Delving into the Latest Updates on School of Biotechnology with Synapse

Overview

Tags

Infectious Diseases

Respiratory Diseases

Neoplasms

Proteolysis-targeting chimeras (PROTAC)

Small molecule drug

Chemical drugs

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	2
Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	1
Proteolysis-targeting chimeras (PROTAC)	1
Chemical drugs	1

Top 5 Target	Count

DHODH(Dihydroorotate dehydrogenase)	1
SOS1(Son of sevenless homolog 1)	1

The sensing effect transformation is first exploited by microstructural modulation. Two AIE functional ligands L-1 and L-2 were developed to construct two isomorphic coordination polymers [Cu(L-1)₂(SCN)₂]_n (1) and [Cu(L-2)₂(SCN)₂]_n (2), respectively (L-1 = 4,4'-((9H-fluoren-9-ylidene)-methylene)dipyridine; L-2 = 5,5'-((9H-fluoren-9-ylidene)-methylene)dipyrimidine). 1 and 2 exhibit 1-D single-chain architectures and have good water, pH, and thermal stabilities. 1 and 2 show the functional-ligand-originated luminescence and reduced emission intensities. L-1 and L-2 stack in a back-to-back manner in 1 and 2 with the distances of 4.61 and 5.38 Å, resulting in distinct MnO₄^- sensing effects for 1 and 2. 1 exhibits "turn-off" (luminescence quenching) MnO₄^- sensing. In a sharp contrast, 2 shows "turn-on" (luminescence enhancing) MnO₄^- sensing ability with ultrahigh sensitivity. Particularly, 2 represents the first "turn-on" MnO₄^- sensor. Their sensing mechanism toward a distinct MnO₄^- sensing effect is discussed in detail.

16 Apr 2025·Journal of Agricultural and Food Chemistry

Reconstructing Candida glycerinogenes Metabolism to Efficiently Synthesize (−)-α-Bisabolol

Article

Author: Lu, Xinyao ; Zhuge, Bin ; Du, Xueqing ; Zong, Hong

(-)-α-Bisabolol is one of the important derivatives in the mevalonate (MVA) pathway. Yeast not only possesses a complete MVA metabolic pathway but also has mature modification and optimization strategies, among which transcription factor regulation is a very effective method. In this study, by screening transcription factors associated with the MVA pathway, a new regulatory factor, ECM22, was discovered that can be used for terpenoid synthesis, and ECM22 proved to be the most effective compared to other screened transcription factors. Previous studies have indicated that ECM22 is related to sterol synthesis, as it enters the nucleus through its N-terminal domain to recognize and bind to sterol regulatory elements (SREs) on promoters, thereby activating the transcriptional activity of target genes. Based on the characteristics of this transcription factor, we achieved fine-tuning of (-)-α-bisabolol synthesis by optimizing sterol elements and varying sterol content, resulting in a 280% diversion of carbon flux toward (-)-α-bisabolol synthesis. This is the first time ECM22 has been utilized in the terpenoid synthesis process, allocating the largest metabolic flux to the synthesis pathway of terpenoids. Ultimately, we obtained 1442.22 mg/L of (-)-α-bisabolol through fed-batch fermentation in a 5 L bioreactor, advancing the precise directional regulation of terpenoid metabolic engineering.

14 Apr 2025·Inorganic Chemistry

Modulation of S and N Active Sites for Coordination Polymers to Achieve Enhanced Hg²⁺ Sensing Performances

Article

Author: Tao, Xingyu ; Yin, Dejing ; Zhang, Jinfang ; Zhang, Chi ; Yue, Yinlong

It is challenging and vital to develop coordination polymers (CPs) with an outstanding sensing performance. In this work, CP-based sensors with active S and N sites are first exploited. Three new Cu-CPs [Cu(L)(SCN)₂·2DMF]_n (1), [Cu(L)(SCN)·2DMF]_n (2), and [Cu(L)(CN)·2DMF]_n (3) were successfully synthesized by 9,10-bis(di(pyrimidin-5-yl)methylene)-9,10-dihydroanthracene (L) and SCN^-/CN^- ligands. 1 demonstrates a 1D wavelike chain, fabricated by L bridges linking with Cu(SCN)₂ units. 2 exhibits a 2D (3,3)-connected network fabricated by SCN^-, 3-connected L, and Cu units. 3 exhibits a 3D framework, built by 4-connected Cu centers, CN^-, and L bridges. 1-3 have good water, pH, and thermal stabilities. 1 and 2 have uncoordinated S and N active sites and can detect Hg²⁺ through the fluorescence enhancing ("turn-on") effect. Meanwhile, 3 only has uncoordinated N active sites and shows a negative Hg²⁺ sensing ability. 1 and 2 have ultrahigh Hg²⁺ sensing sensitivity and selectivity. The K_SV and LOD of 1 toward Hg²⁺ are about 3 and 5 times superior to those of 2, separately. 1 and 2 represent the first S- and N-rich CP-based sensors and exhibit an excellent "turn-on" Hg²⁺ sensing capacity. Their "turn-on" Hg²⁺ sensing mechanism and difference sensing performances are discussed in detail.

100 Deals associated with School of Biotechnology

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100 Translational Medicine associated with School of Biotechnology

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Pipeline

Pipeline Snapshot as of 13 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

2

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

S-416 ( DHODH )	COVID-19 More	Preclinical
(Gly0.8Nap0.2)20	Candidiasis More	Preclinical
SOS1 PROTAC(Huadong Polytechnic University) ( SOS1 )	Neoplasms More	Preclinical
DWP-0016 ( HDACs x p53 )	Glioblastoma More	Pending
S-312(Huadong Polytechnic University) ( DHODH )	COVID-19 More	Pending