Effect of knack maneuver with or without diaphragmatic breathing on urinary tract symptoms and quality of life among patients of stress urinary incontinence

Start Date22 Jul 2024

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Rashid Latif Medical College

100 Clinical Results associated with Rashid Latif Medical College

0 Patents (Medical) associated with Rashid Latif Medical College

204

Literatures (Medical) associated with Rashid Latif Medical College

01 Dec 2024·Cellular Signalling

Recent progress of protein kinase inhibitors derived from marine peptides for developing anticancer agents

Article

Author: Farooqi, Ammad Ahmad ; Liu, Xiujun ; Xu, Yixin ; Blundell, Renald ; Lin, Xiukun ; Zheng, Lanhong ; Zhang, Yan ; Wei, Ning

Protein kinases, mediating their biological function via their catalytic activity, play important role in cell development, including cell proliferation, migration, angiogenesis and survival. Over the years, protein kinase inhibitors have been developed as an important class of anticancer agents clinically. However, the off-targeting and drug resistance of protein kinase inhibitors limit their efficiency. Anticancer peptides derived from marine organisms represent a novel class of bioactive substances, and some of the peptides exhibit anticancer effect via inhibiting protein kinases. In this mini review, the recent progress of anticancer peptides targeting protein kinases from marine sources are presented. Marine peptides inhibiting resistant cancer cells by targeting novel domains of protein kinases are highlighted. The challenges and prospects of developing marine peptides as anticancer agents are also discussed.

09 Aug 2024·Journal of Back and Musculoskeletal Rehabilitation

Translation, cross-cultural adaptation and psychometric properties of the Urdu version of the avoidance endurance behavior questionnaire in patients with chronic musculoskeletal pain

Article

Author: Qurat-Ul-Ain, Asifa ; Fatima, Sahar ; Asif, Mohammad Musa ; Farooq, Ayesha Ahmad ; Zaheer, Anna ; Arslan, Syed Asadullah

BACKGROUND: The Avoidance Endurance Questionnaire (AEQ) successfully measures the fear-avoidance and endurance-related responses to chronic pain. OBJECTIVE: The objective of this study was to translate, cross-culturally adapt AEQ into Urdu and assess the reliability and validity of the Urdu version. METHOD: For the translation and cross-cultural adaptation process, the Beaton Guidelines were followed. A total of 103 participants responded to the Urdu version of the AEQ SF-12, Pain Catastrophizing Scale (PCS) and Numeric Pain Rating Scale (NPRS) at baseline and after 48 hours. The test-retest reliability was assessed using the intraclass correlation coefficient (ICC). Cronbach’s alpha was used to measure internal consistency. To measure validity, Pearson’s correlation between the subscales of AEQ-Urdu and other outcome measures (SF-12, PCS and NPRS scores) were used (p< 0.05). RESULTS: The mean age of the total 103 participants was 32.7 ± 10.90 among which 45 (43.6%) were male and 58 (56.3%) were female. The pre-final version of the translated AEQ was tested on 40 Urdu speaking participants and no major changes were made. The Cronbach’s alpha for all subscales of the AEQ-Urdu ranged from 0.848–0.990. AEQ-U showed an excellent test-retest reliability with the ICC ranging from 0.775–0.996. The majority of the subscales of AEQ showed significant (p< 0.05) positive correlation with pain scales (PCS and NPRS) and negative correlation with the domains of SF-12. CONCLUSION: The AEQ-U has reliable and valid construct validity, good internal consistency, and test-retest reliability, indicating that it has adequate psychometric features and can be a useful tool for evaluating pain responses in patients with chronic musculoskeletal pain.

01 Jul 2024·Heliyon

Analysis of the expression patterns of AVP, IGF-1, and TNF-α, APP, CD44, IFN-β IFN A β-6, α-syn, and NFL and CLU genes in generalized and focal seizures

Article

Author: Shabbir, Hamza R. ; Mukhtar, Shahid ; Bashir, Shahid ; Amin, Rehab ; Razia, Rabat ; Shabbir, Hamza R ; Noreen Baig, Deeba ; Mahmood, Khalid ; Ayub, Mariam Nisar ; Majeed, Fazeel

ObjectiveThe aim of our study was to investigate the relationship between clinical indicators and gene dysregulation in different types of epilepsy, while also seeking to identify a diagnostic model capable of distinguishing between focal and generalized seizures. This highlights the critical importance of understanding clinical indicators and gene dysregulation for targeted therapeutic interventions to effectively address the specific seizure types effectively.Materials and methodsIn this study, we conducted a comprehensive analysis of the peripheral blood of epilepsy patients (n = 100) and a control group (n = 51) to determine the differential gene expression. Our analysis involved a range of statistical approaches, including correlation analysis to establish the association between clinical indicators and gene dysregulation, and principal component analysis to highlight distinct disease group from control group. Furthermore, we developed diagnostic models using logistic regression to aid in the accurate diagnosis of epilepsy.ResultsAmong several selected genes in this study such as AVP (AUC = 0.832, p < 0.0001), IGF-1 (AUC = 0.658, p = 0.0015), TNF-α (AUC = 0.8970, p < 0.0001), APP (AUC = 0.742, p < 0.0001), CD44 (AUC = 0.614, p = 0.021) and NfL (AUC = 0.937, p < 0.0001), and CLU (AUC = 0.923, p < 0.0001) have shown the outstanding discrimination. In addition to this, when all genes were included in the model, the overall diagnostic power increased significantly (AUC = 0.9968). A differential diagnostic model for focal and generalized seizures was established which discloses AUC = 0.7027, (95 % CL, 0.5765 to 0.8289, p = 0.0019).ConclusionThe conclusions drawn from these findings represented that this is the first study to highlight the distinctive gene patterns of both focal and generalized seizures, implying that peripheral blood can serve as a diagnostic source to distinguish between these seizures types, aiding in the accurate classification of epilepsy. The findings from this study indicate a promising direction for investigating more targeted pharmacological interventions directed to address the distinct needs of both focal and generalized epilepsy, which offers advancements in treatment strategies for distinctive seizure types.

100 Deals associated with Rashid Latif Medical College

100 Translational Medicine associated with Rashid Latif Medical College

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