Zhejiang East Asia Pharmaceutical Co., Ltd.

This research work reports the cilostazol (form A) dissolution in (ethylene glycol / ethanol + water) mixturesThe co-solvency phenomenon only occurs in mixture of ethanol + water, the maximum solubility in mole fraction is 3.034 x 10^-3 at the composition of 0.85.It was found that the solvation performance of cilostazol in two mixtures mainly depend on the ability of forming hydrogen bond (H-bond) of the solutions and van der Waals interaction.According to the preferential solvation results, it is conjecturable that cilostazol mols. are preferentially solvated by water in water-rich regions.With the increase of alc. concentration, the destruction of water mol. ordered structure by alc. through hydrogen bond, and solute mols. are preferentially solvated by ethanol and EG.Nonetheless, when 0.86 < x1 < 1 in mixture of ethanol + water, solute mols. are preferentially solvated by water again.The calculation of radial distribution function (RDF) between the atoms of H and O for ethanol and the atoms of N and H for solute is to achieve the interaction of the solute and solvents.The correlation fitting was performed for the solubility data through Jouyban Acree model and its derivative models, and the statistical anal. showed that the Apelblat-Jouyban Acree model is more suitable to present the solubility correlation.Meanwhile, the values of apparent molar standard dissolution enthalpy (ΔHosol) and apparent molar standard dissolution entropy (ΔSosol) are pos. in each solvents, which reveals that the dissolution process of cilostazol form A is endothermic and entropy favorable within the given temperature range.

In this study, an ambient mass spectrometry (AMS) based method was developed for rapid detection of organophosphorus pesticides in strawberry.This method combines an elec. arc and a microsyringe tip to realize tip-assisted ambient elec. arc ionization (TAAEAI).A high-voltage elec. arc can be applied to the microsyringe tip to generate an elec. field, which results in corona discharge at the microsyringe tip.The juiced strawberry sample loaded on the tip could be directly ionized with TAAEAI and then analyzed by a mass spectrometer.TAAEAI-MS was successfully applied to analyze 6 organophosphorus pesticides in three strawberry samples.Malathion and profenofos were detected from the investigated strawberry samples.This method could quant. the contents of organophosphorus pesticides in strawberry with high reproducibility, high precision, and high sensitivity.Sample matrixes did not interfere with the pesticide anal.The recoveries of organophosphorus pesticides spiked in strawberry samples varied between 82.6% and 116% with relative standard deviations (RSDs) less than 9.2%.The limits of detection (LODs) varied between 0.0124μg/g and 0.0245μg/g, while the limits of quantification (LOQs) varied between 0.0413μg/g and 0.0817μg/g.The coefficients of determination (R2) of the method were determined to be > 0.995.The method established here may have potential application in the detection of organophosphorus pesticides in vegetables and fruits.