Delving into the Latest Updates on School of Biotechnology with Synapse

Overview

Tags

Infectious Diseases

Neoplasms

Respiratory Diseases

Small molecule drug

Synthetic peptide

Proteolysis-targeting chimeras (PROTAC)

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	4
Neoplasms	2
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	3
Proteolysis-targeting chimeras (PROTAC)	1
Synthetic peptide	1
Chemical drugs	1

Top 5 Target	Count

DHODH(Dihydroorotate dehydrogenase)	2
SOS1(Son of sevenless homolog 1)	1
HDACs x p53	1

The DNA content, PCNA and P53 expression in vulva lichen sclerosus and their relationship with cell proliferation were studied.The expression of P53 gene protein and proliferating cell nuclear antigen (PCNA) were detected by immunohistochem. technique and size and DNA content of the basal cell nuclei were measured by an automatic color image anal. system in 20 patients with vulva lichen sclerosus and 10 specimens of normal vulva skin.The result showed that compared with normal skin, in lichen sclerosus, PCNA expression was higher, but had no statistically significant difference (P>0.05); P53 expression was higher; the size of the basal cell nuclei and the DNA content were decreased (P<0.05).The most pos. expression showed in the prickle and granular cells.The vulva lichen sclerosis were related to abnormal cell proliferation.

100 Deals associated with School of Biotechnology

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100 Translational Medicine associated with School of Biotechnology

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Pipeline

Pipeline Snapshot as of 27 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

6

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

DWP-0016 ( HDACs x p53 )	Glioblastoma More	Preclinical
(Gly0.8Nap0.2)20	Cryptococcosis More	Preclinical
βLys50HG50	MRSA - Methicillin resistant Staphylococcus aureus infection More	Preclinical
S-312(Huadong Polytechnic University) ( DHODH )	COVID-19 More	Preclinical
SOS1 PROTAC(Huadong Polytechnic University) ( SOS1 )	Neoplasms More	Preclinical