Comparison of Verapamil With Adenosine After Vagal Maneuvers in Patients Presenting With Paroxysmal Supraventricular Tachycardia (pSVT), in a Tertiary Care Hospital of Lahore, Pakistan

Supraventricular tachycardia (SVT) is a term widely used to describe tachycardial dysrhythmias, paroxysmal SVT (PSVT) is a narrow term including only AV nodal re-entrant tachycardia (AVNRT) and atrioventricular re-entrant tachycardia (AVRT), both of which can cause discomfort and, in some cases, life-threatening symptoms.
Usually Carotid sinus massage is done to lower the pulse rate and after the standard time specific verapamil dose is administered. In this study after carotid sinus massage Conventional Valsalva or modified Valsalva maneuver will be randomly applied. In case, the normal sinus rhythm (NSR) is not achieved then verapamil of or adenosine dose will be administered to the patients after after taking the consent.

Start Date28 Oct 2024

Sponsor / Collaborator

Rashid Latif Medical College

[+1]

IRCT20221205056713N3

/ RecruitingNot ApplicableIIT

Combined Effects of Retro Walking Exercises and Clamshell Exercises on Pain, Strength and Balance among Osteoarthritis Patients

Start Date25 Jul 2024

Sponsor / Collaborator

Rashid Latif Medical College

IRCT20221205056713N2

/ RecruitingNot ApplicableIIT

Effectiveness of JANDAS approach Versus McKenzie retraction exercises on pain, disability and quality of life among chronic neck pain patients

Start Date23 Jul 2024

Sponsor / Collaborator

Rashid Latif Medical College

100 Clinical Results associated with Rashid Latif Medical College

0 Patents (Medical) associated with Rashid Latif Medical College

222

Literatures (Medical) associated with Rashid Latif Medical College

01 Dec 2024·Cellular Signalling

Corrigendum to “Recent progress of protein kinase inhibitors derived from marine peptides for developing anticancer gents” [Cellular Signalling 124 (2024) 111411]

Author: Farooqi, Ammad Ahmad ; Lin, Xiukun ; Zheng, Lanhong ; Blundell, Renald ; Zhang, Yan ; Liu, Xiujun ; Xu, Yixin ; Wei, Ning

01 Dec 2024·Cellular Signalling

Recent progress of protein kinase inhibitors derived from marine peptides for developing anticancer agents

Review

Author: Farooqi, Ammad Ahmad ; Blundell, Renald ; Liu, Xiujun ; Lin, Xiukun ; Xu, Yixin ; Zheng, Lanhong ; Zhang, Yan ; Wei, Ning

Protein kinases, mediating their biological function via their catalytic activity, play important role in cell development, including cell proliferation, migration, angiogenesis and survival. Over the years, protein kinase inhibitors have been developed as an important class of anticancer agents clinically. However, the off-targeting and drug resistance of protein kinase inhibitors limit their efficiency. Anticancer peptides derived from marine organisms represent a novel class of bioactive substances, and some of the peptides exhibit anticancer effect via inhibiting protein kinases. In this mini review, the recent progress of anticancer peptides targeting protein kinases from marine sources are presented. Marine peptides inhibiting resistant cancer cells by targeting novel domains of protein kinases are highlighted. The challenges and prospects of developing marine peptides as anticancer agents are also discussed.

12 Nov 2024·Circulation

Abstract 4147387: Outcomes of Heart Failure with Preserved Ejection Fraction with GLP1RA plus SGLT2i vs SGLT2i alone: A Propensity-Matched Nationwide Cohort Study

Author: Anavekar, Nandan ; Alazazzi, Hosam ; Akbar, Absam ; Perez, Jaime Abraham ; Syed, Saif ; Neeland, Ian ; Al-Kindi, Sadeer ; Grace Harper, Elleson ; Deshmukh, Abhishek ; Almas, Talal ; Sullivan, Claire ; Qureshi, Amal

Introduction: Metabolic pharmacotherapies [Glucagon-like peptide-1 receptor agonists (GLP1RA) and sodium-glucose cotransporter type 2 inhibitors (SGLT2i)] have shown benefit in patients with heart failure and preserved ejection fraction (HFpEF). It remains unclear whether the two classes would have additive effects. Methods: We performed a retrospective study using a de-identified federated database with 89 contributing health care organizations (HCO), including over 126 million patients (TriNetX Research Network, Cambridge, MA; date of data access: May 23, 2024). TriNetX regularly aggregates clinical data directly from participating HCOs, and performs extensive data quality and accuracy assessment. While TriNetX obfuscates institutional information relating to participating HCOs, a typical HCO includes a large academic health center with inpatient, outpatient, and specialty care services. We identified all patients with a diagnosis of Heart failure with preserved ejection fraction (HFpEF, ICD-10: I50.3), and SGLT2i usage. We then categorized this patient population into two cohorts, including patients with concomitant GLP1RA use, and patients without GLP1RA use. For both cohorts, we collected data on patient demographics, and the outcomes of all-cause mortality, and all-cause hospitalization, occurring up to 10-years after the index diagnosis. We evaluated differences in outcome risk using hazards ratios and 95% confidence intervals. Results: Prior to propensity score matching, we identified 114,329 patients, with 7931 patients receiving SGLT2i +GLP1RA vs 106398 receiving SGLT2i-alone. Majority (55.7%) identified as white and 24.4% as African Americans and >90% of the patients had a diagnosis of type 2 diabetes mellitus. After propensity matching, the rate of all-cause hospitalization within the combination group was lower than SGLT2i group (29.6% vs 32.4%, HR 0.76 [0.73- 0.79], P<0.001). All-cause mortality for the combination group was 6.8% versus 10.6% within the SGLT2i-alone group (HR 0.52 [0.47-0.56], P<0.001)). Conclusion: In this propensity-matched cohort, patients with HFpEF receiving GLP1RA and SGLT2i had lower rates of hospitalizations and all-cause mortality compared with those receiving SGLT2i alone. Large randomized controlled trials are warranted to corroborate these findings.

100 Deals associated with Rashid Latif Medical College

100 Translational Medicine associated with Rashid Latif Medical College

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 27 Jan 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Rashid Latif Medical College

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 27 Jan 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing