Delving into the Latest Updates on Jiangsu Normal University with Synapse

Overview

Tags

Neoplasms

Endocrinology and Metabolic Disease

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	2
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	3

Top 5 Target	Count

MSMP(microseminoprotein, prostate associated)	1

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) has shown a high incidence rate in rice fields in recent years. Rice resistance breeding is considered as the most effective method for achieving economical and sustainable management of BLB disease. The essential basis for resistance breeding is rooted in the exploration of rice resistance genes and the clarification of the molecular mechanisms that underlie Xoo resistance. In our previous research, we showed that Xanthomonas outer protein XopZ and rice oxysterol-binding related protein ORP1C collaboratively regulate the compatible interaction between Xoo strain PXO99 and Nipponbare rice, but the deeper regulatory mechanisms remain unknown. In this study, we successfully constructed ORP1C overexpression rice using the plant binary expression vector pCAMBIA1301. Through a series of virulence and effector translocation detections in Xoo-rice interactions, we revealed that overexpression of the ORP1C gene largely increases rice resistance to multiple Xoo strains from different countries and regions. Mechanistically, ORP1C plays a Xoo resistant role through negatively regulating transcription activator-like effectors (TALEs) translocation, ORP1C has become a potential candidate gene resource for disease-resistant breeding in rice. Further studies also indicated that XopZ and ORP1C collaboratively regulate the compatible interaction of PXO99-Nipponbare by modulating TALEs translocation.

31 Dec 2025·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Permeability Characteristics of Granular Backfill Materials during Creep: a case study

Author: Liu, Yu ; Li, Shuncai

Backfill mining is a lucrative method for extracting coal buried under buildings, and water bodies, which can substantially increase the resource usage efficiency by mitigating the strata movement ...

01 Oct 2025·Talanta

Bipedal DNA walker integrated resonance energy transfer to construct a sensitive electrochemiluminescence biosensor for serotonin detection

Article

Author: Shi, Yibing ; Jiao, Yan ; Feng, Qiumei ; Li, Hongyuan ; Gao, Yongguang

The abnormal level of neurotransmitter serotonin often leads to the blood-brain barrier. Thus, it is urgent to develop a sensitive and efficient method for serotonin detection. Here, we constructed a resonance energy transfer-based electrochemiluminescence (ECL-RET) biosensor sensitized with bipedal DNA walker for the sensitive determination of serotonin. Benefitting from the specific recognition of aptamer to target and enrichment ability of magnetic bead separation, this system achieved the signal transduction of serotonin to nucleic acid and excellent selectivity for serotonin analysis among various analogues. The spectral overlap between the emission spectrum of CdS QDs (energy donor) and the absorption of Ag nanoclusters (Ag NCs, energy acceptor) enabled effective ECL-RET. Through proximity ligation, bipedal DNA walker driven by catalytic hairpin assembly (CHA) significantly accelerated the reaction kinetics and resulted in the amplified responses. Relying on the ECL quenching, serotonin was quantified with a linear detection range of 1 pM-1 μM and a low detection limit of 0.28 pM. More notably, the practical application of the sensor was tested in human serum with recovery rates ranging from 95.0 % to 105.7 %. The combination of ECL-RET, proximity ligation and CHA-driven bipedal DNA walker enabled the biosensor to represent a step forward in neurological-related disease diagnosis.

100 Deals associated with Jiangsu Normal University

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100 Translational Medicine associated with Jiangsu Normal University

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Pipeline

Pipeline Snapshot as of 09 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

3

1

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

TBC-1	Neoplasms More	Discovery
CN118084910	Hypoglycemia More	Discovery
CN118084763 ( MSMP )	Neoplasms More	Discovery
GLP-1/Gastrin Receptor Dual Agonists (Jiangsu Normal University) ( CCKB x GLP-1R )	Obesity More	Pending