A comparative study evaluating the efficacy and safety of tofacitinib tablet and betamethasone cream versus betamethasone cream in treatment of acral vitiligo in a tertiary care hospital of eastern India - NIL

Start Date08 Apr 2025

Sponsor / Collaborator

Bankura Sammilani Medical College

CTRI/2025/03/083239

/ Not yet recruitingNot Applicable

A comparative study evaluating the efficacy and safety of Crisaborole 2 percent ointment versus Betamethasone valerate 0.1 percent cream in Atopic dermatitis patients in a tertiary care hospital - NIL

Start Date01 Apr 2025

Sponsor / Collaborator

Bankura Sammilani Medical College

100 Clinical Results associated with Bankura Sammilani Medical College

0 Patents (Medical) associated with Bankura Sammilani Medical College

541

Literatures (Medical) associated with Bankura Sammilani Medical College

01 Apr 2025·INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH

COMPARISON OF SERUM LEVELS OF GLYCOSYLATED HAEMOGLOBIN AND FERRITIN IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC RETINOPATHY

Author: Sekhar Das, Surya ; Mondal, Anup ; Ghosh, Anik

Background: Diabetic retinopathy (DR) is a major microvascular complication of Type 2 Diabetes Mellitus (T2DM) and a leading cause of vision loss. Elevated serum ferritin levels, an indicator of iron overload and oxidative stress, have been implicated in the progression of DR. This study aimed to compare serum levels of glycated haemoglobin (HbA1c) and ferritin in T2DM patients with and without DR. Methods: A descriptive observational cross-sectional study was conducted from August 2022 to July 2023. A total of 72 diagnosed T2DM patients were selected and categorized into two groups: Group A (without DR, n=36) and Group B (with DR, n=36). Serum HbA1c and ferritin levels were measured and statistically analysed using Student's t-test, ANOVA, and correlation analysis. Results: The mean HbA1c level was significantly higher in patients with DR (8.37 ± 1.59%) compared to those without DR (5.85 ± 0.401%) (p<0.05). Similarly, serum ferritin levels were markedly elevated in DR patients (152 ng/mL) compared to non-DR patients (36.6 ng/mL) (p<0.05). Further subgroup analysis revealed a progressive increase in HbA1c and ferritin levels with the severity of DR, with the highest levels observed in patients with proliferative diabetic retinopathy (PDR). Conclusion: Elevated serum ferritin and HbA1c levels are significantly associated with the presence and severity of DR in T2DM patients. These biomarkers may serve as potential indicators for early detection and monitoring of DR progression.

01 Mar 2025·Medical Journal of Dr. D.Y. Patil Vidyapeeth

Prevalence of Diabetes, Hypertension, and Anemia with their Correlates in the Adult Population in a Tribal Block in Eastern India

Author: Sarkar, Aditya Prasad ; Lo, Sourav ; Biswas, Daliya ; Haldar, Dibakar

ABSTRACTContext:Noncommunicable diseases (NCDs) like diabetes, hypertension, and others are spreading like an epidemic over the world. Anemia is a significant public health problem. Tribal communities pay the least attention on chronic illnesses.Aims:To estimate the magnitude of diabetes, hypertension, and anemia with their correlates among the adult tribal population in Eastern India.Settings and Design:A community-based, descriptive study with a cross-sectional design was carried out in Hirbandh block, Bankura, West Bengal.Methods and Material:The study involved 210 participants, selected through cluster sampling, and collected information through house-to-house visits, interviews, clinical examinations, anthropometry, and lab investigations.Statistical Analysis Used:Analysis was done with the help of MS Excel and statistical software SPSS 20.0 version. Statistical tests were used with P value ≤ 0.05 and were considered significant with a 95% confidence interval.Results:One-fourth study participants were found to have diabetes and almost 23% of the participants had hypertension. Prevalence of anemic was 57.1%. Diabetes was associated with age, gender, and occupation of the participants. Hypertension was associated with age educational level, marital status, occupation, body mass index, and waist–hip ratio. Anemia was related to gender, joint family, and intake of green leafy vegetables.Conclusions:The prevalence of diabetes mellitus is rapidly rising all over the globe at an alarming rate. Improving the implementation of the current policy toward NCDs and anemia prevention and control will enhance the ability to address the multifactorial etiology of the above diseases within tribal populations and may reduce India’s disease burden.

01 Mar 2025·Indian Journal of Dermatology

Effectiveness, Tolerability and Safety of Topical Clobetasol with Oral Hydroxychloroquine versus Topical Clobetasol with NBUVB Phototherapy in Unstable Vitiligo: Investigator Blind, Randomized Controlled Trial

Article

Author: Sarkar, Pinaki ; Tarafdar, Dhiman ; Koley, Sankha ; Sil, Amrita ; Ghosh, Arghyaprasun ; Ray, Biswarup ; Das, Nilay K. ; Sen, Indrayudh

AbstractBackground:Vitiligo is an acquired multifactorial depigmentation disorder with dreadful social stigma without any gold standard treatment option. Treatment of unstable vitiligo is, furthermore limited. Hydroxychloroquine has shown promise in a few case reports.Objectives:The effectiveness, tolerability and safety of narrow-band ultraviolet B (NBUVB)-plus topical clobetasol (group A) versus oral hydroxychloroquine-plus topical clobetasol (0.05%) (group B) were evaluated.Methods:Single-centre, investigator-blind, randomised, active-controlled, parallel-group phase IV trial (CTRI/2019/07/020345) was conducted on unstable vitiligo of either sex. Patients were randomised into two groups (1:1 allocation ratio), and allocation concealment was ensured by the sequentially numbered, sealed, opaque envelope technique. The assessing physician was unaware regarding treatment allocation. Outcome measures were the vitiligo area scoring index (VASI), vitiligo disease activity score (VIDA) and dermatology life quality index (DLQI). The economic burden of therapy was calculated in terms of travel costs and loss of time for availing of the therapy. Routine haematological and biochemical tests and treatment-emergent adverse events were monitored for safety. The calculated sample size was 82 (5% alpha-error, 80% power, 61.1% and 30% percentage improvement in study groups, 10% drop-out).Results:Intention-to-treat analysis showed significant improvement in VASI (Friedman’s analysis of variance, P < 0.01) in group A (1048.00 ± 1450.10 reduced to 933.43 ± 1387.79) and group B (415.00 ± 458.47 reduced to 283.85 ± 386.61) at the end-of-treatment visit (24th week). Improvement was noted from 12 weeks onwards in group A and eight weeks onwards in group B (post-hoc Dunn’s test, P < 0.001). Within group comparison showed significantly more improvement in group B than group A from eight weeks onwards (P < 0.05, analysis of covariance test with baseline VASI as covariate). A similar result was obtained with VIDA. DLQI significantly improved only in group B. The monthly cost of travel and loss of time were significantly less (Mann-Whitney’s test, P < 0.5) in group B than group A. No adverse events were noted in either group.Conclusion:Both NBUVB and hydroxychloroquine combined with topical clobetasol are safe and effective agents in the treatment of vitiligo, though the improvement is more and faster with hydroxychloroquine. With hydroxychloroquine, there is no infrastructural requirement, less travel cost and less loss of working hours as opposed to NBUVB, which needs infrastructural set-up.

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100 Translational Medicine associated with Bankura Sammilani Medical College

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