I-Mab Biopharma Hong Kong Ltd.

NIJMEGEN, Netherlands, Nov. 2, 2022 /PRNewswire/ -- Enzyre, which is developing breakthrough ambulant diagnostic technology for blood coagulation testing, today announced that it has successfully raised EUR 12 million in a Series A financing led by new investor, Oost NL, with participation from i&i Biotech Fund, Demcon Investment as technology partner and existing investors, Takeda Ventures and Novalis Biotech. Part of the funding is an Innovation Credit from the Dutch Government. The proceeds from the financing will enable Enzyre to further develop its unique diagnostic technology platform, EnzyPad, which will enable hemophilia patients to determine and monitor their coagulation status from home in real-time. The funds will support clinical trial registrations, the establishment of a sustainable manufacturing line and investment in expanding applications in the critical care setting. Enzyre's first product, Hemophilia EnzyCard, uses the Company's proprietary EnzyPad platform technology to determine the coagulation status of patients with hemophilia, a rare genetic disorder that is estimated to affect over 800,000 people worldwide.1 Those with hemophilia A lack sufficient blood-clotting factor VIII (FVIII) activity, causing them to bleed for longer after an injury compared to healthy subjects. Due to the complexities associated with managing the condition, patients benefit from being able to safely monitor their condition at home while potentially staying connected with their care team by telemedicine. Enzyre's technology will enable patients to self-test in a home setting, and eventually transfer their coagulation status to their treating physician through a mobile phone app and a cloud-based application. This will allow for timely personalized therapy adjustments that may improve clinical outcomes while avoiding unnecessary travel and hospital exposure, ultimately decreasing overall treatment burden and cost for patients and healthcare systems. Guido Maertens, Chief Executive Officer of Enzyre, said: "We are delighted to have closed this successful financing round which validates our technology and will underpin our ongoing development as we take Enzyre forward into the next phase of growth. We value Takeda's continued support and welcome the commitment from a strong cohort of new and existing investors. Together we look forward to improving the quality of life for patients living with bleeding disorders by driving forward our goal to transform their standard of care." Pieter Rhemrev, senior investment manager at Oost NL, acting as lead investor of the syndicate, commented: "We are excited to be working with Enzyre in developing a truly innovative technology that is a potential game changer in the management of Hemophilia A and other bleeding disorders. Patient outcomes and quality of life will be dramatically improved by the ability of physicians to monitor coagulation status in real-time and we see great potential for the product to enhance personalized care. We look forward to joining this talented team and our syndicate partners in supporting Enzyre's pathway to future success." About Enzyre Enzyre is a spin-out from Radboud University Medical Center in The Netherlands founded by Waander van Heerde and Guido Maertens. The Company aims to develop a diagnostic device to provide patients with the flexibility to assess their coagulation status regardless of where they are. Enzyre's platform requires a small volume of blood to measure up to sixteen reactions simultaneously with high sensitivity and specificity without any laboratory infrastructure, at home, on the road or in a critical care setting. This offers enormous benefits to patients: avoid crisis situations driven by changes in coagulation status, provide ease of mind for patients, empower patients to optimize treatment themselves, be a quick turnaround tool in the clinical setting, reduce GP consultation visits and, as a personalized diagnostic tool, offer great support in a telemedicine setting. For more information, please visit www.enzyre.com About Oost NL Oost NL is the development company of the Eastern Netherlands. It is strengthening the regional economy on behalf of the Ministry of Economic Affairs and Climate Policy and the provinces of Overijssel and Gelderland, by investing public money in entrepreneurs in the east of the Netherlands. In addition to these financial resources, Oost NL also makes its knowledge, expertise and network available. It is active in the top sectors - Food, Energy, Health, Tech and Circular Economy. An optimal balance between social and economic returns is of great importance to Oost NL. It lets entrepreneurs innovate, invest and internationalize to accelerate their growth. In this way it ensures the sustainable growth of the regional economy. In addition, Oost NL creates favourable conditions for solving global, social issues, offering entrepreneurs money and resources to create social returns with a focus on sustainability, smart industry and concepts for a healthy life. For more information, please visit www.oostnl.nl About i&i Biotech Fund (i&i Bio) i&i Bio is a Luxembourg-based venture capital firm that invests in innovative European Life Sciences companies focused on drug discoveries, medical devices, diagnostics, and digital health. The Fund was created thanks to the cooperation of the biotech incubator i&i Prague and the European Investment Fund. With over €45M under management, i&i Bio plans to invest in about 20 early-stage companies. i&i Bio is led by an experienced team of professionals with backgrounds in private equity, healthcare and venture capital supporting entrepreneurs on their journey to global success. Thanks to the close cooperation with the fund's sponsor, the biotech academic incubator i&i Prague, i&i Bio is supporting and advancing transformative Central European technology companies. i&i Bio is supported by an investment from the EIF, with the support of: lnnovFin Equity, with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (EFSI) set up under the Investment Plan for Europe. The purpose of EFSI is to help support financing and implementing productive investments in the European Union and to ensure increased access to financing; and the Pan-European Guarantee Fund (EGF), implemented by the EIF with the financial support of the Participating Member States. The objective of EGF is to respond to the economic impact of the COVID-19 pandemic by ensuring that companies in the Participating Member States have sufficient short-term liquidity available to weather the crisis and are able to continue their growth and development in the medium to long-term. For more information visit www.inibio.eu About Demcon Demcon develops, produces and supplies technology and innovative products. The company was created as a result of the passion of its founders for combining creativity and technical skills focused on solving complex issues. In addition to developing technical solutions, Demcon also focuses its efforts on promoting entrepreneurship and investing in talent and education. For more information, please visit www.demcon.com About Novalis Biotech Novalis Biotech (Ghent, Belgium) is an early-stage venture capital investor in technologies that revolutionize healthcare. The company's core competence lies in digitalization in the life sciences with a focus on bioinformatics, genomics and diagnostics. Novalis strongly believes in applying innovative enabling technology to advance the prevention, diagnosis, or treatment of a disease. For more information, please visit www.noval.is. About Takeda Ventures, Inc. Takeda Ventures, Inc. (TVI) is the corporate venture capital group of Takeda Pharmaceutical Company Limited (Takeda) and was founded in 2001 with the vision of generating disruptive technologies and therapeutic solutions for patients through venture-based partnerships. TVI's mission is to create strategic growth opportunities for Takeda by building, managing and investing in innovation-based companies. TVI partners with academic innovators, entrepreneurs and venture investors to create and nurture a portfolio of companies in an array of therapeutic areas, including oncology, gastroenterology and central nervous system disorders. For more information, please visit www.takedaventures.com

Prague, Czech Republic, September 13th, 2022. CasInvent Pharma, an early-stage drug discovery company developing small-molecule compounds with anticancer properties, has raised a follow-up investment round of €1.3 million provided by KHAN Technology Transfer Fund I (KHAN-I) and i&i Biotech Fund (i&i Bio). With this funding, CasInvent Pharma will be strengthening its portfolio of casein kinase inhibitors and progressing its lead compound to the development candidate status. The company CasInvent Pharma is developing proprietary, highly selective inhibitors of enzymes belonging to the casein kinase 1 (CK1) family, which play an important role in several disease-related processes, including the migration of leukemia cells into lymphoid organs. The small-molecule inhibitors are designed to target individual isoforms of CK1 and thereby selectively eradicate leukemic cells. The CasInvent inhibitors have shown promising effects on hard-to-treat leukemias, suggesting their potential use in diseases that currently have limited treatment options. Overall, approximately 500,000 new cases and more than 300,000 deaths due to leukemia were recorded worldwide in 2020. CasInvent Pharma will also explore the potential of its CK1 inhibitors for the treatment of other cancers, such as solid tumors. “We are confident that through the support of our investors, we will be able to advance our compounds faster into the clinic and to demonstrate the therapeutic anticancer effects of CK1 inhibition in patients. This step will render CasInvent attractive for larger pharma companies, as it will enable them to expand their portfolio with new compounds useful in single-agent as well as combination therapies,” says Vojtěch Helikar, CEO of CasInvent Pharma. “CK1 inhibition provides a novel mechanism of action in different cancer indications, which needs to be exploited in the clinic. We believe that our compounds have the potential to offer novel alternatives of cancer treatment for patients with a high unmet medical need,” adds Alexander Scheer, CSO of CasInvent Pharma. High quality of the research team and the strong support The company CasInvent Pharma was established in 2020 as a spin-off of Masaryk University (MU) in cooperation with the investment partner i&i Prague. “The investment of €1.3 million further confirms the quality of the scientific project that was created and developed for several years at Masaryk University. The establishment of the spin-off company CasInvent Pharma was thus a logical step to advance, and ultimately commercialize, these efforts. I am very pleased that the Technology Transfer Office of MU was part of such an important achievement,” says Radoslav Trautmann, Head of Technology Transfer Department, Masaryk University. “We are looking forward to our first investment in a Czech start-up and our first co-investment with the recently launched i&i Biotech Fund. From the beginning, we were impressed by the high quality of CasInvent's research team and the strong support from Masaryk University and the biotech incubator i&i Prague to make this investment possible. With our deep experience in preclinical development of small molecules, we will be able to make valuable contributions to the design and achievement of the key R&D milestones. We look forward to working with Vojtěch, Alexander and the R&D team,” comment Michael Krebs and Peter Nussbaumer, managing partners of KHAN-I. CasInvent Pharma is i&i Bio’s most recent investment announced this year. It marks yet another successful cooperation with the biotech incubator i&i Prague, one of the main investors of i&i Bio. "We are excited to welcome another promising Czech project to our portfolio. The ability of this spin-off to convince renowned international investors confirms its ambition to be successful on a global scale. It is great to be part of this journey. We are also pleased to use our investment to support research that could help treat serious diseases such as leukemia in the future," says Ivan Vohlmuth, one of the partners of i&i Bio. Contact Martin Kovalčík, + 420 777 472 863, kovalcik@inibio.eu (for i&i Biotech Fund) Vojtěch Helikar, +420 728 995 850, helikar@casinvent.com (for CasInvent) Radoslav Trautmann, +420 605 824 519, trautmann@casinvent.com (for Masaryk University) Anne-Kathrin Klebl, +49 231 97 42 70 29, pr@lead-discovery.de (for KHAN-I) About i&i Bio i&i Bio is a Luxembourg-based venture capital firm that invests in innovative European Life Sciences companies focused on drug discoveries, medical devices, diagnostics, and digital health. The Fund was created thanks to the cooperation of the biotech incubator i&i Prague and the European Investment Fund (see below). With over €45M under management, i&i Bio plans to invest in about 20 early-stage companies. i&i Bio is led by an experienced team of professionals with backgrounds in private equity, healthcare and venture capital supporting entrepreneurs on their journey to global success. Thanks to the close cooperation with the fund’s sponsor, the biotech academic incubator i&i Prague, i&i Bio is supporting and advancing transformative Central European technology companies. For more information visit . About European Investment Fund i&i Bio is supported by an investment from the EIF, with the support of: lnnovFin Equity, with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (EFSI) set up under the Investment Plan for Europe. The purpose of EFSI is to help support financing and implementing productive investments in the European Union and to ensure increased access to financing; and the Pan-European Guarantee Fund (EGF), implemented by the EIF with the financial support of the Participating Member States. The objective of EGF is to respond to the economic impact of the COVID-19 pandemic by ensuring that companies in the Participating Member States have sufficient short-term liquidity available to weather the crisis and are able to continue their growth and development in the medium to long-term. About KHAN-I KHAN Technology Transfer Fund I GmbH & Co KG (KHAN-I) is an early-stage life sciences venture fund with € 70 millions under management. Our mission is to create value through cooperative drug development partnerships with academic innovators in Europe. KHAN-I focuses on first-in-class therapies for attractive markets with a high unmet medical need. The fund is managed by Khanu Management GmbH, an experienced team of professionals with proven track records in early-stage drug development, academic spin-offs as well as pharma licensing and partnering. KHAN-I received an investment from the European Investment Fund (EIF) with support of InnovFin Equity, with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (“EFSI”) under the Investment Plan for Europe. KHAN-I is also supported by Austria Wirtschaftsservice GmbH (AWS with funds provided by the Austrian Federal Ministry for Digital and Economic Affairs and the Austrian Foundation for Research, Technology and Development), Max Planck Foundation and Thyssen’sche Handelsgesellschaft mbH. About Masaryk University Technology Transfer Office Masaryk University Technology Transfer Office is a specialised department of Masaryk University that helps to transfer knowledge and technology into practice. The Office supports the university's cooperation with the commercial sphere, the creation of spin-off companies and the successful commercialisation of university research.

SEOUL, South Korea--(BUSINESS WIRE)-- Genexine (KOSDAQ: 095700) a publicly traded, clinical stage biopharmaceutical company committed to the discovery and development of novel biologics for the treatment of unmet medical needs, today announced that its partner, I-Mab (Nasdaq: IMAB), recently completed patient enrollment in a phase 3 clinical trial of its proprietary long-acting growth hormone, eftansomatropin alfa, also known as GX-H9/TJ101, in China, taking it one step closer to commercialization in a key market. Eftansomatropin alfa (GX-H9/TJ101) was discovered by Genexine and is being co-developed by Genexine and Handok for the potential treatment of pediatric and adult growth hormone deficiency. The phase 3 clinical trial (TALLER) being conducted in China by I-Mab, is a multi-center, randomized, open-label, active-controlled clinical study enrolling 168 patients with pediatric growth hormone deficiency (PGHD). The study is evaluating the efficacy, safety, and pharmacokinetics (PK) of eftansomatropin alfa in PGHD, as compared to Norditropin®, a daily rhGH marketed in China. “This milestone marks a significant step for us in our efforts to commercialize our key products in important unmet medical disorders,” said Neil Warma, President and CEO of Genexine. “GX-H9/TJ101 is one of our important proprietary drug candidates developed from Genexine’s hyFc® platform and is the first product developed from this novel platform to reach phase 3 clinical studies. China represents a critical and significant market for us and we are very pleased with the progress we and our partner I-Mab are making with what we believe is a best-in-class asset with the potential to treat PGHD. We expect to report final data from this phase 3 study in 2023 followed by an expected Biologics License Application (BLA) submission in China.” About Eftansomatropin alfa (GX-H9/TJ101) Eftansomatropin alfa (GX-H9/TJ101) was discovered by Genexine and is being co-developed by Genexine and Handok (KOSPI: 002390) as a differentiated long-acting recombinant human growth hormone. It is being positioned possibly as a more convenient and effective therapy for growth hormone deficiency (GHD). Like endogenous growth hormones, eftansomatropin alfa stimulates the production of insulin-like growth factor 1 (IGF-1) in the liver, which has growth-stimulating effects on a variety of tissues, including osteoblast and chondrocyte activities that stimulate bone growth. IGF-1 is a reliable pharmacodynamic marker and the key mediator of growth-promoting activity of eftansomatropin alfa. Eftansomatropin alfa is based on Genexine's patented hyFc® technology. The hyFc® portion consists of human immunoglobulin D ("IgD") and G4 ("IgG4"). The former contains a flexible hinge, and the latter is responsible for half-life extension through neonatal Fc receptor ("FcRn")-mediated recycling. Eftansomatropin alfa is currently in Phase 3 clinical study in China. It is believed that due to its unique molecular features, eftansomatropin alfa may have advantages over the conventional pegylated rhGH drugs and daily injections. In the previous clinical trials, including a Phase 2 study in Europe, eftansomatropin alfa demonstrated its safety and clinical efficacy of weekly or biweekly regimens as compared to that of the daily injected rhGH (Genotropin®). In October 2015, Genexine licensed the China rights to Tasgen Bio-tech (Tianjin) Co., Ltd. (which was subsequently renamed as I-Mab Bio-tech Tianjin Co., Ltd. and became I-Mab’s subsidiary following an acquisition in 2017). In China, eftansomatropin alfa is also known as TJ101. Genexine retains all rights to the product outside of China in the rest of the world. About Genexine Genexine, Inc. is a publicly traded, clinical-stage biotechnology company focused on the development and commercialization of immunotherapeutics and next-generation long-acting biologics. Its primary technology platforms are Therapeutic DNA vaccine technology and hyFc® fusion technology. The Company has multiple products clinical development including several undergoing Phase 3 registration trials. The Company's proprietary pipeline includes GX-188 for cervical cancer, GX-I7 (efineptakin alfa) for multiple cancers, GX-H9 (eftansomatropin alfa) for Pediatric Growth Hormone Deficiency and GX-E4 for CKD-induced anemia, among others. Genexine has established multiple partnerships with global companies in order to expedite product development and commercialization and create significant value. Genexine is listed on the Korean exchange (KOSDAQ: 095700) and is headquartered in Seoul, Korea. Genexine is committed to the well-being and care of patients worldwide. Forward Looking Statements This press release contains forward-looking statements regarding the business of Genexine, Inc. ("Genexine"). Any statement describing Genexine's goals, expectations, financial or other projections, intentions or beliefs, development plans and the commercial potential of Genexine's drug development pipeline, including without limitation GX-I7 (efineptakin alfa), GX-188E, GX-H9 (eftansomatropin alfa), GX- E4 is a forward-looking statement and should be considered an at-risk statement. Such statements are subject to risks and uncertainties, particularly those challenges inherent in the process of discovering, developing and commercialization of new drug products that are safe and effective for use as human therapeutics, and in the endeavor of building a business around such drugs. Genexine's forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause its results to differ materially from those expressed or implied by such forward-looking statements. Although Genexine's forward-looking statements reflect the good faith judgment of its management, these statements are based only on facts and factors currently known by Genexine. As a result, you are cautioned not to rely on these forward-looking statements. These and other risks concerning Genexine's programs are described in additional detail in Genexine's annual reports on DART (Data Analysis, Retrieval and Transfer System) internet site ( ) of the Korean Financial Services Commission. Genexine assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. View source version on businesswire.com: Contacts For further information, please contact: Mr. Jongsoo Lee Investor Relations, Genexine, Inc. jongsoo.lee@genexine.com Source: Genexine, Inc. View this news release online at: