AlphaVax, Inc.

Proven Leader Brings More Than 25 Years of Financial ExperienceDURHAM, N.C., Dec. 04, 2023 (GLOBE NEWSWIRE) -- Chimerix (NASDAQ:CMRX), a biopharmaceutical company whose mission is to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases, today announced the promotion of Michelle LaSpaluto, Vice President of Corporate Financial Planning and Investor Relations, to Chief Financial Officer effective December 1, 2023. “We are excited to announce this well-deserved promotion as Michelle has the proven financial and leadership skills to advance Chimerix into our next growth phase and beyond,” said Mike Andriole, Chief Executive Officer of Chimerix. “Over the last decade, Michelle has grown into a leader within the company having touched every area core to the CFO role, including capital raising, accounting, investor relations, internal controls and supporting business development transactions. Importantly, Michelle’s deep familiarity with our operating structure and programs will enable her quick transition to this expanded responsibility. I look forward to continuing my partnership with her in this new position and am confident in her ongoing success.” “I am honored to step into the CFO role at this point in Chimerix’s growth trajectory. We have an exciting future ahead as we advance our imipridone pipeline and give hope to patients faced with life limiting cancers,” said Ms. LaSpaluto. “We have an exceptional team of talented and dedicated leaders and I look forward to continuing to work together toward building Chimerix into a leading oncology company.” Since joining Chimerix in 2011, Ms. LaSpaluto has served in roles of increasing responsibility spanning finance, accounting, project planning, investor relations and strategy, most recently as Vice President Corporate Financial Planning and Investor Relations. Prior to joining Chimerix, Ms. LaSpaluto was Senior Director of Accounting at AlphaVax. She began her career at Coopers & Lybrand in Detroit before transferring to Raleigh with PriceWaterhouseCoopers. Ms. LaSpaluto holds an M.B.A. from East Carolina University and a B.A. in Accounting from Michigan State University. About Chimerix Chimerix is a biopharmaceutical company with a mission to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases. The Company’s most advanced clinical-stage development program, ONC201, is in development for H3 K27M-mutant glioma. CONTACT: Will O’ConnorStern Investor Relations212-362-1200ir@chimerix.com

DURHAM, N.C., Dec. 04, 2023 (GLOBE NEWSWIRE) -- Chimerix, Inc. (NASDAQ:CMRX), a biopharmaceutical company whose mission is to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases, today announced the promotion of Michelle LaSpaluto, Vice President of Corporate Financial Planning and Investor Relations, to Chief Financial Officer effective December 1, 2023. “We are excited to announce this well-deserved promotion as Michelle has the proven financial and leadership skills to advance Chimerix into our next growth phase and beyond,” said Mike Andriole, Chief Executive Officer of Chimerix. “Over the last decade, Michelle has grown into a leader within the company having touched every area core to the CFO role, including capital raising, accounting, investor relations, internal controls and supporting business development transactions. Importantly, Michelle’s deep familiarity with our operating structure and programs will enable her quick transition to this expanded responsibility. I look forward to continuing my partnership with her in this new position and am confident in her ongoing success.” “I am honored to step into the CFO role at this point in Chimerix’s growth trajectory. We have an exciting future ahead as we advance our imipridone pipeline and give hope to patients faced with life limiting cancers,” said Ms. LaSpaluto. “We have an exceptional team of talented and dedicated leaders and I look forward to continuing to work together toward building Chimerix into a leading oncology company.” Since joining Chimerix in 2011, Ms. LaSpaluto has served in roles of increasing responsibility spanning finance, accounting, project planning, investor relations and strategy, most recently as Vice President Corporate Financial Planning and Investor Relations. Prior to joining Chimerix, Ms. LaSpaluto was Senior Director of Accounting at AlphaVax. She began her career at Coopers & Lybrand in Detroit before transferring to Raleigh with PriceWaterhouseCoopers. Ms. LaSpaluto holds an M.B.A. from East Carolina University and a B.A. in Accounting from Michigan State University. About Chimerix Chimerix is a biopharmaceutical company with a mission to develop medicines that meaningfully improve and extend the lives of patients facing deadly diseases. The Company’s most advanced clinical-stage development program, ONC201, is in development for H3 K27M-mutant glioma. CONTACT: Will O’Connor Stern Investor Relations 212-362-1200 ir@chimerix.com

DUBLIN, March 30, 2023 /PRNewswire/ -- The "Self-amplifying RNA vaccines Patent Landscape Analysis 2023" report has been added to ResearchAndMarkets.com's offering. The pandemic has led to research effort and global coordination, resulting in the rapid development of mRNA vaccines and human clinical trials. Currently, there are 2 main types of mRNA vaccines: conventional non-amplifying mRNA and self-amplifying mRNA (saRNA or replicons). saRNAs are larger than non-amplifying mRNAs and maintain auto-replicative activity derived from an RNA virus vector. saRNA vaccines contain an antigen-encoding sequence and viral RNA polymerase-encoding sequence required for replication. The advantage of the self-replicating approach is that significantly higher amount of antigen can be expressed with lower doses of mRNA, and it achieves longer term expression of the antigen. In addition to clinical benefits such as stronger immune responses, lower vaccine doses and reduced adverse effects, saRNA would have advantages at manufacturing levels. The saRNA vaccine platform may have higher manufacturing productivity and lower cost per dose compared to mRNA vaccines. In human saRNA vaccine, the most advanced application is therapeutic vaccination against cancer or SARS-CoV2, with saRNA encoding tumor antigens (specific or associated) or spike proteins, respectively. Moreover, this innovative and less expensive therapy tends to apply to the veterinary area with treatments for companion animals and livestock. Main other applications of saRNA vaccine are directed against infectious diseases such as influenza, hepatitis and HIV. Currently, there are less than 100 clinical trials in progress, but this number is increasing, reflecting the interest in this topic as well as the economic stakes for companies. However, to date, there is still no product on the EP and US markets, but some patent oppositions have already been initiated against key patents. Thirteen EP opposition proceedings have been identified herein, most of which were filed in the past 5 years and are still pending. With these initial tensions concerning patents and in a swiftly growing technological environment, it is essential to comprehend the Intellectual Property (IP) stance and strategy of these different players. Such insight can help spot business risks and opportunities, foresee forthcoming technologies, and enable strategic decisions to bolster market position. The analysis of the time evolution of patent publications shows that interest in saRNA began in the early 1990s, but it did not gain significant traction. However, in 2012, some scientists seized the first opportunity to encapsulate large saRNAs in lipid nanoparticles (LNP) instead of using viral particles. This was strongly proposed by Novartis researchers who showed that a 9 kb saRNA encapsulated in an LNP elicits broad, potent, and protective immune responses comparable to those of viral delivery technology, but without its inherent limitations. The second decisive event was the use of mRNA in human therapy during the COVID-19 pandemic in 2020, leading to the development of the first mRNA COVID-19 vaccine. These two events allowed saRNA technology to fully develop and led to a significant increase in the number of patent families published in 2021 and 2022, which doubled from 2021 to 2022. Analysis by segment saRNA vaccines have been investigated and the selected patent families labeled according to technologies to which they relate. This IP landscape features the following 2 types of segmentation: therapeutic applications (based on the main object of the invention) and carriers (based on examples describing which delivery systems are used). The therapeutic applications are divided into cancer, SARS-Cov-2, HIV, hepatitis, influenza and veterinary, while the carriers are separated into VRP, LNP, liposome, CNE and polymer. EP oppositions There is a significant number of EP oppositions which reflects the strategic issues of sRNA vaccines for companies. Most of the proceedings are recent, having been filed in the past 5 years, and are still pending. For each opposed patent, the application date, assignee, opponent, opposition year, and results are detailed. Moreover, currently, 225 patents have been granted in the US and Europe. For each of these granted patents, an analysis of the scope of the first claim was carried out manually. This analysis made it possible to identify 44 patents with granted claims providing broad protection to their holders. These patents are detailed in this study (grant date, expected expiration date, and main concepts claimed). Identifying the companies that have recently emerged in the IP landscape Among the players owning patent families related to saRNA vaccines, 21 newcomers were identified. These companies are either start-up firms (8) or established companies (13) developing their first technology in the saRNA field. These technologies are mainly related to SARS-CoV-2 and cancer. Numerous IP newcomers are based in the U.S., while some are based in Europe and Asia. It is possible that one of these innovative companies could become one of the next healthcare unicorns that the big corporations will be tempted to acquire. IP profile of key players This IP study includes a selection and description of main players. The patent portfolio analysis of main players includes a description of the assignee, patent portfolio description, time evolution of patent publication, main geographical coverage and live patents by technical segment. This IP profile overview is followed by the description of the technological content of their key patents and by a table with its clinical trials. Moreover, the report also includes an Excel database with the 392 patent families analyzed in this study. This useful patent database allows for multi-criteria searches and includes patent publication numbers, hyperlinks to the original documents, priority dates, titles, abstracts, patent assignees, each patent's current legal status and segmentation. Key Features PDF>100 slides Excel database containing all patents analyzed in the report, including segmentations and hyperlink to updated online database (legal status, documents etc.) IP trends, including time evolution of published patents, countries of patent filings and patents' legal status Ranking of main patent assignees & analysis of their patented technologies Key players' IP position and relative strength of their patent portfolios Summary of the therapeutic applications: cancer, SARS CoV2, influenza, hepatitis, HIV, veterinary. Summary of the carriers used to saRNA encapsulation: VRP, LNP, liposome, CNE, polymer. Identification of newcomers and start-up firms. Analysis of collaborations and EP patent oppositions. Key patent selection (highly cited & granted patents with broad claims) Key Topics Covered: 1 INTRODUCTION saRNA, a new tool in therapeutic area Scope of the report Reading guide Main patent assignees 2 EXECUTIVE SUMMARY 3 PATENT LANDSCAPE OVERVIEW Time evolution of patent publications Time evolution by country of filing Ranking of most prolific patent applicants Current legal status of the main players Patent legal status of the corpus Mapping of main current IP holders Patenting activity of IP leading companies Time evolution of main patent assignees 4 NEWCOMERS Startup companies Established companies 5 COLLABORATIONS 6 IP POSITION OF MAIN APPLICANTS IP leadership of patent applicants IP prior art blocking potential of patent applicants Strength index of patent portfolios Key patents 7 MAIN EP PATENT OPPOSITIONS 8 GRANTED US & EP PATENTS WITH BROAD CLAIMS 9 PATENT SEGMENTATION Definition Number of patent families by technology Carrier: overview Carrier: key patents Application: cancer Application: SARS CoV2 Application: Influenza Application: Hepatitis Application: HIV Application: veterinary 10 IP PROFILE OF KEY PLAYERS AlphaVax BioNTech Gritstone bio GSK Janssen Merck - Animal Health Novartis 11 METHODOLOGY Patent search, selection and analysis Search strategy Terminologies for patent analysis Strength and blocking potential A selection of companies mentioned in this report includes Alphavax Arcturus Therapeutics Biontech Boehringer Ingelheim - Animal Health CSL - Seqirus Gritstone Bio GSK Janssen Merck Msd Merck Msd - Animal Health Novartis Pfizer Replikun Biotech Sanofi Tengen Biomedical Tiba Biotech Toray Industries For more information about this report visit About ResearchAndMarkets.com ResearchAndMarkets.com is the world's leading source for international market research reports and market data. 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