Comparative evaluation of a novel oral health tracker cum motivator and conventional oral health education method for improving oral health behavior among 10 to 15 years old school children in Lucknow -A randomized control trial - NIL

Start Date20 Apr 2025

Sponsor / Collaborator

King George's Medical University

CTRI/2024/12/077545

/ Not yet recruitingNot ApplicableIIT

Evaluation of different bedside clinical tests in predicting difficult laryngoscopy and intubation in oral cancer surgery patients- an observational study - NA

Start Date31 Dec 2024

Sponsor / Collaborator

King George's Medical University

CTRI/2024/12/077531

/ Not yet recruitingNot ApplicableIIT

Nutrigenomic Insights into Thalassemia: Resveratrols Influence on HIF-1a and Clock/BMAL1 Genes Expression, Oxidative Stress and bone mineral density (BMD) of North Indian Thalassemia Patients - NIL

Start Date26 Dec 2024

Sponsor / Collaborator

King George's Medical University

100 Clinical Results associated with King George's Medical University

0 Patents (Medical) associated with King George's Medical University

8,279

Literatures (Medical) associated with King George's Medical University

01 Dec 2025·Current Genetics

Metagenomic profiling of plaque microbiota in Indian subjects: identified hidden ecological tapestry

Article

Author: Sandhu, Sangram ; Mohit ; Lal, Nand ; Rai, Niraj ; Jurel, Sunit Kumar ; Singh, Balendra Pratap ; Sharma, Varun ; Kumar, Sachin ; Chand, Pooran ; Singh, Paurabhi

Dental plaque biofilms are the primary etiologic factor for various chronic oral infectious diseases. In recent years, dental plaque shows enormous potential to know about an individual microbiota. Various microbiome studies of oral cavity from different geographical locations reveals abundance of microbial species. Although, the representation of Indian population in this respect is limited, which make us curious to undergo this study. This study investigates the dental plaque microbiota of North Indian individuals based on their age, gender, and dietary patterns; specifically, food preference and availability of water source using 16 S rRNA metagenomics analysis. The findings from this study revealed that Streptococcus levels are high across genders, age groups, and water source, highlighting its role as a predominant dental caries associated species like Streptococcus mutans, Streptococcus pyogenes, Streptococcus sobrinus and Streptococcus oralis in the studied population groups. Additionally, the abundance of Actinomyces is observed higher in young individuals and females whereas Fusobacterium and Leptotrichia were high in elderly individuals. Moreover, non-vegetarians have higher abundance of Streptococcus and Fusobacterium, whereas vegetarians show higher abundance of Prevotella and Leptotrichia. The study also highlights the influence of water type on bacterial composition of dental plaque in the studied population i.e., individuals consuming underground water has high abundance of Streptococcus, whereas individuals consuming RO water exhibit elevated Prevotella and Leptotrichia. Insights emerged from the analysis illuminates the complex dynamics of microbiota in dental plaque among North Indians. This study also highlight that this variation of microbiome is influenced by age, gender, and dietary habits (vegetarian or non-vegetarian lifestyle). These results will fill a significant knowledge gap regarding the Indian dental plaque microbiome but also offer a foundation to conduct metagenome studies and potential therapeutic implications for future personalized oral health interventions.

01 Jul 2025·Free Radical Biology and Medicine

Mitochondrial calcium uniporter regulates human fibroblast-like synoviocytes invasion via altering mitochondrial dynamics and dictates rheumatoid arthritis pathogenesis

Article

Author: Rakshit, Adrija ; Rathore, Manisha ; Lahiri, Amit ; Kumaravelu, Jagavelu ; Shrivastava, Ashutosh ; Guleria, Shivika ; Khan, Shaziya ; Guha, Rajdeep ; Aggarwal, Amita ; Promila, Lakra ; Tomar, Manendra Singh ; Barthwal, Manoj Kumar ; Ammanathan, Veena ; Singh, Nishakumari C ; Sarkar, Kabita ; Mitra, Kalyan

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that currently has no cure. Fibroblast-like synoviocytes (FLS), present in the RA synovium, play a pivotal role in RA pathogenesis. Notably, FLS in the RA patients (RA-FLS) exhibit characteristics similar to cancer cells, like enhanced migration, invasiveness, uncontrolled proliferation, resistance to apoptosis, and metabolic reprogramming. RA-FLS invasiveness is linked to radiographic joint damage in the patients, whereas inhibiting the FLS migration mitigates disease pathology. However, the molecular mechanisms underlying the migration and invasion capabilities of RA-FLS are not entirely understood. In this work, we have explored the function of mitochondrial calcium uniporter (MCU) and calcium signaling in FLS invasion. Our findings demonstrate a positive correlation between MCU expression and RA disease score. Interestingly, mitochondrial size was reduced, and peripheral localization was more pronounced in the RA-FLS when compared to the control FLS. Mitochondrial calcium import inhibition in the FLS by specific MCU inhibitor, Ruthenium-360 restored these altered mitochondrial dynamics and reduced the invasive phenotype. Through unbiased transcriptome analysis, we identified that MCU-mediated calcium signaling in RA-FLS leads to the enriched actin cytoskeleton and focal adhesion pathways responsible for the invasion phenotype, which can be effectively suppressed by inhibiting MCU. Additionally, we found that mitochondrial transport facilitator Miro1 binds to MCU in a calcium-dependent manner and regulates MCU-mediated mitochondrial dynamics and RA-FLS invasion. Experiments utilizing mice xenograft model demonstrated that MCU silencing diminishes the migration of RA-FLS toward the sites of inflammation in the immunocompromised SCID mice. Altogether, our findings highlight MCU as a promising therapeutic target to inhibit RA-FLS migration and RA progression.

01 Jun 2025·Journal of Psychiatric Research

Neuroanatomical landscapes: Delineating the cortical signatures of pediatric major depressive disorder and bipolar disorder

Article

Author: Agarwal, Vivek ; Arya, Amit ; Kumar, Uttam ; Pandey, Himanshu R ; Singh, Anshita

Pediatric mood disorders, including Major Depressive Disorder (MDD) and Bipolar Disorder (BD), exhibit overlapping symptomatology and complex neurodevelopmental trajectories, necessitating a comprehensive investigation of their neuroanatomical underpinnings. This study aimed to characterize structural brain differences in children with MDD and euthymic BD using high-resolution structural magnetic resonance imaging (MRI). A total of 51 children (aged 10-14 years) were categorized into MDD, euthymic BD, and typically developing (TD) controls. Utilizing advanced surface-based morphometry, we examined four cortical features: fractal dimension, gyrification, sulcal depth, and cortical thickness, to delineate disorder-specific and shared neuroanatomical alterations. Additionally, we explored the interaction between white matter volumetrics and these surface-based metrics to assess its modulatory role in structural brain differences. Our results revealed significant cortical alterations, with distinct and overlapping patterns in both MDD and BD. The findings demonstrated disruptions in cortical complexity, folding patterns, and sulcal morphology, particularly in regions implicated in emotion regulation and cognitive processing. These structural variations provide critical insights into the neurodevelopmental alterations associated with pediatric mood disorders. By integrating multiple morphometric parameters, this study offers a comprehensive framework for understanding the neuroanatomical changes in MDD and BD, contributing to more precise diagnostic biomarkers. The results underscore the importance of incorporating surface-based morphometry and white matter interactions in future research to refine early diagnosis and targeted interventions for mood disorders in children.

100 Deals associated with King George's Medical University

100 Translational Medicine associated with King George's Medical University

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