Guangdong Wenjian Pharmaceutical Co.,Ltd.

Main study objectives To study the pharmacokinetics of the test preparation (T) Pinaverium Bromide Tablets (Specification: 50 mg, produced by Huayi Pharmaceutical Technology (Anhui) Co., Ltd., provided by Guangdong Wenjie Pharmaceutical Co., Ltd.) and the reference preparation (R) Pinaverium Bromide Tablets (trade name: Dicetel®, specification: 50 mg, Abbott Laboratories Limited) in healthy adult subjects after oral administration in the fed state, and to evaluate the bioequivalence of the two preparations. Secondary study objectives To evaluate the safety of the test preparation (T) Pinaverium Bromide Tablets and the reference preparation (R) Pinaverium Bromide Tablets (Dicetel®) after oral administration in healthy Chinese subjects in the fed state.

Primary objective: To study the pharmacokinetic (PK) characteristics of calcitriol in healthy Chinese subjects after a single oral administration of calcitriol capsules (specification: 0.25μg, Guangdong WenJian Pharmaceutical Co., Ltd.) and reference preparation (specification: 0.25μg, Rogaquan®; licensee: Roche Pharma (Schweiz) AG) in the fasting state, and to evaluate the bioequivalence of the two preparations in the fasting state. Secondary objective: To evaluate the safety of the test preparation and reference preparation of calcitriol capsules in healthy Chinese subjects after a single oral administration in the fasting state.

Primary objective: To study the pharmacokinetic (PK) characteristics of calcitriol in healthy Chinese subjects after a single oral administration of calcitriol capsules (specification: 0.25μg, Guangdong WenJian Pharmaceutical Co., Ltd.) and reference preparations (specification: 0.25μg, Rogaquan®; licensee: Roche Pharma (Schweiz) Ltd.) in fasting and fed states, and to evaluate the bioequivalence of the two preparations in fasting and fed states. Secondary objective: To evaluate the safety of the test preparation and reference preparation of calcitriol capsules in healthy Chinese subjects after a single oral administration in fasting and fed states.