Shenzhen Sinobioway Xinpeng Biomedicine Co., Ltd.

Voltage-gated sodium channel Na_V1.9 is preferentially expressed in peripheral nociceptors and plays an important role in the generation and propagation of elec. signals in nerves.Animal models and genetic studies have shown that it plays a major role in inflammatory pain, neuropathic pain and cold allodynia.Therefore, Na_V1.9 is a potential target for analgesics.Here, we review recent studies that reveal the relationship between Na_V1.9 and pain.Na_V1.9's expression location, physiol. characteristics, animal models, genetic validation in humans and pharmacol. study, and the development of targeted analgesics were discussed, to provide reference for the further research of the role of Na_V1.9 in pain.

Organoids are driven by stem cells in vitro to form multicellular three-dimensional structures with the micro-anatomical and self-renewing characteristics of the source organs.Organoids produce organ-specific cell types that can reproduce part of the function and spatial structure of the corresponding organs.They promote the development of life medicine research and have shown broad application prospects in cancer basic and clin. research, regenerative medicine and other fields.This review summarizes the research progress of organoids in recent years, including introducing its construction process and culture system and expounding its advantages and disadvantages as an in vitro research model, which provides a reference for scientific research and application based on organoids.