A Three-Arm Randomized Controlled Trial of Once-Weekly and Twice-Weekly Membrane Sweeping from 38 Weeks Versus Routine Management to Promote Vaginal Delivery in Obese Pregnant Women

Start Date15 Jan 2025

Sponsor / Collaborator

Navamindradhiraj University

100 Clinical Results associated with Navamindradhiraj University

0 Patents (Medical) associated with Navamindradhiraj University

906

Literatures (Medical) associated with Navamindradhiraj University

31 Dec 2025·Cogent Education

A comparative study on the effectiveness of interactive versus non-interactive optic disc photograph training modules for glaucoma diagnosis among ophthalmology residents

Author: Ratanawongphaibul, Kitiya ; Kasemsup, Tharnsook ; Pathanapitoon, Kessara ; Manassakorn, Anita ; Tanjirawatana, Thanatcha ; Tantisevi, Visanee ; Rojanapongpun, Prin ; Itthipanichpong, Rath ; Kiddee, Weerawat ; Chansangpetch, Sunee ; Rojananuangnit, Kulawan

01 Jun 2025·Complementary Therapies in Medicine

Pharmacokinetic interactions of fruit juices with antihypertensive drugs in humans: A systematic review and meta-analysis

Review

Author: Jiao, Zheng ; Siritientong, Tippawan ; Leelakanok, Nattawut ; Chareonchokthavee, Wanaporn ; Methaneethorn, Janthima ; Dilokthornsakul, Piyameth

INTRODUCTIONFruit juice-antihypertensive drug interactions can lead to subtherapeutic or supratherapeutic outcomes. This systematic review and meta-analysis assesses such interactions and their potential clinical relevance.METHODSPubMed, Scopus, and Science Direct databases were searched from their inception through June 2024. Eligible studies were those that investigated the effects of fruit juice on the pharmacokinetics of antihypertensive drugs. I² was used to determine heterogeneity among studies, and a random effect model was employed for meta-analysis. This review adhered to PRISMA guidelines and was registered in PROSPERO (CRD42022340159).RESULTSFifty-one studies were included. Most of them were open-label crossover trials. Grapefruit juice (GFJ), an inhibitor of organic-anion-transporting polypeptide (OATP) transporters and cytochrome P450 (CYP) 3A4, significantly decreased the AUC and C_max of aliskiren and celiprolol by approximately 80-90 %. Conversely, the AUC and C_max of calcium channel blockers decreased with variable degrees when co-administered with GFJ. Apple and orange juices have comparable effects on certain medications. Most studies had small sample sizes and were of moderate quality. Hemodynamic effects were not assessed in most studies; thus, the clinical significance of these interactions remains uncertain and should be further investigated.CONCLUSIONCo-administration of fruit juice with antihypertensive drugs can result in an increase or decrease in drugs' bioavailability, depending on the drugs' metabolism route and the involvement of transporters. Though further studies are needed to confirm clinical relevance in hypertensive patients, it is advised to avoid co-consumption of fruit juice with drugs showing significant changes in pharmacokinetic parameters to prevent subtherapeutic or supratherapeutic effects.

01 May 2025·Ophthalmology and Therapy

Minimal Gas Vitrectomy and As-Needed Positioning Duration for Idiopathic Macular Holes

Article

Author: Kritfuangfoo, Thanaporn ; Pokawattana, Itsara ; Tangjitwilaikul, Chosita ; Hemarat, Kornwipa ; Chantarasorn, Yodpong

INTRODUCTIONThis study aimed to investigate postoperative outcomes of minimal gas vitrectomy (MGV) combined with a reduced period of gas-fovea contact in the management of idiopathic full-thickness macular holes (MHs).METHODSThis retrospective cohort study included patients who underwent surgery for MHs with minimal hole diameters of 250-800 µm and categorized them into two groups: conventional fluid-gas exchange (FGX) (38 eyes) and MGV (28 eyes), with FGX replaced by a 1.0-1.2 mL injection of pure sulfur hexafluoride after internal limiting membrane peeling. Postoperatively, patients in the MGV group were kept in a face-down position, switching to face-forward or no positioning (pseudophakia) once MH closure was confirmed by optical coherence tomography, performed every few days during the first postoperative week. The maximum duration of face-down positioning was 5 days.RESULTSMost baseline characteristics were comparable between the two groups except for the proportion of combined cataract surgery and the use of non-expansile gas, which were higher in the FGX group. Prone positioning time in the MGV group was shorter than that in the control group (3.8 days vs. 11.9 days). Subfoveal fluid pocket was present in 73.0% and 5.2% of eyes in the MGV and FGX groups, respectively. Twenty-seven eyes (96.4%) in the MGV group showed MH closure within 3 months. At 12 months, compared to the FGX group, the MGV group exhibited less disruption of the ellipsoidal zone (28.5% vs. 57.8%), superior visual acuity (0.33 ± 0.18 vs. 0.54 ± 0.28), and comparable MH closure rates.CONCLUSIONIn the treatment of medium-sized MHs, when compared to the FGX method, the use of a smaller volume of gas tamponade may be associated with earlier photoreceptor restoration. This method individualized prone positioning period without an immediate impact on central vision post surgery.

100 Deals associated with Navamindradhiraj University

100 Translational Medicine associated with Navamindradhiraj University

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 17 May 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Navamindradhiraj University

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 17 May 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing