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Neoplasms	1
Immune System Diseases	1
Hemic and Lymphatic Diseases	1

Top 5 Drug Type	Count

Small molecule drug	1

Effects of massage (circulation-promoting stimulation) for relief of cold symptoms in women with cold sensitivity -pre and post comparative trial of self-hand massage and ear massage- - Effects of massage (circulation-promoting stimulation) for relief of cold symptoms in women with cold sensitivity -pre and post comparative trial of self-hand massage and ear massage-

Start Date15 Sep 2023

Sponsor / Collaborator

Gunma University School of Medicine

JPRN-UMIN000047331

/ SuspendedNot ApplicableIIT

Shared decision making on dialysis modality selection in Japan: a cross-sectional study - Shared decision making on dialysis modality selection in Japan: a cross-sectional study

Start Date16 May 2022

Sponsor / Collaborator

Gunma University School of Medicine

100 Clinical Results associated with Gunma University School of Medicine

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0 Patents (Medical) associated with Gunma University School of Medicine

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7,494

Literatures (Medical) associated with Gunma University School of Medicine

31 Dec 2025·NMC Case Report Journal

A Primary Spinal Intramedullary Mixed Germ Cell Tumor: A Case Report and Literature Review

Article

Author: TOMOMASA, Ran ; NAKATA, Satoshi ; HONDA, Fumiaki ; HIRATO, Junko ; SHIMAUCHI-OHTAKI, Hiroya ; HORIGUCHI, Keishi ; GOTO, Yuta ; OYA, Soichi ; NAKAMURA, Shunsuke ; YOKOO, Hideaki

Central nervous system germ cell tumors are rare and account for 2% to 3% of all central nervous system tumors in Japan. Here, we report an extremely rare case of a primary spinal intramedullary mixed germ cell tumor. A 33-year-old man presented with a chief report of dysuria and numbness in the right lower extremity. Magnetic resonance imaging revealed a mass lesion on the left side of the intramedullary spinal cord at the Th10-11 vertebral body level with hyperintensity on T2-weighted images, isointensity on T1-weighted images, and uniform contrast in gadolinium. Cerebrospinal fluid examination revealed a few atypical cells. Although tumor removal using the posterior median sulcus approach was attempted, only a biopsy was performed because intraoperative rapid pathology suggested a possible diagnosis of germinoma. Permanent pathology revealed a mixed germ cell tumor (mainly comprising a germinoma with a yolk sac tumor). Postoperatively, cerebrospinal irradiation and 8 courses of the carboplatin and etoposide regimen were administered. No recurrence or new lesions were observed on magnetic resonance imaging at 94 months postoperatively. Our extensive literature search found only 4 cases of a mixed germ cell tumor of primary intramedullary origin in the spinal cord. Most spinal germ cell tumors described in the literature are either germinomas or mature teratomas; however, mixed germ cell tumors can also occur, albeit infrequently. Although additional cases need to be accumulated, our case suggests that yolk sac elements in spinal mixed germ cell tumors might not be directly associated with poor life expectancy.

01 Dec 2025·Histochemistry and Cell Biology

A simple immunohistochemical method for perinatal mammalian ovaries revealed different kinetics of oocyte apoptosis caused by DNA damage and asynapsis

Article

Author: Kogo, Hiroshi ; Yamamoto, Hanako ; Ikezawa, Maiko ; Matsuzaki, Toshiyuki ; Iizuka-Kogo, Akiko ; Tajika, Yukiko

Oocytes with meiotic defects are assumed to be eliminated by apoptosis in the perinatal period. However, oocyte apoptosis caused by meiotic defects has not been well analyzed, partly because of the great technical demands of tissue sectioning perinatal ovaries. In the present study, we applied a squash method for immunohistochemical analysis of perinatal mouse ovaries as a substitute for tissue sectioning. As a result, we could show different kinetics of apoptosis caused by DMC1- and SPO11-deficiencies, indicating that DNA damage-induced apoptosis precedes asynapsis-induced apoptosis in mouse oocytes. Double-mutant analysis revealed that only asynapsis-induced apoptosis was significantly dependent on HORMAD2. The present method is simple, easy, and able to analyze a sufficient number of oocytes to detect infrequent events in a single specimen, accelerating detailed immunohistochemical analyses of mammalian ovaries during the fetal and perinatal periods.

01 Dec 2025·Cancer Chemotherapy and Pharmacology

Variations in serum concentrations of sunitinib and its metabolites in patients receiving long-term sunitinib treatment

Article

Author: Yamamoto, Koujirou ; Kogo, Mari ; Morita, Jun ; Sato, Miki Takenaka ; Fukagai, Takashi ; Araki, Takuya ; Yashima, Hideaki ; Maeda, Yoshiko ; Ohbayashi, Masayuki ; Kohyama, Noriko ; Ishikawa, Yuya ; Ogawa, Yoshio

PURPOSEThe blood concentrations of some tyrosine kinase inhibitors are known to decrease with long-term administration. We evaluated the variability in the serum concentrations of sunitinib and its metabolites in patients receiving long-term sunitinib treatment.METHODSThis study prospectively recruited patients who received sunitinib for metastatic renal cell carcinoma at the Showa University Hospital between March 2020 and January 2022. Bivariate correlations between the serum concentration/dose (C/D) ratios of sunitinib and its metabolites (i.e., N-desethyl sunitinib and sunitinib N-oxide) and treatment duration were evaluated using Pearson's correlation coefficient.RESULTSSeven patients were enrolled, and 79 blood samples were collected. Among six patients who received sunitinib for > 1 year, three showed a decreasing trend in the C/D ratio of sunitinib (Pt1: r = -0.608, p = 0.047; Pt2: r = -0.555, p = 0.077; Pt6: r = -0.590, p = 0.073). In these patients, the median annual decrease in the C/D ratio of sunitinib was 55.8% (26.5-63.2%). Additionally, two of the three patients also showed a decrease in the C/D ratio of N-desethyl sunitinib. The ratio of N-desethyl sunitinib/sunitinib concentration at baseline and the end of follow-up was similar between the C/D-decreased and C/D-non-decreased groups.CONCLUSIONThis study showed that the C/D ratio of sunitinib decreased by half over time in half of the patients who received long-term sunitinib treatment despite continuing the same dose. Therefore, serum concentrations of sunitinib and its metabolites should be monitored periodically in patients receiving long-term treatment to prevent decrease in serum sunitinib concentrations.

100 Deals associated with Gunma University School of Medicine

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100 Translational Medicine associated with Gunma University School of Medicine

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Pipeline

Pipeline Snapshot as of 30 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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