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Last update 23 Jan 2025

Obstetrics and Gynecology Hospital of Fudan University

Education|

1884|

Shanghai Shi, China

www.fckyy.org.cn

Education|

1884|

Shanghai Shi, China

www.fckyy.org.cn

Last update 23 Jan 2025

Overview

Pipeline

Deal

Translational Medicine

Overview

102

Clinical Trials associated with Obstetrics and Gynecology Hospital of Fudan University

ChiCTR2400093812

/ SuspendedNot ApplicableIIT

Aspirin for the prevention of preeclampsia based on platelet aggregation rate - a multi-center, stepped-wedge cluster, randomized controlled trial

Start Date01 Jul 2025

Sponsor / Collaborator

Obstetrics and Gynecology Hospital of Fudan University

ChiCTR2400094745

/ SuspendedEarly Phase 1IIT

Construction and clinical application of a midwife-led continuity of care plan

Start Date01 Feb 2025

Sponsor / Collaborator

Obstetrics and Gynecology Hospital of Fudan University

ChiCTR2500095092

/ SuspendedNot ApplicableIIT

Influence of external cephalic version at different gestational ages on neonatal outcomes- a prospective study

Start Date01 Jan 2025

Sponsor / Collaborator

Obstetrics and Gynecology Hospital of Fudan University

100 Clinical Results associated with Obstetrics and Gynecology Hospital of Fudan University

0 Patents (Medical) associated with Obstetrics and Gynecology Hospital of Fudan University

228

Literatures (Medical) associated with Obstetrics and Gynecology Hospital of Fudan University

31 Dec 2025·Pharmaceutical Biology

Overview of current research on traditional Chinese medicine in skin disease treatment: a bibliometric analysis from 2014 to 2024

Review

Author: Li, Yuan ; Zhang, Lanfang ; Wen, Xue ; Zeng, Ni ; Jiang, Feng ; Cai, Yuan ; Wu, Chuyan ; Sun, Nana ; Bao, Yunlei ; Zheng, Chenjie ; Li, Lin

CONTEXTRecent research has revealed significant advancements in the field of traditional Chinese medicine (TCM) for skin diseases. However, there is a lack of visualization analysis within this research domain.OBJECTIVETo analyze the research directions and advancements in TCM research in skin diseases.MATERIALS AND METHODSPublications related to TCM in skin diseases from 2014 to 2024 were searched on the Web of Science Core Collection (WoSCC), VOSviewer, CiteSpace, and the R package "bibliometrix" were employed to visualize and analyze the retrieved data.RESULTSThe study included 527 articles published in 25 countries. The number of publications consistently increased from 2014 to 2024. The Guangzhou University of Chinese Medicine was the most noteworthy institution in this field. Among the journals in this domain, the Journal of Ethnopharmacology was the most popular, and most frequently co-cited journal. Chuanjian Lu published the most papers and Yin-Ku Lin was the most frequently co-cited author. Among keywords, "psoriasis" appeared the most frequently. Additionally, several emerging research hotspots were identified, indicating the transition from traditional Chinese therapies to investigations of the molecular interactions and network pharmacology of Chinese herbs in treatment of skin diseases over the past decade.DISCUSSION AND CONCLUSIONThis visualization analysis summarizes the research directions and advancements in TCM research on skin diseases. It presents a comprehensive examination of the latest research frontiers and trends and serves as a valuable reference for scholars engaged in the study of TCM research.

01 Jun 2025·IBRO Neuroscience Reports

Postoperative analgesia with morphine promoting microglial activation and neuroinflammation induced by surgery aggravates perioperative neurocognitive dysfunction in aged mice

Review

Author: Zhai, Jingwen ; Shao, Xiuzhi ; Xie, Liping ; Ge, Mingyue

IntroductionPerioperative neurocognitive dysfunction (PND) is a significant challenge for patients who need surgery worldwide. Morphine can trigger an intense inflammatory reaction in the central nervous system (CNS) at the same time as analgesia, thus adverse effects aggravating PND. Microglia polarization is closely involved in the regulation of neuroinflammation and the TLR4/MyD88/NF-κB signaling pathway. However, the mechanisms of morphine analgesia aggravating PND impairment remain unclear.MethodsTibial fracture surgery was performed in 18 months old male C57BL/6 J mice to mimic human orthopedic surgery and postoperative analgesia with morphine hypodermic or ropivacaine. Levels of inflammatory factors in the hippocampus, activation, and phenotype of microglia, an essential protein of TLR4/MyD88/NF-κB signal pathway, synaptic plasticity, and hippocampal-dependent memory function were evaluated after surgery and postoperative analgesia.ResultsMorphine postoperative analgesia increased the expression of pro-inflammatory cytokines IL-1 β, IL-6, and TNF-α, decreased the level of anti-inflammatory IL-10, aggravated the activation of microglia and the destruction of synaptic plasticity in the hippocampus, resulting in hippocampal neuron loss, a significant decrease in the number of synapses and cognitive impairment in aged mice. In addition, the aggravation of neuroinflammatory response and the activation of microglia may be mediated by TLR4/MyD88/NF- κ B signal pathway.ConclusionOur results demonstrate that morphine postoperative analgesia may aggravate microglia activation and neuroinflammation in the hippocampus by regulating the TLR4/MyD88/NF- κ B signal pathway and inhibiting the synaptic plasticity hippocampal neurons. It aggravated the acute cognitive decline and cognitive impairment after tibial fracture in elderly mice.

01 May 2025·Journal of Orthopaedics

The low bone mass density in adults with hypertension: A meta-analysis

Review

Author: Tian, Xiaomei ; Zhang, Liwen ; Gao, Yao ; Yu, Jianli ; Zhang, Guofu

ObjectivesOsteoporosis and hypertension are frequently co-occurring disorders which cause significant challenges to the public health. According to some researches, adult persons with hypertension often have low bone mass density (BMD). However, there are discrepancies in the reported results. Thus, the primary objective of our meta-analysis is to explore the potential link between low BMD and hypertension in adults.MethodsTwo authors systematically carried out a comprehensive review of the available literature on the connection of BMD and hypertension by retrieving PubMed, Web of Science, Cochrane and Embase up to March 2024. The confidence intervals (CIs) and odds ratios (ORs) and were estimated utilising the random effect model. Heterogeneity, subgroup analysis, sensibility analyses and publication bias were performed.Results13 studies from the 6080 unique records were analyzed. Pooled analysis revealed that the danger of low BMD was significantly elevated in hypertensive patients than in non-hypertension (OR 1.33, 95 % CI 1.17-1.53, I ² = 79.9 %, p < 0.01). Subgroup analysis revealed a more pronounced link between low BMD and hypertension in the untreated hypertension group (OR 1.64, 95 % CI 0.45-6.02) as opposed to the cohort receiving antihypertensive medication (OR 1.32, 95 % CI 1.16-1.51). The studies carried out in Europe were consistent with those of studies conducted in Asia and North America.ConclusionsLow BMD is associated with hypertension in adults. Nevertheless, it remains uncertain whether this finding is influenced by shared risk factors, given the considerable heterogeneity between study types and methodologies. Further extensive epidemiological documents are necessary.

100 Deals associated with Obstetrics and Gynecology Hospital of Fudan University

100 Translational Medicine associated with Obstetrics and Gynecology Hospital of Fudan University

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Obstetrics and Gynecology Hospital of Fudan University

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Pipeline Snapshot as of 24 Jan 2025

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