Efficacy and equity of exercise combined with education delivered via telehealth compared to in person for improving pain intensity and disability in chronic non specific low back pain: TECLI study with economic evaluation - TECLI Telehealth in Chronic nonspecific Low back pain

Start Date21 Aug 2025

Sponsor / Collaborator

Universidade Federal dos Vales do Jequitinhonha e Mucuri

[+1]

RBR-2sgn9cy

/ Not yet recruitingNot ApplicableIIT

Effectiveness of Wise Infant Development® software in the acquisition of knowledge about infant development among nursing students: a randomized controlled clinical trial

Start Date01 Feb 2025

Sponsor / Collaborator

Universidade Federal do Ceará

[+1]

RBR-10k3srtd

/ Not yet recruitingNot ApplicableIIT

Effectiveness of Educational Technology to Prevent Falls in the hospital: randomized clinical trial

Start Date01 Jan 2025

Sponsor / Collaborator

Universidade Federal do Ceará

[+1]

100 Clinical Results associated with Universidade Federal do Ceará

0 Patents (Medical) associated with Universidade Federal do Ceará

39,740

Literatures (Medical) associated with Universidade Federal do Ceará

01 Dec 2025·Immunogenetics

Analysis of Complement Factor H gene polymorphisms and their association with clinical manifestations ofleptospirosis

Article

Author: Meneses, GdayllonCavalcante ; Santiesteban-Lores, Lazara Elena ; Hibi, Sumire ; de Oliveira, Luciano Marcondes ; Isaac, Lourdes ; Pontillo, Alessandra ; Fonseca, Denise Moraes ; Midon, Leonardo Moura ; Chiani, Yosena ; De Francesco Daher, Elizabeth ; Franco, ThirsaAlvares

Leptospirosis is caused by pathogenic leptospires, posing a significant public health problem. Host susceptibility to Leptospira infection is a multifactorial trait, and the host's genetic background can influence both the establishment of infection and the severity of the disease. Complement Factor H (FH) plays a crucial role in the interaction between pathogenic bacteria and the host. Genetic variants in the FH gene CFH have previously been associated with non-infectious diseases. Here, we aimed to analyze the effect of CFH variants on individual susceptibility to leptospirosis and disease severity. To accomplish this, we sequenced CFH exons 7, 9, 21, 22, and 23 in a case/control cohort (184/162) from two endemic leptospirosis areas in Brazil and Argentina. We identified twenty-one single nucleotide variants (SNVs). In the Brazilian cohort, the intronic variant rs34815383 exhibited a higher frequency in patients than in controls, resulting in a significant association with leptospirosis (p = 0.032; OR: 0.32; 95% CI 0.1-1) and also renal disorder (p = 0.001; OR: 5.3; 95%CI 1.8-15.57). This SNV is reported to be a splicing variant, negatively impacting CFH expression, and has previously been associated with Complement-driven renal disease. A second synonymous variant, rs61822181, was significantly less frequent in patients than in controls (p = 0.002; OR: 7.33; 95% CI 1.59-33.7), representing a protective factor against the development of leptospirosis. Our study represents the first documentation of the frequency of CFH SNVs in South America and identifies the variant rs34815383 T > C as a risk factor for leptospirosis and leptospirosis-related renal complications.

01 Dec 2025·Journal of Gastrointestinal Cancer

Anti-EGFR Rechallenge in Metastatic Colorectal Cancer and the Role of ctDNA: A Systematic Review and Meta-analysis

Review

Author: Saldanha, Erick Figueiredo ; da Silva, Marcos Vinícius Martins Grangeiro ; Peixoto, Renata D 'Alpino ; Noronha, Mariana Macambira ; da Silva, Luís Felipe Leite ; da Conceição, Lucas Diniz

BACKGROUNDMetastatic colorectal cancer (mCRC) remains a significant clinical challenge. While anti-EGFR inhibitors have improved survival rates, their long-term efficacy is limited by disease progression, which is often associated with the development of acquired resistance mutations. However, some patients may regain sensitivity to anti-EGFR agents after alternative therapies, suggesting a potential benefit for rechallenge strategies. Our study aims to conduct a systematic review and meta-analysis to comprehensively evaluate the efficacy and safety of EGFR rechallenge in patients with mCRC.METHODSA systematic search of the MEDLINE, EMBASE, and Cochrane databases was conducted between October 28 and December 24, 2023, to identify clinical trials investigating treatment regimens incorporating panitumumab or cetuximab as a rechallenge strategy. Pooled proportions or hazard ratios (HR) were calculated using a random effects model. Inter-study heterogeneity was assessed using the I².RESULTSAmong the 2105 articles identified through the search, 13 met the predetermined inclusion criteria. Of these, 12 were phase II studies, encompassing 92.3% of the patient population. Cetuximab was administered to 302 patients (75.1%), whereas panitumumab was utilized in 100 patients (24.9%).A pooled analysis of eight studies demonstrated an objective response rate of 20.50% (95% CI 7.94 to 33.07) and a disease control rate of 67.35% (95% CI 58.60 to 76.09). The median progression-free survival was estimated at 3.5 months (95% CI 2.68-6.69), with a median OS of 9.8 months (95% CI 6.71-12.89). Patients exhibiting RAS wild-type status in circulating tumor DNA (ctDNA) analysis derived enhanced benefits from anti-EGFR rechallenge (HR: 0.41; 95% CI 0.28-0.60, I² = 60%). Common grade 3 or higher treatment-related adverse events included neutropenia (22.8%) and rash (14.9%).CONCLUSIONThis meta-analysis underscores the efficacy and safety of anti-EGFR rechallenge as a promising therapeutic approach for a subset of patients afflicted with mCRC. The observed correlation between wild-type RAS status, as determined through ctDNA analysis, and improved OS signals the prospect of precision oncology in guiding treatment decisions.

01 Jun 2025·Morphologie

Knowledge of gross human anatomy among Brazilian physical education students: A cross-sectional study

Article

Author: de Oliveira, F B ; Pessoa, K J N ; de Lima, A C ; de Lira, C A B ; Santos, D A T ; Machado, H R ; Ribeiro, J M ; Viana, R B ; Barbosa Neto, O ; da Silva, C K C ; de Sousa, C E V ; da Silva, J A

BACKGROUNDGross human anatomy is essential in undergraduate programs across biological and health sciences. While extensive literature explores medical students' knowledge in this area, studies on non-medical students, particularly those in physical education, are scarce.OBJECTIVEThis study assessed the anatomy knowledge among Brazilian physical education students and explored differences based on employment status, type of class instruction (face-to-face vs. online), and involvement in academic activities. Additionally, we investigated students' perceptions of the assessment instrument and the gross human anatomy course itself.METHODSWe conducted a cross-sectional study involving physical education students of both sexes, aged 18 and older, from four public Brazilian universities. Participants completed a 15-question multiple-choice survey on human anatomy systems. Correct answers received one point, with a total potential score of 15 points (100%). We categorized scores as excellent (≥ 90%), good (71-89%), sufficient (50-70%), and insufficient (< 50%). Participants had 90minutes to complete the survey. We presented data as median and interquartile range [IQR], median difference (Δ), and 95% confidence intervals. Scores were compared against the median absolute (7.5 points) and relative (50%) values. We used rank-biserial correlation for effect size and set a significance level 0.05. The study included 216 students (143 males) with a median age of 22.4 years [IQR: 4.0].RESULTSThe final scores were significantly above the cut-offs, with a median absolute score of 9.0 [IQR: 3.0] and a relative score of 60% [IQR: 20%], showing large effects (Δ: +2.0 [1.5-2.0], P<0.001; Δ: +13.33% [10.0-13.34%], P<0.001). There were no significant differences in either the absolute or relative final scores (P≥0.05) between students who participated in academic activities and those who did not, nor between students who attended face-to-face versus online gross human anatomy classes. However, we found a significant difference between non-working students and their employed counterparts, with non-workers scoring higher both absolutely (P=0.002) and relatively (P=0.002) on the gross human anatomy questionnaire. Most of the participants described the difficulty of the gross human anatomy questionnaire as "average" (51.39%, n=111) and rated the gross human anatomy course difficulty as "difficult" (52.8%, n=114).CONCLUSIONBrazilian physical education students demonstrated only sufficient knowledge in gross human anatomy (60%). Therefore, strategies to enhance or maintain their knowledge throughout the educational program are vital.

100 Deals associated with Universidade Federal do Ceará

100 Translational Medicine associated with Universidade Federal do Ceará

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