ARG2

In H1 2024, Molecure focused on the development of two key molecules: OATD-01 and OATD-02, as well as expanding research activities based on, among other things, advanced artificial intelligence technologies In May, Molecure received approval to initiate a Phase II clinical trial (KITE) for clinical candidate OATD-01 for the treatment of pulmonary sarcoidosis in the European Union and Norway. Earlier, Molecure received approval from the U.S. FDA and the U.K. MHRA In the OATD-01 clinical trial, the Company currently has 13 sites activated in the US, the European Union, the UK and Norway. More will be activated by mid-November this year. Progress in the Phase I clinical trial of OATD-02, the first-in-class dual arginase inhibitor being developed for the treatment of cancer. Following analysis of clinical and pharmacokinetic data and Safety Review Committee (SRC) recommendations, recruitment continues with the addition of 3 additional patients in the fourth cohort at the 20 mg dose level, with the goal of expanding the amount and scope of data to inform decisions on further dose escalation Molecure has confirmed in in vitro tests the ability of the second molecule already being developed within the mRNA platform to effectively bind to the presumed mRNA fragment and block the translation process of the pathogenic protein. Reaching the PoC (in vitro proof-of-concept) stage for yet another molecule being developed in the mRNA platform is evidence of the effectiveness of Molecure’s strategy to identify mRNA-binding compounds with therapeutic potential. In July, Molecure and Avicenna Biosciences entered into a strategic research collaboration agreement to optimize USP7’s small-molecule drug discovery and development processes. The collaboration will combine Molecure’s extensive drug discovery and USP7 biology expertise with Avicenna’s machine learning-based medicinal chemistry platform to identify new drug candidates with superior pharmaceutical properties. In August, Dr Piotr Iwanowski, M.D., was appointed Chief Medical Officer (CMO) and Member of the Management Board of Molecure S.A., he will assume the above functions on September 30th this year. Warsaw, 27 September 2024 – Molecure S.A. (“Molecure”, WSE ticker: MOC), a biotechnology company that discovers and develops drugs to the clinical stage and leverages its globally unique expertise in medicinal chemistry and biology to explore and develop first-in-class small-molecule drugs that directly modulate protein activity and mRNA function to treat a wide range of incurable diseases, has released its report for the first half of 2024. The report is available at: https://molecure.com/pl/informacje-dla-inwestorow/ Marcin Szumowski, CEO Molecure S.A. „In the past six months, our main focus has been on the continued clinical development of OATD-01 and OATD-02. We continued to recruit to clinical trial of OATD-01, a first-in-class chitotriosidase 1 (CHIT1) inhibitor, in patients with pulmonary sarcoidosis on both continents. A positive decision by regulatory authorities from European countries, following earlier approval in the US and UK, has given us the “green light” to conduct Phase II trials of OATD-01 also in Denmark, France, Greece, Germany and Norway. We still hope that we will be able to involve Polish centers and Polish patients in this study. We are planning the first readouts of intermediate signals of therapeutic efficacy and safety in patients with sarcoidosis at the first half of 2025. However, due to the double-blinding requirement of the study, the publication of the final results will occur after the completion of the study and is scheduled for 2026. Our attention in the OATD-01 program is increasingly focused on the area of metabolic diseases, particularly MASH (metabolic dysfunction-associated steatohepatitis). We have very good preclinical results and there are a growing number of scientific publications from genetic studies and based on samples from MASH patients highlighting the key role of CHIT1 in disease escalation. The MASH market is projected to grow at more than 40% CAGR annually to a size of more than $25 billion in 2032. Molecure aims to play a significant role in treatment in MASH in partnership with a major company in the area of progressive metabolic liver disease. Scientific data and market projections support our assumptions about the therapeutic potential of blocking chitinases in multi-organ diseases. In the Phase I clinical trial of OATD-02, an innovative arginase inhibitor, we are continuing to recruit and add 3 more patients to this cohort after analyzing data from the fourth cohort at the 20 mg daily dose level and the Safety Review Committee’s recommendation. As recommended by the SRC, we want to collect more extensive pharmacokinetics and pharmacodynamics data at this stage in order to decide whether to further increase the dose. We are confident that this next phase will bring us significantly closer to bringing breakthrough therapies to market that can change the lives of patients around the world. We see great potential for a platform of small-molecule drug discovery that modulates mRNA function. In December 2023, we obtained positive in vitro results for the first of our molecules, and just a few months later we confirmed translation inhibition for another molecule targeting a different mRNA target. At the BIO International Convention in San Diego in early June, we had many meetings with representatives of Big Pharma companies interested in collaborating on the mRNA platform. In small molecule technology targeting mRNA, we are at the European and even global forefront, so we assume that establishing a commercially attractive collaboration with a large industry partner is likely within the next year. Also noteworthy is the establishment of a strategic collaboration with Avicenna Biosciences to support the discovery and development of new small-molecule drugs targeting ubiquitin-specific protease 7 (USP7), a deubiquitinating enzyme that promotes oncogenesis and whose high expression is observed in a number of cancers. By combining Molecure’s expertise on this attractive, in vivo validated target with Avicenna’s machine learning-driven medicinal chemistry platform, we intend to generate better drug candidates with optimal pharmacological profiles for further preclinical and clinical development.” Webinar with Molecure’s Management Board A meeting will be held on October 1, 2024 at 2:00 pm to discuss the Company’s operational and financial situation for 1H 2024, including the presentation of progress in ongoing research programs, as well as development plans for the coming quarters. The meeting will be held in online format, at the link: Original path – Polish:https://livingmedia.com.pl/live/molecure/1H2024-pl English: https://livingmedia.com.pl/live/molecure/1H2024-en Business Development activities In the first half of 2024, representatives of the Company participated in two important industry conferences: BIO Europe Spring in Barcelona, where they held 38 meetings with biotech and pharmaceutical industry representatives, mainly potential partners, investors and global pharmaceutical companies. The key topics of discussion were OATD-01 (more than 50% of the meetings), OATD-02 and the RNA platform, BIO International Convention in San Diego, where they held a total of a record 42 meetings, of which as many as 28 were related to OATD-01, demonstrating the growing and increasingly concrete interest in the results of preclinical and clinical research in lung diseases and also in metabolic diseases such as MASH. In addition, representatives of the Company participated in conferences: “Immunometabolism in Health and Disease” organized by Gordon Research Conferences at the American Bryant University in Smithfield, congress The European Congress of Life Sciences EUROBIOTECH in Krakow, Poland, International Conference on Medicinal Chemistry in Bordeaux, France, PHASE2024 in Warsaw, Americas Association of Sarcoidosis and Other Granulomatous Disorders (AASOG) in Baltimore, USA, IPF Summit in Boston, USA, and many others.. The company will participate in more industry conferences this year, including but not limited to major global events i.e. Bio Europe in Stockholm, as well as WASOG in India. Summary of financial data in 1H 2024* Operating income of PLN 0.4 million, up from PLN 1.8 million in 1H 2023. Operating expenses amounted to PLN 15.6 million, compared to PLN 17.2 million in 1Q 2023. 1H 2024 saw a decrease of PLN 1.6 million in operating expenses compared to 1H 2023. The main factor for the change was a decrease of PLN 0.5 million in program expenses, which, in accordance with the new accounting policy, are no longer capitalized under uncompleted development work. In addition, costs of legal and consulting services decreased by about PLN 0.9 million in 2024 compared to 2023. Net loss amounted to PLN 14.6 million compared to PLN 12.9 million in the same period in 2023. As of June 30, 2024, Molecure had cash of more than PLN 38 million, and the end of September this year. PLN 27 million. In addition, contracted grant funding for the coming years amounts to PLN 32.5 million. The company plans to raise further project grants as part of its expanding pipeline of clinical and preclinical projects. * Comparative figures for the first half of 2024 have been restated for comparability due to a change in accounting policy. *** About Molecure S.A. Molecure S.A. is a biotechnology company that discovers and develops drugs to the clinical stage, leveraging its own unique expertise in medicinal chemistry and biology to explore and develop first-in-class small-molecule drugs that, through direct modulation of previously unexplored protein and RNA targets, could provide therapies for many incurable diseases. Molecure has generated a diverse portfolio of seven distinct programs with the support of leading academic research institutions around the world, including Yale University, Rutgers University, the Flemish Institute for Biotechnology (VIB) in Ghent, the University of Michigan and the International Institute of Molecular and Cell Biology in Warsaw, Poland (MIBMiK). The most advanced drug candidate developed by Molecure is OATD-01, a first-in-class CHIT1 inhibitor for the treatment of interstitial lung diseases such as sarcoidosis and idiopathic pulmonary fibrosis, and MASH, which is in phase II clinical trials. The second drug candidate is OATD-02, an oral, selective, first-in-class, dual arginase inhibitor (ARG1 and ARG2) for the treatment of cancer, whose Phase I clinical trial has begun with first patient administration in Q1 2023. Molecure’s headquarters and laboratories are located in Warsaw and Lodz. The company is listed on the Warsaw Stock Exchange (ticker: MOC). For more detailed information, please visit: https://molecure.com/pl/ LinkedIn: Molecure | Twitter: @molecure_sa | YouTube: Molecure SA

Warsaw, Poland and Durham, North Carolina, USA, July 31, 2024 – Molecure S.A. (‘Molecure’, SWE Ticker: MOC) and Avicenna Biosciences, Inc. announced today that they have entered into a strategic research collaboration to facilitate the discovery and development of novel small molecule drugs targeting ubiquitin-specific protease 7 (USP7), a deubiquitinase relevant in a number of tumors. The collaboration will combine the extensive expertise of Molecure related to drug discovery and biology of USP7 with Avicenna’s machine learning-driven medicinal chemistry platform to identify novel drug candidates with superior pharmaceutical properties. USP7 is an attractive target in cancer which regulates the stability of crucial proteins involved in pathways relevant for tumor suppression and immune response. Under the terms of the agreement, Avicenna will design algorithms to identify new chemical entities which inhibit USP7, and meet pre-specified pharmacological criteria. Molecure will be responsible for synthesizing and evaluating these new chemical entities and selecting one or more for further development. Molecure retains the right to develop and commercialize novel drug candidates resulting from the collaboration. Avicenna, under the risk-sharing model, will receive an upfront fee and research funding, which will be contingent upon the generated compounds meeting the established success criteria. Additionally, if Molecure exercises the option to license the generated molecules, Avicenna will be eligible for license fees and will retain a specified share in the future revenues derived from drug candidates developed by Molecure. Marcin Szumowski, Molecure’s CEO said: “By combining Molecure’s in-depth knowledge of this attractive, validated in vivo target with Avicenna’s ML-driven medicinal chemistry platform, we intend to generate superior drug candidates with optimal pharmacological profiles for further preclinical and clinical development.” Chris Meldrum, President & CEO of Avicenna, stated: “We have been very impressed with the Molecure team, their deep expertise in targeting USP7, and their efforts to deliver new treatment options to patients with difficult-to-treat cancers. Avicenna welcomes the challenge to transform chemical potential to biological and clinical reality for this important target.” *** About Molecure S.A. Molecure S.A. is a biotechnology company that discovers and develops drugs to the clinical stage, leveraging its own unique expertise in medicinal chemistry and biology to search for and develop first-in-class small-molecule drugs that, through direct modulation of previously unexplored protein and RNA targets, may provide therapies for many incurable diseases. Molecure has generated a diverse portfolio of seven distinct programs with support from leading academic research institutions around the world, including Yale University, Rutgers University, the Flemish Institute for Biotechnology (VIB) in Ghent, the University of Michigan and the International Institute of Molecular and Cell Biology in Warsaw, Poland (MIBMiK). The most advanced drug candidate developed by Molecure is OATD-01, a first-in-class CHIT1 inhibitor for the treatment of interstitial lung diseases such as sarcoidosis, idiopathic pulmonary fibrosis and MASH. The second drug candidate is OATD-02, an oral, selective, first-in-class, dual arginase inhibitor (ARG1 and ARG2) for the treatment of cancer, whose Phase I clinical trial has begun with first patient administration in Q1 2023. Molecure’s headquarters and laboratories are located in Warsaw and Lodz. The company is listed on the Warsaw Stock Exchange (ticker: MOC). Detailed information can be found at: https://molecure.com/pl/ LinkedIn: Molecure | Twitter: @molecure_sa | YouTube: Molecure SA About Avicenna Biosciences Avicenna was founded in 2020 by Drs. Thomas Kaiser and Pieter Burger out of the Liotta Research Group at Emory University. The company is on a mission to solve the intractable drug design challenges that previously stopped drug candidates in their tracks. Its machine learning-driven medicinal chemistry platform makes lead-to-drug optimization faster, cheaper and more successful – transforming sub-optimal clinical candidates into life-saving drugs. Avicenna is backed by DCVC Bio. The company’s peer-reviewed research has been published in outlets such as Journal of Chemical Information and Modeling. For more information, visit www.avicenna-bio.com and follow the company on LinkedIn. Avicenna Media Contact Kerry Walker kerry@walkercomms.com

– In December 2023, Molecure confirmed the inhibition of protein translation with compounds targeting the mRNA in an in vitro proof-of-concept (PoC) using a cell-based assay – This month, Molecure confirmed inhibition of the protein translation function for another mRNA target. Another small molecule discovered and synthesized by Molecure showed efficacy in an in vitro assay, expanding the number of selective binders in its mRNA discovery platform. – The achievement of the PoC stage for another molecule and a second target in the mRNA platform provides evidence of the effectiveness of Molecure’s strategy to identify mRNA-binding compounds with therapeutic potential – Strong biopharmaceutical industry interest in Molecure’s mRNA targeting technology increases the commercial potential of Molecure’s mRNA discovery platform and the likelihood of signing a collaboration or partnership agreement. Warsaw, 12th June 2024 – Molecure S.A. (‘Molecure’, WSE ticker: MOC), a biotechnology company discovering and developing drugs to the clinical stage that leverages its globally unique expertise in medicinal chemistry and biology to search for and develop first-in-class small-molecule drugs that directly modulate protein activity and mRNA translation for the treatment of multiple incurable diseases, has confirmed in vitro the ability to bind to another mRNA target and demonstrated efficacy of a second molecule in inhibiting the translation mechanism of a pathological protein using compounds that target the mRNA encoding that protein. This is another success in the development of the mRNA discovery platform and one of the Company’s strategic goals for 2023-2025. „The discovery of another class of molecules binding to a second mRNA biological target, confirmed in in vitro assays, is the result of our team’s tremendous commitment and innovative approach to finding new molecules that modulate the translational function of mRNA. In December 2023, we obtained positive in vitro results for the first class of our molecules, and just a few months later we confirmed translational inhibition for another molecule targeting a different mRNA target. This attests to the broad scientific competence of our team and the high quality of our drug design processes, which we are improving through the use of advanced AI tools and computational methods. In the mRNA-targeting small molecule technology, we are in the European and even global vanguard and see great commercial potential for our mRNA discovery platform. At the June BIO International Convention in San Diego, we had many meetings with representatives of companies interested in collaborating on discovering and developing small molecules targeting mRNA. Most of them were BigPharma representatives. We see many large partnership deals in this space signed at very early stages of drug development. In line with our strategy, this should allow us to intensify our partnering discussions and increase the likelihood of establishing a commercially attractive collaboration with a large industry partner. We are very pleased with multiple discussions we had during the recent BIO in the US with potential partners regarding our research program pipeline” – said dr Zbigniew Zasłona, CSO Molecure S.A. Molecure in the area of the mRNA platform is considering several commercialisation models, including a service model based on generating revenue from collaborating on the development of mRNA targets selected by the partner, which, through the use of a platform supported by AI tools, the Company can validate and then design and optimise molecules that interact with these targets. Another model is the classic licensing to a partner of Molecure’s newly discovered molecules that directly model mRNA function. Molecure is one of the few biotech companies in the world that develops small-molecule drugs that directly interact with mRNA targets. About Molecure S.A. Molecure S.A. is a biotechnology company that discovers and develops drugs to the clinical stage, leveraging its own unique expertise in medicinal chemistry and biology to search for and develop first-in-class small-molecule drugs that, through direct modulation of previously unexplored protein and RNA targets, may provide therapies for many incurable diseases. Molecure has generated a diverse portfolio of seven distinct programmes with support from leading academic research institutions around the world, including Yale University, Rutgers University, the Flemish Institute for Biotechnology (VIB) in Ghent, the University of Michigan and the International Institute of Molecular and Cell Biology in Warsaw, Poland (MIBMiK). The most advanced drug candidate developed by Molecure is OATD-01, a first-in-class CHIT1 inhibitor for the treatment of interstitial lung diseases such as sarcoidosis and idiopathic pulmonary fibrosis. The second drug candidate is OATD-02, an oral, selective, first-in-class, dual arginase inhibitor (ARG1 and ARG2) for the treatment of cancer, whose Phase I clinical trial has begun with first patient administration in Q1 2023. Molecure’s headquarters and laboratories are located in Warsaw and Lodz. The company is listed on the Warsaw Stock Exchange (ticker: MOC). Detailed information can be found at: https://molecure.com/pl/ LinkedIn: Molecure | Twitter: @molecure_sa | YouTube: Molecure SA