Delving into the Latest Updates on Affiliated Hospital of Jiangnan University with Synapse

Overview

Tags

Neoplasms

Urogenital Diseases

Immune System Diseases

Diagnostic radiopharmaceuticals

Radionuclide Drug Conjugates (RDC)

Radiopharmaceuticals and diagnostic agent

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	8
Endocrinology and Metabolic Disease	1
Hemic and Lymphatic Diseases	1
Immune System Diseases	1

Top 5 Drug Type	Count

Diagnostic radiopharmaceuticals	5
Radionuclide Drug Conjugates (RDC)	3
Radiopharmaceuticals and diagnostic agent	2
Therapeutic radiopharmaceuticals	1
Radiolabeled antibody	1

Top 5 Target	Count

PSMA(Prostate-specific membrane antigen)	2
EDB-FN(Human fibronectin extra domain B)	1

PURPOSEThis study aimed to investigate the inhibitory effect of chrysophanol on renal fibrosis and its molecular mechanism.METHODSInitially, potential targets of chrysophanol were predicted through network pharmacology analysis, and a protein-protein interaction network of these targets was constructed using Venn diagrams and the STRING database. GO enrichment analysis predicted the biological process of chrysophanol in treating renal fibrosis. Subsequently, both in vivo and in vitro experiments were conducted using unilateral ureteral obstruction (UUO) induced CKD mouse model and HK-2 cell model, respectively. In the mouse model, different doses of chrysophanol were administered to assess its renal protective effects through biochemical indicators, histological examination, and immunofluorescence staining. In the cell model, the regulatory effect of chrysophanol on the Trx-1/JNK/Cx43 pathway was evaluated using western blotting and flow cytometry.RESULTSChrysophanol treatment significantly ameliorated renal dysfunction and histopathological damage in the UUO mouse model, accompanied by a reduction in serum oxidative stress markers. Furthermore, chrysophanol markedly upregulated the expression of Trx-1 in renal tissues and inhibited the activation of the JNK/Cx43 signaling pathway. At the cellular level, chrysophanol enhanced the activity of Trx-1 and downregulated the JNK/Cx43 signaling pathway, thereby inhibiting TGF-β induced oxidative stress and cell apoptosis.CONCLUSIONThis study demonstrated a significant inhibitory effect of chrysophanol on renal fibrosis, mediated by the activation of Trx-1 to inhibit the JNK/Cx43 pathway. These findings provide experimental support for the potential use of chrysophanol as a therapeutic agent for renal fibrosis.

01 Dec 2024·Cellular Signalling

The promotion of cell proliferation and invasion in cutaneous squamous cell carcinomas after ARNT downregulation is associated with CXCL3

Article

Author: Hu, Ting-Ting ; Pan, Zhan-Yan ; Dong, Da-Ke ; Mo, Xiao-Hui ; Shi, Zhi-Nan ; Ju, Qiang ; Yuan, Hui-Jie ; Wu, Qiong

The aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor associated with adaptive responses to cellular stress. Its role in cutaneous squamous cell carcinoma (cSCC) remains poorly understood. The aim of this study was to investigate the role of ARNT in cSCC. Immunohistochemistry revealed downregulation of ARNT in cSCC, precancerous lesions (actinic keratosis), and cells. Knockdown of ARNT in A431 and SCL-1 cells significantly enhanced cell growth and metastasis. Microarray analysis and Ingenuity Pathway Analysis confirmed that loss of ARNT in A431 cells was highly correlated with cell growth and movement and upregulated CXCL3 expression. Cellular and xenograft experiments further confirmed that ARNT regulates cSCC proliferation and invasiveness in a CXCL3-dependent manner. ARNT may regulate CXCL3 expression through ROS-STAT3 pathway. In conclusion, this study demonstrates that ARNT plays a critical role in the development of cSCC and significantly affects the proliferation and metastatic ability of cSCC cells. It has the potential to serve as an ideal treatment target for cSCC.

01 Dec 2024·Molecular and Biochemical Parasitology

MicroRNAs in opisthorchiids and their definitive hosts: Current Status and Perspectives

Review

Author: Ding, Jian ; Han, Su ; Jiang, Xu ; Zhang, Yu ; Sun, Yifan ; Cao, Jianping ; Cheng, Yang ; Li, Xiang ; Wan, Jie ; Zhang, Xiaoli ; Zhang, Xueli ; Chen, Rui

Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose serious threats to humans in certain countries and cause opisthorchiasis/clonorchiasis. Opisthorchiid flukes parasitize the biliary tract of the host, causing cholangitis, cholecystitis, cholelithiasis and cholangiocarcinoma. In this review, we primarily focus on recent microRNAs (miRNAs) studies of opisthorchiid flukes and their definitive hosts. Many miRNAs are conserved and expressed in a developmentally stage specific manner in the three opisthorchiid flukes, which play important roles in the growth and development of Opisthorchiidae spp., as well as host-pathogen interactions. Some miRNAs might be potential biomarkers related to carcinogenesis of cholangiocarcinoma. Therefore, this review provides the basis for further investigating the roles of miRNAs in opisthorchiid flukes and their definitive hosts, as well as promoting the development of novel approaches to prevent and treat opisthorchiasis/clonorchiasis.

100 Deals associated with Affiliated Hospital of Jiangnan University

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100 Translational Medicine associated with Affiliated Hospital of Jiangnan University

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Phase 1 Clinical

8

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

NY-008((Norroy Bioscience)	Multiple Myeloma More	Phase 1 Clinical
68Ga-NY105	Neoplasms More	Phase 1 Clinical
68Ga-NY104	Renal Cell Carcinoma More	Phase 1 Clinical
NY-009	Neoplasms More	Phase 1 Clinical
177Lu-B5-IgG4(Affiliated Hospital of Jiangnan University) ( EDB-FN )	Solid tumor More	Phase 1 Clinical