Information integration service interface management can be used to design the complete business process closed-loop of each business line according to the logic of different business lines in different specialized information systems in pharmaceutical enterprises. An enterprise service bus can manage multiple interfaces in a standardized, secure and efficient manner. In this paper, the information integration service interface management based on enterprise service bus is discussed; some principles, norms and processes summarized in practice are explained; some experiences, lessons, highlights, improvement methods and innovative practices are also introduced. The methods of "seamless connection" and interface switch are analyzed emphatically.