Delving into the Latest Updates on Tabriz University of Medical Sciences with Synapse

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Endocrinology and Metabolic Disease

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Endocrinology and Metabolic Disease	1
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Small molecule drug	1

Introduction:Coating of dental implants with nanoparticles can lead to improved fixation of implants.Aim:The aim of this study was to review the reported antimicrobial nano-coatings of Ti surfaces (dental implants) for anti-inflammatory, tissue integration, and osteogeneration aims.Methods:The data were collected from Google Scholar, PubMed, and Scopus sources.Results:The results showed that the antimicrobial nano-coatings of Ti surfaces exhibited a reduction in initial bacterial adhesion, concomitantly with an increase in the attachment of human gingival fibroblasts. In addition, the application of these surfaces resulted in anti-inflammatory effects with different mechanisms. Some nano-coated titanium surfaces have also shown enhanced hydrophilicity and corrosion resistance, aiding the adhesion and proliferation of osteoblasts.Conclusion:Coating Ti surfaces with antimicrobial nanoparticles can improve soft tissue integration and osteogeneration, leading to improved fixation of implants. Moreover, such coatings may profit biocompatible surfaces with a controlled release profile for the antimicrobial agents.

01 Feb 2025·Non-coding RNA Research

Biological functions and affected signaling pathways by Long Non-Coding RNAs in the immune system

Review

Author: Karimi, Bahareh ; Valizadeh, Sepehr ; Ghaedi, Kamran ; Almanghadim, Hossein Ghahramani ; Ghahramani Almanghadim, Hossein

Recently, the various regulative functions of long non-coding RNAs (LncRNAs) have been well determined. Recently, the vital role of LncRNAs as gene regulators has been identified in the immune system, especially in the inflammatory response. All cells of the immune system are governed by a complex and ever-changing gene expression program that is regulated through both transcriptional and post-transcriptional processes. LncRNAs regulate gene expression within the cell nucleus by influencing transcription or through post-transcriptional processes that affect the splicing, stability, or translation of messenger RNAs (mRNAs). Recent studies in immunology have revealed substantial alterations in the expression of lncRNAs during the activation of the innate immune system as well as the development, differentiation, and activation of T cells. These lncRNAs regulate key aspects of immune function, including the manufacturing of inflammatory molecules, cellular distinction, and cell movement. They do this by modulating protein-protein interactions or through base pairing with RNA and DNA. Here we review the current understanding of the mechanism of action of lncRNAs as novel immune-related regulators and their impact on physiological and pathological processes related to the immune system, including autoimmune diseases. We also highlight the emerging pattern of gene expression control in important research areas at the intersection between immunology and lncRNA biology.

01 Feb 2025·Current Nutrition & Food Science

Enteral Feeding Dilemmas: Navigating the Impact of Bacterial Contamination in Hospitalized Populations

Author: Sarmadian, Amirreza Jabbaripour ; Mahboobi, Hamidreza ; Fatemizadeh, Somayeh ; Kamal, Mohammad Amjad ; Moghtadaie, Atie

Introduction:Enteral feeding is essential for hospitalized patients unable to consume oral nutrition. However, it poses a risk of bacterial contamination, leading to infections and increased morbidity and mortality.Method:Studies have shown that contaminated enteral feeds are associated with longer hospital stays and worsened patient outcomes. Common pathogens include Gram-negative bacilli (e.g., Serratia spp., Klebsiella spp., Enterobacter spp.), coagulase-negative staphylococci, and Clostridium difficile. Preventing contamination requires identifying and mitigating potential routes. This comprehensive approach encompasses careful practices during production, storage, preparation, and administration of enteral feeds.Result:Early initiation of enteral feeding has also been linked to lower infection rates. Standardized protocols, hand hygiene adherence, routine monitoring for infection signs, and ongoing staff education are crucial for safe enteral feeding. Further research is needed to better understand risk factors for contamination and evaluate the effectiveness of preventive interventions.Conclusion:Addressing these knowledge gaps can significantly improve the quality of enteral feeding and reduce infection burden in hospitalized patients.

100 Deals associated with Tabriz University of Medical Sciences

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100 Translational Medicine associated with Tabriz University of Medical Sciences

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Pipeline

Pipeline Snapshot as of 05 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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