Delving into the Latest Updates on Zhuhai Tengbai Pharmaceutical Co., Ltd. with Synapse

Overview

Basic Info

Introduction

Zhuhai Tengbai Pharmaceutical Co., Ltd. is a manufacturer specializing in the research and development of new anti-cancer drugs. The main biopharmaceuticals developed have the effect of inhibiting angiogenesis activity as well as disrupting integrin functions. They also have inhibitory effects on ion channels and micro-nucleotides, achieving a "multi-target" design with one drug. This allows for a comprehensive and effective suppression of the recurrence and metastasis of various tumors.

Tags

Neoplasms

Digestive System Disorders

Recombinant polypeptide

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2

Top 5 Drug Type	Count

Small molecule drug	1
Recombinant polypeptide	1

Top 5 Target	Count

Integrin	2

主要目的：评价TB01在晚期结直肠癌患者中的抗肿瘤效应。次要目的： 1) 评价 TB01在晚期结直肠癌患者中的药代动力学（ PK）特征 2）评价 TB01在晚期结直肠癌患者中的安全性及耐受性。探索性目的： 1) 探索肿瘤组织中整合素的表达情况与疾病预后的相关性； 2) 探索体内细胞因子及其受体（VEGF、VEGFR）在用药前后的变化及其与疾病预后的相关性； 3) 探索TB01在晚期结肠癌患者中的免疫原性及抗药抗体（ADA）产生对PK、有效性和安全性的影响。

[Translation]

Primary purpose: To evaluate the anti-tumor effect of TB01 in patients with advanced colorectal cancer. Secondary purpose: 1) To evaluate the pharmacokinetic (PK) characteristics of TB01 in patients with advanced colorectal cancer 2) To evaluate the safety and tolerability of TB01 in patients with advanced colorectal cancer. Exploratory purpose: 1) To explore the correlation between the expression of integrins in tumor tissues and disease prognosis; 2) To explore the changes of cytokines and their receptors (VEGF, VEGFR) in the body before and after medication and their correlation with disease prognosis; 3) To explore the immunogenicity of TB01 in patients with advanced colon cancer and the effects of anti-drug antibody (ADA) production on PK, efficacy and safety.

Start Date-

Sponsor / Collaborator

Zhuhai Tengbai Pharmaceutical Co., Ltd.

CTR20213196 / CompletedPhase 1

评估注射用HYD-PEP06在实体瘤患者中安全性、耐受性和药代动力学—一项单中心、单臂、单次及多次给药的I期临床试验

[Translation] Evaluating the safety, tolerability and pharmacokinetics of HYD-PEP06 for injection in patients with solid tumors - a single-center, single-arm, single- and multiple-dose Phase I clinical trial

主要目的评价注射用HYD-PEP06在晚期实体瘤患者中单次给药及多次给药的耐受性和安全性，确定其最大耐受剂量（MTD）和剂量限制性毒性（DLT）。次要目的（1）评价注射用HYD-PEP06在晚期实体瘤患者中的药代动力学特征；（2）初步评估注射用HYD-PEP06治疗晚期实体瘤患者的有效性；探索性目的（1）初步探索注射用HYD-PEP06在人体的免疫原性反应及抗药抗体产生对PK/PD、有效性和安全性的影响；（2）初步探索注射用HYD-PEP06对细胞因子EGF/VEGF的影响。

[Translation]

Main purpose To evaluate the tolerability and safety of single and multiple doses of HYD-PEP06 for injection in patients with advanced solid tumors, and to determine its maximum tolerated dose (MTD) and dose-limiting toxicity (DLT). Secondary purpose (1) To evaluate the pharmacokinetic characteristics of HYD-PEP06 for injection in patients with advanced solid tumors; (2) To preliminarily evaluate the efficacy of HYD-PEP06 for injection in the treatment of patients with advanced solid tumors; Exploratory purpose (1) To preliminarily explore the effects of the immunogenic response and anti-drug antibody production of HYD-PEP06 for injection in humans on PK/PD, efficacy and safety; (2) To preliminarily explore the effects of HYD-PEP06 for injection on cytokines EGF/VEGF.

Start Date03 Apr 2020

Sponsor / Collaborator

Zhuhai Tengbai Pharmaceutical Co., Ltd.

100 Clinical Results associated with Zhuhai Tengbai Pharmaceutical Co., Ltd.

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0 Patents (Medical) associated with Zhuhai Tengbai Pharmaceutical Co., Ltd.

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1

Literatures (Medical) associated with Zhuhai Tengbai Pharmaceutical Co., Ltd.

01 Apr 2023·Acta Pharmaceutica Sinica B

Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria

Article

Author: Li, Xiaokang ; Xu, Yixiang ; Chen, Feng ; Zhang, Chao ; Cheng, Zhiyang ; Zhao, Jinlong ; Zhou, Luoyifan ; Huang, Yunyuan ; Duan, Hao ; Jiang, Kai ; Li, Jian ; Cheng, Jiaxing ; Yang, Xinchun ; Xiang, Yaozu ; Chen, Xin

Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been reapproved for heart failure (HF) therapy in patients with and without diabetes. However, the initial glucose-lowering indication of SGLT2i has impeded their uses in cardiovascular clinical practice. A challenge of SGLT2i then becomes how to separate their anti-HF activity from glucose-lowering side-effect. To address this issue, we conducted structural repurposing of EMPA, a representative SGLT2 inhibitor, to strengthen anti-HF activity and reduce the SGLT2-inhibitory activity according to structural basis of inhibition of SGLT2. Compared to EMPA, the optimal derivative JX01, which was produced by methylation of C2-OH of the glucose ring, exhibited weaker SGLT2-inhibitory activity (IC₅₀ > 100 nmol/L), and lower glycosuria and glucose-lowering side-effect, better NHE1-inhibitory activity and cardioprotective effect in HF mice. Furthermore, JX01 showed good safety profiles in respect of single-dose/repeat-dose toxicity and hERG activity, and good pharmacokinetic properties in both mouse and rat species. Collectively, the present study provided a paradigm of drug repurposing to discover novel anti-HF drugs, and indirectly demonstrated that SGLT2-independent molecular mechanisms play an important role in cardioprotective effects of SGLT2 inhibitors.

100 Deals associated with Zhuhai Tengbai Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with Zhuhai Tengbai Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 26 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

Phase 2 Clinical

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