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Last update 23 Jan 2025

Mansoura University Hospital

Egypt

Last update 23 Jan 2025

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Translational Medicine

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124

Clinical Trials associated with Mansoura University Hospital

NCT06657638

/ RecruitingNot ApplicableIIT

Diagnostic Yield of Cytological Examination of Malignant Pleural Effusion in Different Breast Cancer Pathologies

Malignant pleural effusion (MPE) is characterized by the presence of malignant cells. It can occur in 15% of patients with cancer and is a common manifestation in patients with metastatic disease.
Breast cancer (BC) is the second most common cause of MPE and MPE occurring in 2- 11% of patients with BC. Breast cancer is a heterogeneous disease of malignant tumors with diversified morphology, clinical course, biologic behavior and prognosis, and accurate tumor classification is critical for a patient's care.

Start Date19 Oct 2024

Sponsor / Collaborator

Mansoura University Hospital

NCT06629558

/ RecruitingNot ApplicableIIT

Efficacy and Safety of 0.5% w/v Nano- Silver Nitrate Versus Silver Nitrate Solution for Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema: Prospective Interventional Randomized Controlled Clinical Trial

Emphysema is a progressive phenotype of chronic Obstructive Pulmonary Disease (COPD), poses a significant global health burden characterized by irreversible lung parenchymal destruction and airspace enlargement.
In recent years, bronchoscopic lung volume reduction (BLVR) has considerable interest as a minimally invasive approach to reducing hyperinflation and improving lung function in patients with emphysema.
BLVR techniques aim to achieve lung volume reduction by occluding or ablating emphysematous lung tissue through endobronchial delivery of various agents. Many techniques are available for BLVR as coil, endo-bronchial valve, and biological as thrombin, autologous blood and chemicals as silver nitrate solution.

Start Date01 Oct 2024

Sponsor / Collaborator

Mansoura University Hospital

PACTR202408593043200

/ SuspendedNot ApplicableIIT

Effect of Dexmedetomidine (Precedex) Administration during Awake Craniotomy on Postoperative Inflammatory Markers and Stress Hormones in Patients with Chronic Subdural Hemorrhage: A Randomized controlled Study

Start Date10 Sep 2024

Sponsor / Collaborator

Mansoura University Hospital

100 Clinical Results associated with Mansoura University Hospital

0 Patents (Medical) associated with Mansoura University Hospital

608

Literatures (Medical) associated with Mansoura University Hospital

01 Feb 2025·Surgery

Association between tumor deposits and liver and lung metastases at diagnosis of colorectal cancer: A SEER-based analysis

Article

Author: Dourado, Justin ; Garoufalia, Zoe ; Wexner, Steven D. ; Emile, Sameh Hany ; Emile, Mona Hany ; Wexner, Steven D

BACKGROUNDTumor deposits are a unique histologic feature of colorectal cancer that is associated with adverse survival outcomes. The present study aimed to assess the association between tumor deposits and liver and lung metastases and to describe the characteristics of colorectal cancer associated with tumor deposits.METHODSThe Surveillance, Epidemiology, End Results (SEER) database was screened between 2010 and 2020 for patients with colorectal adenocarcinoma who underwent radical resection with data on tumor deposits. The primary outcome of the study was liver and lung metastases. The secondary outcome was the characteristics of patients with tumor deposits.RESULTSA total of 205,294 patients (52% male, mean age 66.5 years) were included in the study. Tumor deposits were detected in 20,059 (9.7%) patients. Patients with tumor deposits were younger and presented more often with larger tumors, T3/T4 tumors, N+ tumors, stage IV disease, left-sided and rectal cancers, signet-ring cell carcinomas, high-grade adenocarcinomas, and perineural invasion. Multivariable binary regression analyses showed that tumor deposits were associated with 72% higher odds of liver metastases (odds ratio 1.72, 95% confidence interval 1.62-1.82, P < .001) and 68% higher odds of lung metastases (1.68, 1.51-1.86, P < .001). The odds of liver metastases increased by 3% (odds ratio 1.03, 95% confidence interval 1.03-1.04, P < .001) and the odds of lung metastases increased by 2% (1.02, 1.01-1.03, P < .001) for each tumor deposit detected.CONCLUSIONSTumor deposit-positive colorectal cancers were larger, more often on the left side or in the rectum and presented with more advanced disease and unfavorable histology than tumor deposit-negative cancers. Tumor deposits were independently associated with 72% and 68% higher odds of liver and lung metastases, respectively.

01 Feb 2025·Annals of Surgery

30-day Morbidity and Mortality After Cholecystectomy for Benign Gallbladder Disease (AMBROSE)

Article

Author: Abdulaal, Gamaleldeen ; Siddiqui, Adeela ; Sakran, Nasser ; Omarov, Taryel ; Ashraf, Aabid ; Fung, Tak Kwan James ; Wadhawan, Himanshu ; Dawani, Surrendar ; Al-Shkirat, Ahmad Ghassan ; Marom, Gad Amram ; Chooklin, Serge ; Pandey, Anshuman ; Khuroo, Suhail ; Asghar, Syed Tanseer ; Boras, Zdenko ; Erdene, Sarnai ; Moretto, Gianluigi ; Verras, Georgios-Ioannis ; Gupta, Ajay ; Mulita, Francesk ; Clementi, Marco ; Aggarwal, Manisha ; Rajeev, Yashasvi ; Alkaseek, Akram ; Balasubaramaniam, Vignesh ; Petracchi, Enrique ; Millán, Carlos Alberto ; Degrate, Luca ; Jalaawiy, Humam ; Agarwalla, Ramesh ; Aceves-Ayala, Jose Miguel ; Elfeki, Hossam ; Singhal, Rishi ; Kanaan, Samir ; Calini, Giacomo ; Roth Cardoso, Victor ; Ouyahia, Amel ; Omar, Mohammed Ahmed ; Adamovich, Dmitry Mikhailovich ; Das, Jayanta Kumar ; Martinino, Alessandro ; Elhadi, Muhammed ; Ahmed, Kazi T. ; Said, Amira ; Mahawar, Kamal ; Pantoja Pachajoa, Diana Alejandra ; Maldonado, Ricardo David ; Kumar, Ashwani ; Wong, Geoffrey Yuet Mun ; Gkoutos, Georgios V. ; Elzayat, Ibrahim ; Grigorean, Valentin Titus ; Bhojwani, Rajesh ; Rais, Mounira ; Ashraf, Fariha ; Bravo Merodio, Laura ; Maqbool, Baila ; Singh, Cheena ; Mohammed Abu-Elfatth, Ahmed ; Liang, Hui

Objective:This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications.Background:Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level.Methods:A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes.Results:Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4263 (19.7%), and 6622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients, and severe bile duct injuries (Strasberg grades B–E) were reported in 48 (0.2%) patients. Patient age, American Society of Anesthesiologists physical status class, surgical setting, operative approach, and Nassar operative difficulty grade were identified as the 5 predictors demonstrating the highest relative importance in predicting postoperative complications.Conclusions:This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.

01 Feb 2025·Surgery

Risk factors for suicide in patients with colorectal cancer: A Surveillance, Epidemiology, and End Results database analysis

Article

Author: Emile, Sameh Hany ; Wignakumar, Anjelli ; Horesh, Nir ; Wexner, Steven D ; Gefen, Rachel ; Dourado, Justin ; Garoufalia, Zoe ; DeTrolio, Victoria ; Wexner, Steven D.

BACKGROUNDSpecific risk factors for suicide in patients with colorectal cancer have not been well established. Therefore, we aimed to assess factors associated with increased risk of suicide among patients with colorectal cancer.METHODSThis was a retrospective cohort analysis of consecutive patients with colorectal cancer. Patients who survived were compared with patients for whom suicide was registered as their cause of death. Data were extracted from the National Cancer Institute's Surveillance, Epidemiology, and End Results Research Database 2000-2020. Primary outcome was risk factors for suicide.RESULTSIn total, 309,561 patients were included in the analysis; 160,095 (51.7%) were male. Suicide was the cause of death in 1,052 (0.34%). The suicide rate among patients with colorectal cancer decreased over time from 1% between 2000 and 2010 to 0.05% between 2011 and 2020 (P < .001). Male sex (odds ratio, 6.44; P < .001), non-Hispanic ethnicity (odds ratio, 2.84; P = .014), household income between $50,000 and $74,999 (odds ratio, 1.79; P = .008) or <$50,000 (odds ratio, 1.84; P = .030), and metastatic disease (odds ratio, 2.89; P = .001) were independent risk factors for suicide. Colorectal cancer diagnosis in the second half of the study (2011-2020) was associated with lower risk of suicide compared with the first half (odds ratio, 0.338; P < .001).CONCLUSIONAmong patients with colorectal cancer, male patients of non-Hispanic ethnicity and income <$75,000 USD who presented with metastatic disease were at increased risk of suicide. This trend decreased in the last decade, especially compared with the suicide rate among all patients with cancer. On the basis of these findings, we recommend targeted screening of this group of patients with colorectal cancer for suicidality as part of routine oncologic care.

100 Deals associated with Mansoura University Hospital

100 Translational Medicine associated with Mansoura University Hospital

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