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Skin and Musculoskeletal Diseases

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Disease Domain	Count

Neoplasms	2

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Small molecule drug	2

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EGFR x PARP1	2

This study delves into the biol. characteristics of Clinopodium nepeta subsp. ascendens (CNEO) essential oil, an indigenous subspecies of eastern Morocco.Distinguished by its purple or pale pinkish-white flowers, CNEO was subjected to thorough phytochem. anal. via gas chromatog.-mass spectrometry (GC-MS), revealing 21 terpene compounds, notably Dihydrocarvone (22.70%), Neoisomenthol (43.59%), and Pulegone (20.55%).These compounds, recognized for their biol. and pharmacol. attributes, were further investigated for their potential applications.Notably, CNEO exhibited dose-dependent anti-inflammatory effects by attenuating nitric oxide (NO) and prostaglandin E2 (PGE2) productionMoreover, it demonstrated promising anticancer activity against MDA-MB-468, HepG2, and HCT-15 cancer cell lines, rivaling doxorubicin′s effectiveness.These findings underscore CNEO′s nutraceutical potential, particularly in food science and industry, suggesting its use as a functional food additive with both nutritional and health benefits

31 Dec 2024·International Journal of Food Properties

Physicochemical and phytochemical characterization of opuntia dillenii : A promising source of bioactive compounds

Author: Mohammed, Ramdani ; Kadda, Salma ; El Hassania, Loukili ; Bourhia, Mohammed ; Salamatullah, Ahmad Mohammad ; Hbika, Asmae ; Mohammed, Bouslamti ; Dauelbait, Musaab ; Mohamed, Taibi ; Fauconnier, Marie-Laure ; Elbouzidi, Amine

The objective of this ongoing research is to investigate and assess the aqueous extracts, vegetable oil, and residual plant components derived from O. dillenii by use of HPLC, and GC-MS.Subsequent investigations employed colorimetric techniques to identify reducing and soluble sugars.We developed and validated an energy-dispersive X-ray fluorescence (EDXRF) method for determining the concentrations of essential chem. elements (O, C, Ca, Mg, K, S, P) in seeds, juice, and peel, as well as their residues.HPLC anal. yielded results indicating that extracts from O. dillenii seeds, juice, and peel from distinct regions (Oujda, Nador, and Essaouira) contained elevated concentrations of metabolites.Specifically, peel and juice extracts exhibited the highest levels of organic acids and betanin compared to O. dillenii seeds.Conversely, seed oils displayed a noteworthy tocopherol content, predominantly δ-tocopherol.Similarly, an examination of organic acid composition in juice, peel, and seeds from three different regions revealed their elevated levels.Citric acid and oxalic acid emerged as predominant components in the juice.Overall, Opuntia dillenii's physicochem. and phytochem. characterization improves in understanding its potential as a bioactive chem. promoter, which could lead to the creation of new medicinal medicines or functional food ingredients.

01 Dec 2024·Current Chemical Biology

Use of Essential Oils for the Treatment of Fusarium oxysporum f. sp. Albedinis: Chemical Profile, In Vitro Antifungal Activity, and In Silico Investigation by Molecular Docking Study

Author: Touzani, Rachid ; Diass, Khaoula ; Benabbas, Redouane ; Oualdi, Imane ; Hammouti, Belkheir ; Zaki, Hanane ; Bouachrine, Mohammed ; Ouabane, Mohamed

Background:Fusarium oxysporum f. sp. Albedinis a telluric fungal pathogen commonly found in soils, is the causal agent of fungal vascular wilt of date palms in Moroccan oases. The infection by the pathogen leads to the death of the date palm after six months to two years, which causes enormous economic and environmental damage.Objective:The framework of this paper is to determine the chemical composition of six essential oils using GC-MS and their antifungal activity on the mycelial growth of Fusarium oxysporum f. sp. Albedinis, as well as the molecular docking study to evaluate the inhibitory potential of fungal trypsin.Methods:The essential oils were extracted from different parts of the plants (whole plant, flowers, and leaves) by steam distillation, and were identified using gas chromatography-mass spectrometry (GC/MS). The antifungal assay of the extracted essential oils and their main components was assessed using the direct contact method with the fungus at different concentrations; the obtained results were evaluated by calculating the minimum inhibitory concentration (MIC) of each essential oil, followed by an in-silico study of the major identified compounds for better understanding of the inhibitory potential against fungal trypsin activity.Results:The identification of the different bioactive compounds using GC-MS revealed that Rosmarinus officinalis Eo was characterized by eucalyptol 46.26%, camphor 10.03%, and β-pinene 6.63%; while Lavandula officinalis Eo was endowed by the presence of linalool 14.93%, camphor 14.11%, and linalyl acetate 11.17%. Furthermore, Artemisia herba alba was rich in 1,3,5-cycloheptatriene, 1,6- dimethyl- 36.44%, camphor 22.50%, and α-thujone 7.21%. While Eucalyptus globulus was rich in eucalyptol 74.32%, β-Cymene 11.41%, α-Pinene 6.96%. Finally, Mentha pepirita and Mentha pulegium were both characterized by the presence of D-limonene 20.15%, trans-carveol 19.59%, D-Carvone 14.96%, and pulegone (42.40%), 3-cyclopentene-1-ethanol, 2,2,4-trimethyl- (11.28%), 1,3,4- trimethyl-3-cyclohexenyl-1-carboxaldehyde (9.68%), respectively. Regarding the in vitro, all Eos from different plants exhibited pronounced antifungal effect. The MIC values recorded for E. globulus were MIC= 1.75 mg/L, M. pulegium and L. officinalis (MIC= 1.80 mg/L), and M. piperita (MIC= 1.90 mg/L). The strongest inhibition potential was associated with R. officinalis EO (MIC= 1.15 mg/L) and A. herba alba EO (MIC= 1.60 mg/L). As for the computational study performed camphor one of the bioactive compounds showed its ability to act against trypsin which could be considered a potential candidate against Fusarium oxysporum f. sp. Albedinis.Conclusion:The studied essential oils from different medicinal and aromatic plants showed significant antifungal activity, probably due to the Camphor which could have an inhibitory effect on the Fusarium oxysporum f. sp. Albedinis trypsin. Further research should be conducted in vivo for a better understanding of the mechanism of action of these essential oils.

100 Deals associated with Euro-Mediterranean University of Fes

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100 Translational Medicine associated with Euro-Mediterranean University of Fes

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Pipeline

Pipeline Snapshot as of 05 Jul 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Compounds 9(Euromed University of Fes) ( EGFR x PARP1 )	Triple Negative Breast Cancer More	Preclinical
Compounds 8(Euromed University of Fes) ( EGFR x PARP1 )	Triple Negative Breast Cancer More	Preclinical