Delving into the Latest Updates on Transilvania University of Brasov with Synapse

Overview

The objective of the HEART Study is to develop a multiscale model of the coronary circulation based on multimodal imaging data (angiography, echocardiography). The predictive comprehensive multi-scale model, developed during this proof-of-concept study, will be used for analyzing functional aspects of coronary artery disease. Model validation is performed against invasive measurements

Start Date01 Aug 2014

Sponsor / Collaborator

Transilvania University of Brasov

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100 Clinical Results associated with Transilvania University of Brasov

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0 Patents (Medical) associated with Transilvania University of Brasov

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7,865

Literatures (Medical) associated with Transilvania University of Brasov

31 Dec 2024·European Journal of Remote Sensing

Images and CNN applications in smart agriculture

Author: Mothe, Josiane ; El Sakka, Mohammad ; Ivanovici, Mihai

01 Dec 2024·Computational and Structural Biotechnology Journal

PS-GO parametric protein search engine

Article

Author: Yallapragada, Venkata V B ; Tabirca, Sabin ; Mi, Yanlin ; Marcu, Stefan-Bogdan

With the explosive growth of protein-related data, we are confronted with a critical scientific inquiry: How can we effectively retrieve, compare, and profoundly comprehend these protein structures to maximize the utilization of such data resources? PS-GO, a parametric protein search engine, has been specifically designed and developed to maximize the utilization of the rapidly growing volume of protein-related data. This innovative tool addresses the critical need for effective retrieval, comparison, and deep understanding of protein structures. By integrating computational biology, bioinformatics, and data science, PS-GO is capable of managing large-scale data and accurately predicting and comparing protein structures and functions. The engine is built upon the concept of parametric protein design, a computer-aided method that adjusts and optimizes protein structures and sequences to achieve desired biological functions and structural stability. PS-GO utilizes key parameters such as amino acid sequence, side chain angle, and solvent accessibility, which have a significant influence on protein structure and function. Additionally, PS-GO leverages computable parameters, derived computationally, which are crucial for understanding and predicting protein behavior. The development of PS-GO underscores the potential of parametric protein design in a variety of applications, including enhancing enzyme activity, improving antibody affinity, and designing novel functional proteins. This advancement not only provides a robust theoretical foundation for the field of protein engineering and biotechnology but also offers practical guidelines for future progress in this domain.

01 Dec 2024·Applied Microbiology and Biotechnology

Mycorrhizal symbiosis and the nitrogen nutrition of forest trees

Review

Author: Pena, Rodica ; Tibbett, Mark

AbstractTerrestrial plants form primarily mutualistic symbiosis with mycorrhizal fungi based on a compatible exchange of solutes between plant and fungal partners. A key attribute of this symbiosis is the acquisition of soil nutrients by the fungus for the benefit of the plant in exchange for a carbon supply to the fungus. The interaction can range from mutualistic to parasitic depending on environmental and physiological contexts. This review considers current knowledge of the functionality of ectomycorrhizal (EM) symbiosis in the mobilisation and acquisition of soil nitrogen (N) in northern hemisphere forest ecosystems, highlighting the functional diversity of the fungi and the variation of symbiotic benefits, including the dynamics of N transfer to the plant. It provides an overview of recent advances in understanding ‘mycorrhizal decomposition’ for N release from organic or mineral-organic forms. Additionally, it emphasises the taxon-specific traits of EM fungi in soil N uptake. While the effects of EM communities on tree N are likely consistent across different communities regardless of species composition, the sink activities of various fungal taxa for tree carbon and N resources drive the dynamic continuum of mutualistic interactions. We posit that ectomycorrhizas contribute in a species-specific but complementary manner to benefit tree N nutrition. Therefore, alterations in diversity may impact fungal-plant resource exchange and, ultimately, the role of ectomycorrhizas in tree N nutrition. Understanding the dynamics of EM functions along the mutualism-parasitism continuum in forest ecosystems is essential for the effective management of ecosystem restoration and resilience amidst climate change.Key points• Mycorrhizal symbiosis spans a continuum from invested to appropriated benefits.• Ectomycorrhizal fungal communities exhibit a high functional diversity.• Tree nitrogen nutrition benefits from the diversity of ectomycorrhizal fungi.Graphical abstract

100 Deals associated with Transilvania University of Brasov

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100 Translational Medicine associated with Transilvania University of Brasov

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