Evaluation of efficacy in detection of apnoea and airway suctioning using a novel capnosuction mask in adults scheduled for elective surgeries under sedation - An observational feasible study - NIL

Start Date20 May 2025

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Saveetha Engineering College

CTRI/2025/04/084385

/ Not yet recruitingNot Applicable

A comparative study between Application of Absorbable Tacker ABSORBATACK for graft fixation at split skin grafting versus Non absorbable suture for foot ulcer patients - NIL

Start Date01 May 2025

Sponsor / Collaborator

Saveetha Engineering College

100 Clinical Results associated with Saveetha Engineering College

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1,888

Literatures (Medical) associated with Saveetha Engineering College

01 Dec 2025·Recent Patents on Nanotechnology

Investigation of TiO₂ Nanoparticles Influence on Tensile Properties and Thermal Stability of Dry and Wet Luffa-Epoxy Nanocomposites

Article

Author: Hussain, S. Imran ; Anbukarasi, K. ; Senthilkumar, N. ; Kalaiselvam, S. ; Mala, D.

Background:Recently, progress has been made toward understanding the efficiency of polymer composites with natural fibres. With the hope of enhancing the characteristics of polymer composites supplemented with natural fibres in a watery environment, TiO2 nanoparticles have been used to improve their performance in the field.Methods:These nanoparticles were filled in luffa-epoxy components at 1, 3, and 5% volume fractions. A combination of x-ray diffraction and Fourier transform infrared spectroscopy was utilized to conduct the structural examinations. The nanoparticle spread was captured by field emission scanning electron microscopy.Results:Results show that dry nanocomposite's tensile strength and modulus have increased by 74% and, 13%, 137%, and 50% compared with epoxy and 40 vol% luffa-epoxy (E/L) composites, respectively. In wet nanocomposites, maximum reduction in tensile strength and modulus were observed as 27.4% and 16.54%, respectively. The diminished water absorption and thickness swelling percentage of nanocomposites were recorded as 98% and 91.8%, respectively. The onset temperature of these nanocomposites was scattered in the range of 379-393°C, with a maximum char residue of 38%.Conclusion:The increase in the percentage of residue indicates the effectiveness of epoxy's flame retardant, improved thermal stability, diminished water absorption (approximately 2%), and 95% retention of wet composites' tensile properties. These results provided data support for improving the application of nanocomposites in the automobile field and to develop possible patents on the new material development.

01 Oct 2025·Computational Biology and Chemistry

Kolmogorov-Arnold networks for predicting drug-gene associations of HDAC1 inhibitors in periodontitis

Article

Author: Ayyachamy, Swarnambiga ; Yadalam, Pradeep Kumar ; Barbosa, Francisco T ; Natarajan, Prabhu Manickam

Periodontal disease, or periodontitis, is a chronic inflammatory condition affecting the tissues supporting teeth, with epigenetic mechanisms such as DNA methylation, histone modifications, and RNA molecules playing a crucial role in its progression. Histone deacetylase (HDAC) inhibitors have shown potential in treating inflammatory diseases by modulating gene expression to suppress inflammation and promote tissue regeneration. Machine learning models, particularly Kolmogorov-Arnold Networks (KANs), provide an advanced solution for predicting drug-gene associations, offering superior accuracy, efficiency, interpretability, and scalability compared to traditional Multi-Layer Perceptrons (MLPs). This study explores the application of KANs in predicting drug-gene associations of HDAC1 inhibitors for periodontitis. A dataset comprising 533 compounds and genes was analyzed using Cytoscape for network-based topological and functional insights, followed by predictive modeling using KANs. The resulting network contained 326 nodes and 3734 edges, with an average of 23.411 neighbors, a diameter 5, and a characteristic path length of 2.383. The predictive model achieved an impressive accuracy of 96.49 %, as indicated by the F1 score, reflecting balanced performance in classification. The study highlights the potential of KANs in drug discovery for periodontal disease by efficiently predicting drug-gene associations, enabling better understanding and research for experimental validation and clinical applications.

01 Sep 2025·Radiation Physics and Chemistry

Synthesis, structural, and optical properties of lead-free Tm3+ ions doped zinc tellurite glass and Ho3+ ions doped zinc borophosphate glass for radiation shielding application

Author: Vinothkumar, P. ; Jobikha, A. Vincelet ; Yamini, B. ; Praveenkumar, S.

Tm³⁺-doped zinc tellurite (TeBSrZnNaMg: Tm) and Ho³⁺-doped borophosphate (BPAgMgLiZn: Ho) glasses were synthesized via the melt-quenching technique.X-ray diffraction confirmed their amorphous nature.FTIR anal. identified characteristic functional groups.Optical absorption spectra revealed the ³H₆ → ³H₅ transition of Tm³⁺ at 1100-1250 nm, which is significant for IR applications, while the ³H₆ → ³H₄ transition appeared at ∼800 nm.For Ho³⁺ ions, the 5I₈ → 5F₅ transition at 640 nm and 5I₈ → 5I₆ at 1150 nm were observedThe photoluminescence anal. showed emission peaks at 545 nm, 650 nm, and 750 nm for Ho³⁺, with CIE coordinates (x = 0.3215, y = 0.3246) and a CCT of 6057 K.TeBSrZnNaMg: Tm glass exhibited coordinates (x = 0.1684, y = 0.0075) and a CCT of 1916 K.The radiation shielding anal. showed that at 0.015 MeV, the linear attenuation coefficients were 155 cm^-1 (TeBSrZnNaMg: Tm) and 50 cm^-1 (BPAgMgLiZn: Ho), with MAC values of 38 and 13 cm²/g, resp.The HVL was 4.77 cm and 8.173 cm, while TVL was 15 cm and 27.14 cm.FNRCS values were 0.082 cm^-1 and 0.138 cm^-1.The gamma-ray parameters such as Z_eff and mass attenuation coefficients of the fabricated glasses were studied with various energy ranges.A high-purity germanium detector (ORTEC GEM 60P) with an energy resolution of 1.69 keV was used for gamma-ray measurements.JO parameters of both prepared glasses were studied.The results revealed that TeBSrZnNaMg: Tm and BPAgMgLiZn: Ho glasses are appropriate for blocking radiation.

100 Deals associated with Saveetha Engineering College

100 Translational Medicine associated with Saveetha Engineering College

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