Sabinsa Corp.

Oroxylum indicum extract (OIE), prepared from its dried bark, known for neuroprotective and cognitive health support, is evaluated. Oroxylum indicum, the Indian Trumpet Tree, is traditionally known for its numerous medicinal benefits. Almost every part of the plant has been traditionally applied to treat many conditions such as stomachache, rheumatism, jaundice, cough, pharyngitis, acute and chronic bronchitis. Various researchers have demonstrated biological activities including antioxidant, and anti-inflammatory, immunomodulatory, analgesic, anti-cancer, anthelmintic, hepatoprotective, antiulcer, anti-diarrheal, cardioprotective, anti-diabetic, anti-epileptic, wound healing, properties. Since very little scientific evidence was available on safety assessment of OIE, a detailed toxicological evaluation of OIE was executed to ensure its safety for human administration and to harness its potential therapeutic applications. The present study evaluated the acute, subacute, subchronic, and reproductive toxicity of OIE in rodents. Also, the mutagenic potential was evaluated with the bacterial reverse mutation assay and the mammalian bone marrow micronucleus test.No treatment-related study findings were observed, and a No Observed Adverse Effect Level of 400 mg/kg body weight was established in subacute, subchronic, reproductive/developmental toxicity studies. In addition, the findings of genotoxicity as evaluated by in vitro bacterial reverse mutation assay, and in vivo mammalian bone marrow micronucleus test in mice showed that OIE did not induce any mutagenic effects. Henceforth, this toxicological evaluation confirms that oral administration of OIE was found to be safe in rodents, non-mutagenic, without any adverse effects. This study positively impacts in encouraging the use of OIE in various therapeutic applications ensuring its safety.

The beneficial effects of curcumin against various chronic disorders have been shown in the last few decades. However, due to its low bioavailability, therapeutic effects are less than expected. Piperine has been used in scientific evaluations as an effective compound to increase the bioavailability of curcumin. The present review investigated the impact of curcumin plus piperine intake on oxidative stress and inflammatory markers of Randomized Clinical Trials (RCTs).

Using relevant keywords, we searched Cochrane Library, Scopus, PubMed, and Web of Science between January 1st, 1970, and September 30th, 2022. A comprehensive search for RCTs was performed. Continuous data were pooled by Standard Mean Difference (SMD) and 95% confidence interval. All related statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software.

A total of 13 articles were incorporated into the final meta-analysis. According to the current meta-analysis, curcumin plus piperine administration showed a significantly increased SOD activity and GSH levels while significantly decreased MDA concentrations. In addition, our study revealed that curcumin plus piperine significantly decreased TNF-α and IL-6 concentrations.

These results indicated that curcumin plus piperine administration could effectively reduce oxidative stress and inflammation.

Turmerones are major bioactive compounds of Curcuma species with several beneficial pharmacological activities. In addition, various in vivo and in vitro studies noted that turmerones could affect different cytokines, metabolic pathways, and targets. Turmerones will have the potential to be a candidate agent to lessen many pathological and immunological conditions as a result of these pharmacological activities. In this review, we provided information about the pharmacological actions of turmerones using search engines such as PubMed, Google Scholar, Scopus, and Web of Science.