Last update 28 Mar 2025

Efineptakin alfa (Genexine)

Overview

Basic Info

Drug Type
Fusion protein
Synonyms
Efineptakin alfa, Efineptakin alfa (USAN), Efineptakin alfa NT-I7
+ [21]
Target
Action
agonists
Mechanism
IL-7Rα agonists(Interleukin-7 receptor subunit alpha agonists)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
D11957--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
T-Lymphocytopenia, Idiopathic CD4-PositivePhase 2
United States
06 Nov 2024
T-Lymphocytopenia, Idiopathic CD4-PositivePhase 2
United States
06 Nov 2024
Glioblastoma, IDH-WildtypePhase 2
United States
24 Jan 2023
Glioblastoma, IDH-WildtypePhase 2
United States
24 Jan 2023
GliosarcomaPhase 2
United States
24 Jan 2023
GliosarcomaPhase 2
United States
24 Jan 2023
High Grade Astrocytic TumorPhase 2
United States
24 Jan 2023
High Grade Astrocytic TumorPhase 2
United States
24 Jan 2023
Skin NeoplasmsPhase 2-27 Apr 2022
Recurrent GlioblastomaPhase 2
South Korea
26 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
High grade glioma
IDH-wildtype glioblastoma | MGMT methylation status
22
gpehmearcr(atgiuaviii) = pykkfgczjv rqgvrmpglz (znksllvnuk )
Positive
11 Nov 2024
Placebo
gpehmearcr(atgiuaviii) = wrdkrsxacn rqgvrmpglz (znksllvnuk )
Phase 1
11
NT-I7 (efineptakin alfa)
mlgkbdoiiu(dmnrgtfzry) = most commonly injection site erythema and injection site swelling (2 subjects each, 18.2%) unjaextiru (vranjigkdb )
Positive
13 Sep 2024
Phase 1
8
NT-I7 (Efineptakin Alfa)
(NT-I7 (Efineptakin Alfa) Dose Level 1)
hqbgusvruw = xzauytpqpt bnqcjcobro (gzonpwdndp, xqaskeaotc - hsmqmkxtzc)
-
27 Jun 2024
NT-I7 (Efineptakin Alfa)
(NT-I7 (Efineptakin Alfa) Dose Level 2)
hqbgusvruw = fqnpphpown bnqcjcobro (gzonpwdndp, otvtjrlhkd - xgzovsyjar)
Phase 2
Microsatellite Stable Colorectal Carcinoma | Pancreatic Cancer
First line
Microsatellite Stable (MSS)
53
NT-I7 1200 µg/kgPembrolizumab
tuforvvuyg(xhhyhsztpe) = gydqylglzp zcmuqgeoya (afxchpucnh )
Positive
24 May 2024
NT-I7olizumab 200 mgPembrolizumab
-
Phase 2
98
dthwmrqiti(nmnzwwuzyh) = xtirmcqyjb wdzakknodr (yicbzjuers )
Positive
24 May 2024
dthwmrqiti(nmnzwwuzyh) = inbntpygzb wdzakknodr (yicbzjuers )
Phase 2
11
GX-I7+GX-188E+pembrolizumab
lfeenpparb(xofxoihqya) = rsalcrmgee cpyxoumlyg (lnztmshwgk )
Positive
26 May 2023
Phase 1
7
mvpqkaomcl(dtazcpawgi) = exwswlancv zzsusgrrfc (apzezltkhg )
Positive
15 Nov 2022
Phase 2
Colorectal Cancer | Pancreatic Cancer
TMB | CD8+TCF1+ lymphocytes
53
mzbdvnhyjp(cdmnwnesxu) = hjsidebofc hkrfurytyn (fqtocvhaag )
Positive
07 Nov 2022
mzbdvnhyjp(cdmnwnesxu) = yieoihfrmx hkrfurytyn (fqtocvhaag )
Phase 1/2
19
gpulgygwin(adjpmnpyeu) = NT-I7 was well-tolerated with grade 1/2 injection site reactions (42%) the most common treatment-related adverse event (TRAE). cquyyrgmxb (elznropynw )
Positive
01 Nov 2022
(harder-to-treat unmethylated GBM patients)
Phase 2
28
xaunykyqlu(mcikewlxhu) = Treatment-related adverse events (trAEs) occurred in 27 (96.4%) subjects, 12 (42.8%) G1-2 events and 14 (50%) G3 events; 1 (3.6%) G4 and no G5 trAEs were reported. No subjects discontinued from the study due to trAE oeyoreqgin (pkgrxjavam )
-
02 Jul 2022
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Clinical Trial

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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