Jiangsu Feima Pharmaceutical Co., Ltd.

Main purpose: This study used ilaprazole enteric-coated tablets (specification: 5 mg) produced and owned by Jiangsu Pegasus Pharmaceutical Co., Ltd. as the test preparation. According to the relevant regulations of bioequivalence studies, ilaprazole enteric-coated tablets (specification: 5 mg, trade name: Yilian®) owned by Livzon Pharmaceutical Factory of Livzon Group were used as the reference preparation to evaluate the bioequivalence of the test preparation and the reference preparation after administration in the fed state. Secondary purpose: Observe the safety of the test preparation ilaprazole enteric-coated tablets and the reference preparation ilaprazole enteric-coated tablets (Yilian®) in healthy subjects.

Main purpose: This study used ilaprazole enteric-coated tablets (specification: 5 mg) produced and owned by Jiangsu Pegasus Pharmaceutical Co., Ltd. as the test preparation. According to the relevant regulations of bioequivalence studies, ilaprazole enteric-coated tablets (specification: 5 mg, trade name: Yilian®) owned by Livzon Pharmaceutical Factory of Livzon Group were used as the reference preparation to evaluate the bioequivalence of the test preparation and the reference preparation after administration in the fasting state. Secondary purpose: Observe the safety of the test preparation ilaprazole enteric-coated tablets and the reference preparation ilaprazole enteric-coated tablets (Yilian®) in healthy subjects.

This study investigated the pharmacokinetic characteristics of upadacitinib sustained-release tablets (test preparation, strength: 15 mg) provided by Jiangsu Pegasus Pharmaceutical Co., Ltd. and upadacitinib sustained-release tablets (reference preparation, trade name: Rinvoq®, strength: 15 mg) approved by AbbVie Deutschland GmbH & Co. KG in healthy male and female subjects under fasting and postprandial conditions, and evaluated the bioequivalence and safety of the two preparations to provide a basis for the registration application of the test preparation.