverse events (OR 1.24, 95% CI 0.79, 1.95; p = 0.34) and colitis (OR 0.85, 95% CI 0.52, 1.93; p = 0.512) were similar between groups. Compared with baseline, FMT was more effective when biologics (OR 2.71), steroids (OR 2.27), or methotrexate (OR 3.07) were used as pre-FMT treatment. Oral delivery of FMT (OR 3.15) and pooled donors (OR 3.32) led to higher odds of remission. On meta-regression, pooled donors and methotrexate pre-treatment were associated with an increased likelihood of remission.ConclusionsFMT is promising in inducing UC remission. Administration of medical treatments before FMT may help achieve higher remission rates. Current evidence shows that oral delivery of FMT and multidonor FMT may confer better results.

01 Dec 2025·Techniques in Coloproctology

Comparing answers of ChatGPT and Google Gemini to common questions on benign anal conditions

Article

Author: Emile, S H ; Freund, M R ; Horesh, N ; Wexner, S D ; Maron, C M ; Pellino, G

INTRODUCTIONChatbots have been increasingly used as a source of patient education. This study aimed to compare the answers of ChatGPT-4 and Google Gemini to common questions on benign anal conditions in terms of appropriateness, comprehensiveness, and language level.METHODSEach chatbot was asked a set of 30 questions on hemorrhoidal disease, anal fissures, and anal fistulas. The responses were assessed for appropriateness, comprehensiveness, and reference provision. The assessments were made by three subject experts who were unaware of the name of the chatbots. The language level of the chatbot answers was assessed using the Flesch-Kincaid Reading Ease score and grade level.RESULTSOverall, the answers provided by both models were appropriate and comprehensive. The answers of Google Gemini were more appropriate, comprehensive, and supported by references compared with the answers of ChatGPT. In addition, the agreement among the assessors on the appropriateness of Google Gemini answers was higher, attesting to a higher consistency. ChatGPT had a significantly higher Flesh-Kincaid grade level than Google Gemini (12.3 versus 10.6, p = 0.015), but a similar median Flesh-Kincaid Ease score.CONCLUSIONSThe answers of Google Gemini to questions on common benign anal conditions were more appropriate and comprehensive, and more often supported with references, than the answers of ChatGPT. The answers of both chatbots were at grade levels higher than the 6th grade level, which may be difficult for nonmedical individuals to comprehend.

100 Deals associated with Mansoura University Hospital

100 Translational Medicine associated with Mansoura University Hospital

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