Hainan Selection Pharmaceutical Co. Ltd.

Main study objectives: To investigate the relative bioavailability of a single oral dose of 60 mg (fasting/after meals) of the test preparation dapoxetine hydrochloride tablets (specification: 60 mg, produced by Hainan Celic Pharmaceutical Co., Ltd.) and the reference preparation dapoxetine hydrochloride tablets (trade name: Priligy®, specification: 60 mg, licensed by Berlin-Chemie AG, produced by Menarini-Von Heyden GmbH) in healthy adult male subjects in China, analyze the pharmacokinetic parameters of the two preparations, and evaluate the bioequivalence of the two preparations. Secondary study objectives: To evaluate the safety of a single oral dose of the test preparation and the reference preparation in healthy adult male subjects in China on an empty stomach/after meals.

To study whether there are differences in the extent and rate of absorption of the test preparation acetylcysteine tablets (Hainan Celic Pharmaceutical Co., Ltd., specification: 0.6g) and the reference preparation acetylcysteine tablets (trade name: Fluimucil®, specification: 0.6g) after a single oral administration to healthy subjects after a meal, to evaluate the bioequivalence of the test preparation and the reference preparation when administered in the fed state, and to observe the safety of the test preparation and the reference preparation in healthy subjects.

Main study objectives: To investigate the pharmacokinetic characteristics of the test preparation Telmisartan Amlodipine Tablets (Specifications: 80mg/5mg, produced by Hainan Selike Pharmaceutical Co., Ltd., provided by Hainan Selike Pharmaceutical Co., Ltd.) and the reference preparation Telmisartan Amlodipine Tablets (Twynsta®, Specifications: 80mg/5mg, certified by Boehringer Ingelheim International GmbH, provided by Hainan Selike Pharmaceutical Co., Ltd.) in healthy adult Chinese subjects, and to evaluate the bioequivalence of the two preparations in fasting and fed states. Secondary study objectives: To evaluate the safety of the test preparation and the reference preparation in healthy adult Chinese subjects after a single oral administration (fasting/fed).