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/ Not yet recruitingNot Applicable A multicentre, double-blind, randomised, active- and placebo-controlled clinical trial on the pain relieving effects of the modfied-release formulation of flupirtine in patients suffering from moderate to severe chronic low back pain
Pharmacokinetics, Metabolism and Analgesic Effects of Flupirtine After Intravenous, Single Dose and Chronic Oral Administration in Healthy Subjects Genotyped for NAT2, UGT1A1 and GSTP1
Flupirtine is metabolized in-vitro via carbamate cleavage and N acetylation to glucuronides and mercapturic acid derivatives. The formation of reactive, toxic intermediate products may be influenced by genetic polymorphisms of the involved conjugative metabolic pathways. So the purpose of this study is to measure pharmacokinetics, metabolism and analgesic effects of flupirtine in dependence on the function of NAT2, UGT1A1 and GSTP1.
/ Not yet recruitingNot Applicable A multicentre, double-blind, randomised, placebo-controlled clinical trial to investigate pain relieving effects of the modified release (MR) formulation of flupirtine in patients suffering from moderate to severe chronic low back pain.
100 Clinical Results associated with AWD.pharma GmbH & Co. KG
0 Patents (Medical) associated with AWD.pharma GmbH & Co. KG
01 Nov 2008·MMW Fortschritte der Medizin
AT1-Antagonist bewährt sich auch im Praxisalltag
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Author: Baumhäkel, Magnus ; Müller, Ulrike
01 Jun 2001·Die PharmazieQ4 · MEDICINE
Identität und physikochemische Eigenschaften von 1-(4-Chlorphenyl)-4-morpholino-imidazolin-2-on, AWD 131-138.
Q4 · MEDICINE
Article
Author: Heinecke, K ; Thiel, W
01 Nov 2000·Die Pharmazie
Article
Author: Heinecke, K ; Poppe, H ; Schindler, R ; Szelenyi, I ; Hoefgen, N
100 Deals associated with AWD.pharma GmbH & Co. KG
100 Translational Medicine associated with AWD.pharma GmbH & Co. KG