Les Hôpitaux Universitaires de Genève

Châtillon, France, May 30, 2024 DBV Technologies to Participate in Upcoming EAACI 2024 Congress DBV Technologies (Euronext: DBV – ISIN: FR0010417345 – Nasdaq Stock Market: DBVT), a clinical-stage biopharmaceutical company focused on treatment options for food allergies and other immunologic conditions with significant unmet medical need, today announced its upcoming participation in the European Academy of Allergy and Clinical Immunology (EAACI) Congress May 31 – June 3 in Valencia, Spain. A flash talk presentation by Nicolette Arends, M.D., Erasmus University Rotterdam will describe data collected on accidental peanut consumption from DBV’s EPITOPE Phase 3 study and its ongoing open-label extension study in peanut-allergic toddlers aged 1 through 3 years. DBV will also host a symposium and exhibit booth in the EAACI exhibit hall. “We are deeply committed to establishing long-term safety and clinical data of Viaskin Peanut in the pediatric population, which includes examining reactions that occur during accidental consumption,” said Daniel Tassé, Chief Executive Officer of DBV Technologies. “While avoidance is the first line of defense, the reality is an accidental exposure is likely, necessitating approved treatment options that can help provide protection.” “We track accidental peanut consumption in our clinical studies to better understand how epicutaneous immunotherapy with Viaskin Peanut may help reduce the risk of an allergic reaction over time,” said Pharis Mohideen, M.D. Chief Medical Officer at DBV Technologies. “Analyzing accidental peanut consumption exposure better characterizes the real-world clinical benefit that Viaskin Peanut may provide if approved.” DBV’s symposium, “Epicutaneous Route: An Innovative Potential Approach to Food Immunotherapy”, will be moderated by Stefania Arasi, M.D., Ph.D., MSc., Pediatric Allergist and Researcher at Paediatric Allergy Unit, Bambino Gesù Children Research Hospital, Rome, Italy and current EAACI Pediatric Section Chair and Philippe Eigenmann, M.D., Pediatric Allergist and Head of Pediatric Allergy Unit at the Geneva University Hospital, Geneva, Switzerland. It will include lectures by Luciana Tanno, M.D., Ph.D. Allergist, Division of Allergy, University Hospital of Montpellier, Montpellier, France on potential clinical applications of the epicutaneous route, and Pablo Rodríguez del Río, M.D., Ph.D., Allergist Hospital Infantil Universitario Niño Jesús, Department of Allergy, Madrid, Spain, on most recent results and perspectives of the epicutaneous route in peanut allergy, respectively. DBV will host a booth (F10) in the exhibit hall where attendees can learn more about epicutaneous immunotherapy with Viaskin, including our ongoing clinical trials in peanut-allergic children. Flash Talk Presentation Details “Reactions Due to Accidental Peanut Consumption During Epicutaneous Immunotherapy for Peanut Allergy in Toddlers” presented by Nicolette Arends, M.D. Researcher, Pediatrics Erasmus University Medical Center, Rotterdam, Netherlands Session title: Flash Talks on PediatricsSession number: FT 15Session date: Sunday, June 2, 2024Session time: 8:30 a.m. – 10:30 a.m. CET A voice-recording of the onsite flash talk presentation will be made available on the congress platform. A copy of the poster will be made available after the presentation on the Scientific Publications & Presentations page on the Our Science section of the Company’s website www.dbv-technologies.com. Symposium “Epicutaneous route: An innovative potential approach to food immunotherapy” will be moderated by Stefania Arasi and Philippe Eigenmann Date and location: Saturday, June 1, 12:00 – 1:00 p.m. CEST, Malaga RoomLectures: Introduction- Dr. Stefania ArasiThe epicutaneous route: from the concept to potential clinical applications- Dr. Luciana Tanno The epicutaneous immunotherapy for peanut allergy: most recent results and perspectives- Dr. Pablo Rodríguez del RíoConclusion- Dr. Philippe Eigenmann About DBV TechnologiesDBV Technologies is a clinical-stage biopharmaceutical company developing treatment options for food allergies and other immunologic conditions with significant unmet medical need. DBV is currently focused on investigating the use of its proprietary technology platform, Viaskin™, to address food allergies, which are caused by a hypersensitive immune reaction and characterized by a range of symptoms varying in severity from mild to life-threatening anaphylaxis. Millions of people live with food allergies, including young children. Through epicutaneous immunotherapy (EPIT™), the Viaskin platform is designed to introduce microgram amounts of a biologically active compound to the immune system through intact skin. EPIT is a new class of non-invasive treatment that seeks to modify an individual’s underlying allergy by re-educating the immune system to become desensitized to allergen by leveraging the skin’s immune tolerizing properties. DBV is committed to transforming the care of food allergic people. The Company’s food allergy programs include ongoing clinical trials of Viaskin Peanut in peanut allergic toddlers (1 through 3 years of age) and children (4 through 7 years of age). DBV Technologies is headquartered in Châtillon, France, with North American operations in Warren, NJ. The Company’s ordinary shares are traded on segment B of Euronext Paris (Ticker: DBV, ISIN code: FR0010417345) and the Company’s ADSs (each representing one-half of one ordinary share) are traded on the Nasdaq Stock Market (Ticker: DBVT). For more information, please visit www.dbv-technologies.com and engage with us on X (formerly Twitter) and LinkedIn. Forward Looking StatementsThis press release may contain forward-looking statements and estimates, including, but not limited to, statements regarding the therapeutic potential of Viaskin™ Peanut and EPIT™ and DBV’s planned regulatory and clinical efforts including timing and results of communications with regulatory agencies, and the ability of any of DBV’s product candidates, if approved, to improve the lives of patients with food allergies. These forward-looking statements and estimates are not promises or guarantees and involve substantial risks and uncertainties. At this stage, DBV’s product candidates have not been authorized for sale in any country. Among the factors that could cause actual results to differ materially from those described or projected herein include uncertainties associated generally with research and development, clinical trials and related regulatory reviews and approvals, and DBV’s ability to successfully execute on its budget discipline measures. A further list and description of risks and uncertainties that could cause actual results to differ materially from those set forth in the forward-looking statements in this press release can be found in DBV’s regulatory filings with the French Autorité des Marchés Financiers (“AMF”), DBV’s filings and reports with the U.S. Securities and Exchange Commission (“SEC”), including in DBV’s Annual Report on Form 10-K for the year ended December 31, 2023, filed with the SEC on March 7, 2024, and future filings and reports made with the AMF and SEC by DBV. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements and estimates, which speak only as of the date hereof. Other than as required by applicable law, DBV Technologies undertakes no obligation to update or revise the information contained in this Press Release. Viaskin and EPIT are trademarks of DBV Technologies. Investor Contact Katie MatthewsDBV Technologieskatie.matthews@dbv-technologies.com Media ContactAngela MarcucciDBV Technologiesangela.marucci@dbv-technologies.com Attachment PDF Version

AC Immune Reports Full Year 2023 Financial Results and Provides a Corporate Update ACI-24.060 ABATE Phase 2 trial to report Abeta-PET imaging results in Q2 and H2ACI-7104.056 VacSYn Phase 2 trial in Parkinson’s disease on track for interim data in H2ACI-24.060 for Alzheimer’s disease (AD) received FDA Fast Track designationACI-35.030 ReTain Phase 2b program in preclinical (pre-symptomatic) AD patients, initiated by collaboration partnerCash of CHF 103 million at year end, plus the CHF 15 million milestone payment received on February 1, 2024 and the next CHF 25 million ACI-35.030-related milestone, provides funding into 2026 Lausanne, Switzerland, March 14, 2024 – AC Immune SA (NASDAQ: ACIU), a clinical-stage biopharmaceutical company pioneering the development of precision medicine approaches for the diagnosis, treatment, and prevention of neurodegenerative diseases, today reported results for the year ended December 31, 2023, and provided a corporate update. Dr. Andrea Pfeifer, CEO of AC Immune SA, commented: “We made significant progress in 2023 advancing our three innovative active immunotherapy programs in Phase 2 clinical trials in Alzheimer’s and Parkinson’s diseases. This sets the stage for a number of important milestones in 2024, which have the potential to further enhance our understanding of how best to prevent neurodegeneration and to generate significant value for AC Immune. In the second quarter and second half of 2024, we will be reporting Phase 2 ACI-24.060 data on amyloid plaque reduction after 6- and 12-months treatment, respectively. Amyloid plaque is a clinically validated biomarker of efficacy, making these data announcements potentially de-risking and providing an opportunity to accelerate ACI-24.060 into a registrational program. “We are also delighted that ACI-35.030 (JNJ-64042056), our anti-phospho-Tau active immunotherapy, has now entered the Phase 2b trial, conducted by our partner in pre-symptomatic AD patients. In addition, our ACI-7104.056 anti-alpha-synuclein active immunotherapy is advancing through Phase 2 testing for Parkinson’s disease (PD) with initial safety and immunogenicity data expected in the second half of 2024. “AC Immune’s primary focus remains on these three active immunotherapy programs, each of which has the potential to transform how neurodegenerative diseases are treated and ultimately, to enable precision prevention of these diseases. Thanks to our strengthened leadership team and reinforced balance sheet, we are well-positioned to deliver de-risking clinical milestones, working towards our mission to shift the paradigm from disease treatment to disease prevention.” 2023 and Subsequent Highlights Active Immunotherapy Programs ACI-24.060 anti-Abeta active immunotherapy Received Fast Track Designation from the U.S. Food and Drug Administration for the treatment of ADThe enrolment in the ABATE Phase 2 AD trial continues with cohort 3 now being expanded. Following data safety monitoring board (DSMB) review, no safety concerns have been raised to date, consistent with the previously observed safety profile.Initial interim ABATE safety and immunogenicity data from the first, low dose AD cohort were promising, with clear evidence of anti-Abeta antibody responses against toxic Abeta species observed in the blinded data.The first participant with Down syndrome (DS) was dosed in the Phase 2 ABATE trial.Six-month Abeta positron emission tomography (PET) imaging results are expected in Q2 2024, and 12-month Abeta-PET data are expected in H2 2024. ACI-35.030 (JNJ-64042056) anti-phospho-Tau (anti-pTau) active immunotherapy Phase 2b ReTain clinical trial in participants with preclinical AD preparations are ongoing to initiate the study by H1 2024 by Janssen Pharmaceuticals, Inc., a Johnson & Johnson company (Janssen).ReTain will evaluate the effect of ACI-35.030 on cognition and Tau pathology in approximately 500 participants with preclinical AD. These will be randomized in a 1:1 ratio to a single dose level of ACI-35.030 or placebo, administered as intramuscular injections for a maximum of 4 years.Under the terms of the licensing agreement, AC Immune received a milestone payment of CHF 15 million on February 1, 2024 and expects to receive another milestone payment of CHF 25 million related to achieving an undisclosed enrolment target in 2025. ACI-7104.056 anti-a-syn active immunotherapy Completed enrolment of cohort 1 in the VacSYn Phase 2 trial in Parkinson’s disease (PD), with 16 patients randomized. Enrolment and randomization of cohort 2 is ongoing as planned.No safety concerns have been reported to date with no reports of moderate or severe adverse events. Safety and immunogenicity updates from the trial are expected in H2 2024. Diagnostic Programs A peer-reviewed paper published in Nature Communications (Smith et al., Nat. Comm., 2023) showed that AC Immune’s wholly-owned a-syn-PET tracer ACI-12589 can detect a-syn pathology in multiple system atrophy (MSA) and differentiate MSA from other a-synucleinopathies.The TDP-43-PET tracer program has progressed as planned and a clinical candidate has been selected. Further IND-enabling studies will be completed over the coming months to permit the initiation of a Phase 1 clinical trial in H2 2024.In the pivotal Phase 3 ADvance trial evaluating the Morphomer® derived Tau-PET tracer, PI-2620 in AD, the first participant was imaged and the study is progressing well. PI-2620 was discovered and developed using the Morphomer® platform as part of a research collaboration between AC Immune and Life Molecular Imaging. Corporate Updates Completed USD 50 million equity financing in December 2023, extending cash runway into Q1 2026. (This assumes the second ACI-35-related milestone payment of CHF 25 million is received in 2025)New grants that collectively provide more than USD 500,000 in additional non-dilutive capital to support the advancement of diagnostic programs targeting TDP-43 (TAR DNA-binding protein 43) were awarded to AC Immune by The Michael J. Fox Foundation for Parkinson’s Research (MJFF) and the Target ALS Foundation.Strengthened leadership team with appointments of Dr. Nuno Mendonça as Chief Medical Officer, Dr. Madiha Derouazi as Chief Scientific Officer, and Mr. Christopher Roberts as Chief Financial Officer. Thought Leadership and Collaborations Initiated a research collaboration with Prof. Michael Heneka, director of the Luxembourg Centre for Systems Biomedicine, University of Luxembourg, to evaluate the therapeutic potential of AC Immune’s SupraAntigen®- and Morphomer®-derived inhibitors of the NLRP3-ASC inflammasome pathway in preclinical disease models.Hosted webinar on PET imaging in AD featuring key opinion leader (KOL) Victor Villemagne, M.D. (University of Pittsburg). To view a replay of the event, click HERE.Hosted KOL webinar on early diagnosis and prevention of AD featuring presentations by Kaj Blennow, MD, PhD, of University of Gothenburg and Sahlgrenska University Hospital, and Giovanni Frisoni, MD, of University of Geneva and the Memory Clinic at Geneva University Hospital. To view a replay of the webinar, click HERE. Anticipated 2024 Milestones ACI-24.060anti-Abeta active immunotherapy 6-month and 12-month Abeta-PET data in AD expected in Q2 2024 and H2 2024, respectivelyInitial safety and immunogenicity data in DS cohort expected in H2 2024 ACI-7104.056anti-a-syn active immunotherapy Interim safety and immunogenicity update from the Phase 2 VacSYn study in Parkinson’s disease expected in H2 2024 ACI-35.030anti-pTau active immunotherapy First-patient in ReTain Phase 2b clinical trial expected in H1 2024 Anti-TDP-43 antibody Completion of regulatory tox studies expected in H1 2024 TDP-43-PET tracer Phase 1 initiation expected in H2 2024 ACI-15916 a-syn-PET tracer IND-enabling studies in PD expected to be completed in H2 2024 Analysis of Financial Statements for the Year Ended December 31, 2023 Cash Position: The Company had a total cash balance of CHF 103.1 million as of December 31, 2023, compared to a total cash balance of CHF 122.6 million as of December 31, 2022. On February 1, 2024, the Company received the milestone payment of CHF 14.8 million from Janssen for the commencement of ReTain, the ACI-35.030 Phase 2b clinical study. The Company’s cash balance provides sufficient capital resources to progress into at least Q1 2026, assuming potential milestone payment of CHF 24.6 million related to achieving an undisclosed enrolment target for our ACI-35.030 and no other milestones.Contract Revenues: The Company recorded CHF 14.8 million in contract revenues for the year end December 31, 2023 compared with CHF 3.9 million in contract revenues in the prior year. For the year ended December 31, 2023, our contract revenues of CHF 14.8 million were related to the commencement of the first Phase 2b clinical study of ACI-35.030 per our agreement with Janssen.R&D Expenditures: R&D expenses decreased by CHF 5.7 million for the year ended December 31, 2023 to CHF 54.6 million, predominantly due to: Discovery and preclinical expenses (- CHF 5.8 million): The Company decreased expenditures across a variety of its discovery and preclinical programs.Clinical expenses (- CHF 2.0 million): The Company had a net decrease in clinical expenditures largely due the completion of the Phase 1b/2a and the advancement into Phase 2b for our ACI-35.030 active immunotherapy. We increased expenditures for the continued clinical development of our Phase 1b/2 ABATE study for ACI-24.060.Salary- and benefit-related costs (+ CHF 2.2 million): While the staffing position remained stable in 2023, personnel expenses increased due to the annualization of 2022 hires. G&A Expenditures: G&A expenses decreased by CHF 0.5 million for the year ended December 31, 2023 to CHF 15.3 million. This decrease is related to a decrease in operating expenses across various cost centers. This is partially offset by an increase in salaries and related costs.Other Operating Income: The Company recorded CHF 1.4 million in grant income for R&D activities performed under our grants for the year ended December 31, 2023.IFRS Loss for the Period: The Company reported a net loss after taxes of CHF 54.2 million for the year ended December 31, 2023, compared with a net loss of CHF 70.8 million for the prior period. About AC Immune SA AC Immune SA is a clinical-stage biopharmaceutical company and a global leader in precision prevention for neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and NeuroOrphan indications driven by misfolded proteins. The Company’s two clinically validated technology platforms, SupraAntigen® and Morphomer®, fuel its broad and diversified pipeline of first- and best-in-class assets, which currently features sixteen therapeutic and diagnostic programs, five of which are currently in Phase 2 clinical trials and one of which is in Phase 3. AC Immune has a strong track record of securing strategic partnerships with leading global pharmaceutical companies, resulting in substantial non-dilutive funding in potential milestone payments plus royalties. SupraAntigen® is a registered trademark of AC Immune SA in the following territories: AU, EU, CH, GB, JP, RU, SG and USA. Morphomer® is a registered trademark of AC Immune SA in CN, CH, GB, JP, KR, NO and RU. The information on our website and any other websites referenced herein is expressly not incorporated by reference into, and does not constitute a part of, this press release. For further information, please contact: SVP, Investor Relations & Corporate CommunicationsGary Waanders, Ph.D., MBAAC ImmunePhone: +41 21 345 91 91Email: gary.waanders@acimmune.comU.S. InvestorsCorey Davis, Ph.D.LifeSci AdvisorsPhone: +1 212 915 2577 Email: cdavis@lifesciadvisors.comInternational MediaChris MaggosCohesion BureauPhone: +41 79 367 6254Email: chris.maggos@cohesionbureau.com Forward looking statementsThis press release contains statements that constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include statements that address future operating, financial or business performance or AC Immune’s strategies or expectations. In some cases, you can identify these statements by forward-looking words such as “may,” “might,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “projects,” “potential,” “outlook” or “continue,” and other comparable terminology. Forward-looking statements are based on management’s current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include those described under the captions “Item 3. Key Information – Risk Factors” and “Item 5. Operating and Financial Review and Prospects” in AC Immune’s Annual Report on Form 20-F and other filings with the Securities and Exchange Commission. Forward-looking statements speak only as of the date they are made, and AC Immune does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. All forward-looking statements are qualified in their entirety by this cautionary statement. Consolidated Balance Sheets(In CHF thousands) As of December 31, 2023 2022Assets Non-current assets Property, plant and equipment 3,376 4,259Right-of-use assets 3,508 2,808Intangible asset 50,416 50,416Long-term financial assets 361 361Total non-current assets 57,661 57,844 Current assets Prepaid expenses 6,437 4,708Accrued income 246 408Other current receivables 622 392Accounts receivable 14,800 —Short-term financial assets 24,554 91,000Cash and cash equivalents 78,494 31,586Total current assets 125,153 128,094Total assets 182,814 185,938 Shareholders' equity and liabilities Shareholders’ equity Share capital 2,089 1,797Share premium 474,907 431,323Treasury shares (105) (124)Currency translation differences (51) 10Accumulated losses (316,197) (264,015)Total shareholders’ equity 160,643 168,991 Non-current liabilities Long-term lease liabilities 2,825 2,253Net employee defined benefit liabilities 5,770 3,213Total non-current liabilities 8,595 5,466 Current liabilities Trade and other payables 1,679 929Accrued expenses 11,087 9,417Deferred income 138 587Short-term lease liabilities 672 548Total current liabilities 13,576 11,481Total liabilities 22,171 16,947Total shareholders’ equity and liabilities 182,814 185,938 Consolidated Statements of Income/(Loss)(In CHF thousands, except for per-share data) For the Year Ended December 31, 2023 2022 2021Revenue Contract revenue 14,801 3,935 —Total revenue 14,801 3,935 — Operating expenses Research & development expenses (54,606) (60,336) (62,282)General & administrative expenses (15,305) (15,789) (17,910)Other operating income/(expense), net 1,486 1,343 1,182Total operating expenses (68,425) (74,782) (79,010)Operating loss (53,624) (70,847) (79,010) Financial income 1,044 69 6,485Financial expense (176) (355) (581)Exchange differences (1,467) 393 113Finance result, net (599) 107 6,017 Loss before tax (54,223) (70,740) (72,993)Income tax expense (10) (13) (3)Loss for the period (54,233) (70,753) (72,996) Loss per share: Basic and diluted loss for the period attributable to equity holders (0.64) (0.85) (0.97) Consolidated Statements of Comprehensive Income/(Loss)(In CHF thousands) For the Year Ended December 31, 2023 2022 2021Loss for the period (54,233) (70,753) (72,996)Items that may be reclassified to income or loss in subsequent periods (net of tax): Currency translation differences (61) 10 —Items that will not to be reclassified to income or loss in subsequent periods (net of tax): Remeasurement gains/(losses) on defined-benefit plans (net of tax) (1,669) 4,426 956Other comprehensive income/(loss) (1,730) 4,436 956Total comprehensive loss, net of tax (55,963) (66,317) (72,040) Attachment 20240314_ACIU_Q4_Earnings_FINAL-pg

Giovanni Frisoni, MD joins SAB comprised of prominent global Alzheimer’s, neuromodulation and neuroscience experts including Jeffrey Cummings MD, ScD(HC); Ana Pereira MD; Simone Rossi MD, PhD; Casey Lynch, MS SAB will help guide the company’s Phase 3 clinical development plans based on unprecedented Phase 2 data in Alzheimer’s showing >80% disease slowing on cognitive & functional endpoints CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Sinaptica Therapeutics, Inc., a clinical-stage company leading the development of a new class of personalized neuromodulation therapeutics to treat Alzheimer’s (AD) and other neurodegenerative diseases, announces the appointment of Giovanni Frisoni, MD to complete the company’s Scientific Advisory Board. Comprised of internationally renowned experts in a range of fields including Alzheimer’s, neuromodulation, and neurology, the SAB provides strategic oversight and guidance for the global development of Sinaptica’s investigational precision network neuromodulation therapy for Alzheimer’s Disease as the company prepares for a pivotal Phase 3 clinical trial this year. “With a breakthrough of this magnitude, we knew we needed to surround ourselves with the best advisors from across the scientific continuum—from AD pathology and biomarkers to neuro-electrophysiology and clinical trial design—to help guide Sinaptica as we develop this groundbreaking neuromodulation therapy,” said Sinaptica CEO Ken Mariash. “We’re honored to have Prof. Frisoni, an international leader in the field of clinical and translational Alzheimer’s research, join our esteemed board of scientific and clinical experts.” “I’m pleased to join Sinaptica’s SAB at a time when Precision Medicine, AI/ML, and the emerging field of ‘perturbation-based biomarkers’ are for the first time making it possible to decode brain signals at the individual’s connectome level, allowing personalized modulation of entire functional networks—not just stimulating simple anatomical targets,” said Professor Frisoni. Sinaptica is building on unprecedented positive Phase 2 data in Alzheimer’s published by the company’s scientific co-founders, showing greater than 80% disease slowing on all four gold-standard cognitive and functional clinical endpoints, in the peer-reviewed Oxford University Press journal, Brain. Sinaptica’s technology has been granted FDA Breakthrough Device Designation. Giovanni Frisoni, MD, is a clinical neurologist, Full Professor of Clinical Neuroscience at the University of Geneva, Switzerland, and Director of the Memory Clinic at Geneva University Hospital where he is leading a team of 40 clinicians and scientists. Formerly the Director at the National Alzheimer’s Centre in Bresca, Italy, Prof. Frisoni is author of about 700 scientific papers listed in PubMed, imaging editor for Neurobiology of Aging, and founding editorial board member of The Lancet Neurology. He has led national and international projects funded by the European Commission, the Alzheimer’s Association, Italian and Swiss Ministries of Health, and industry. He is currently a leading figure worldwide in microbiota studies in dementia, has taken active part in the IWG initiative for the definition of global diagnostic criteria for Alzheimer’s disease, and is leading a European working group of experts tasked with developing protocols and procedures for the memory clinics of the future (brain health services for dementia prevention). Other members of Sinaptica’s Scientific Advisory Board include: Jeffrey L. Cummings, MD, ScD(HC), Joy Chambers-Grundy Professor of Brain Science at UNLV School of Integrated Health Sciences and Director of the Chambers-Grundy Center for Transformative Neuroscience. Prior to UNLV, Dr. Cummings served as founding director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, and as director of the Mary S. Easton Center for Alzheimer’s Disease Research, and director of the Deane F. Johnson Center for Neurotherapeutics, both at UCLA. A world-renowned Alzheimer’s researcher and leader of clinical trials, Dr. Cummings has been recognized with many awards for his scientific and leadership contributions. He has published over 900 articles and 44 books devoted to neuroscience, Alzheimer’s disease, and clinical trials. Casey Lynch, MS, CEO of Lighthouse Pharmaceuticals and Managing Partner of Sonoma Bioventures, an investment and advisory firm, with more than 25 years of experience as an entrepreneur, executive and director with a focus on development of treatments for neurological disorders. Lynch is a member of the board of directors of Longboard Pharmaceuticals (LBPH), a public company developing the next wave of neuropharmaceuticals, and a member of the review board of the Alzheimer’s Drug Development Foundation. She previously co-founded and served as President, CEO and member of the board of directors of Cortexyme, Inc., serving as Chairman from November 2018 through January 2022. She was a member of the board of directors of the California Life Science Association, a trade association representing California’s life science industry, from 2019 to 2021. Prior to co-founding Cortexyme, Ms. Lynch co-founded various companies and organizations in the biotechnology industry, including Aspira Biosystems and NeuroInsights. Ana Pereira, MD, neurologist at the Barbara and Maurice Deane Center for Wellness and Cognitive Health at The Mount Sinai Hospital, New York. Dr. Pereira completed her neurology residency at Harvard University, with sub-specialty trainings in Cognitive Neurology at Columbia University, Post-Doctoral Research Fellowship at Columbia University and Translational and Clinical Investigation at Rockefeller University in New York City, where she was an Assistant Professor of Clinical Investigation before moving to Mount Sinai. Clinically, Dr. Pereira evaluates patients at the Barbara and Maurice Deane Center for Wellness and Cognitive Health at The Mount Sinai Hospital, having expertise in diagnosing and treating neurodegenerative disorders and other cognitive syndromes. Dr. Pereira’s research focuses on furthering knowledge of the neurobiology of aging and Alzheimer’s disease, taking into account the selective vulnerability of glutamatergic neural circuits to synaptic changes in aging and neuronal loss in Alzheimer’s disease. She seeks to explore mechanisms underlying these susceptibilities along with effective therapeutic interventions. Simone Rossi, MD, PhD, Professor of Neurology, clinical neurophysiologist, leading the Brain Investigation & Neuromodulation Lab (Si-BIN Lab) at the Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Unit, University of Siena, where he also leads the Parkinson’s disease clinical activity. He is the author of popular books as “Il Cervello Elettrico” [The Electric Brain], “Il corpo artificiale. Neuroscienze e robot da indossare” [The Artificial Body. Neuroscience and wearable robots], Raffaello Cortina Ed. And “IO & IA. Mente, Cervello e GPT [I and AI. Mind, brain and GPT], Rubbettino Ed. Dr. Rossi is an international leader in the field of noninvasive brain stimulation, where his contributions include: technical developments (a new sham coil for TMS); use and developments of noninvasive brain stimulation techniques (TMS, tDCS, tACS) as neuroimaging procedures in cognitive neuroscience, with a focus on memory, therapeutic neuromodulatory tools in neuropsychiatry, and neuroehnancement (including ethical issues); individuation of neurophysiological markers of psychiatric diseases; noninvasive investigation of neural plasticity mechanisms and brain connectivity, studied with EEG, TMS-EEG combination and rsFMRI. Dr. Rossi has authored 250 full text publications on peer-reviewed scientific journals and has more than 30,000 citations. About Sinaptica Therapeutics Sinaptica Therapeutics is a clinical-stage neuromodulation therapeutics company leading the development of a new class of personalized therapeutics to revolutionize the treatment of Alzheimer’s and neurodegenerative diseases. The company utilizes a novel, noninvasive approach to treating Alzheimer’s via precision neurostimulation of a key brain network involved in memory, the Default Mode Network. This novel approach slowed disease progression by >80% on all four gold-standard cognitive and functional clinical endpoints in a placebo-controlled Phase 2 clinical study, with results published in the peer-reviewed Oxford University Press journal, Brain. The technology was granted Breakthrough Device Designation by the FDA in 2022 and the company is preparing for a pivotal randomized controlled clinical trial in early 2025. Sinaptica’s mission is to bring a safe, effective, and noninvasive neuromodulation therapy to Alzheimer’s patients that can help to significantly slow the progression of both cognitive and functional decline. Learn more at sinapticatx.com and follow us on LinkedIn and Twitter @SinapticaTX. The SinaptiStim™ System is for investigational use only. It has not been approved by the U.S. Food and Drug Administration and is not available for commercial sale in any geography.