GPR55

Funding of $1.49 million USD to support the development of KLS-13019 targeting neuroinflammation and mitochondrial dysfunction Kannalife has developed a new class of orally bioavailable drugs to address neurodegenerative and inflammatory diseases by targeting mNCX-1, GPR55 and the NLRP3 inflammasome June 25, 2024 -- Kannalife Sciences, Inc., a pioneering biotech company dedicated to developing small molecule therapeutics targeting inflammation, is pleased to announce it has been awarded funding of $1,493,409 million from The Michael J. Fox Foundation for Parkinson’s Research (MJFF). This grant will support preclinical research of Kannalife’s lead therapeutic KLS-13019 by investigating its effects on neuroinflammation and mitochondrial dysfunction, which are implicated in Parkinson’s disease (PD). Parkinson’s disease is the fastest growing neurodegenerative movement disorder affecting up to 2% of those aged 60 years or older. Douglas Brenneman, PhD, Chief Pharmacologist at Kannalife Sciences and Principal Investigator of the study, expressed gratitude for the Foundation's support, stating, "We are honored to receive this grant support from The Michael J. Fox Foundation, a leading organization dedicated to accelerating the development of improved therapies for Parkinson's disease. We are confident that we can make meaningful progress toward this goal and, ultimately, improve the lives of patients living with Parkinson's." Kannalife Sciences, located at the Pennsylvania Biotechnology Center (PABC) in Doylestown, PA, is leveraging its globally patented technology into neuroinflammatory disorders targeting the novel G protein-coupled receptor (GPCR), GPR55 and the NLRP3 inflammasome. Advanced preclinical research and IND enabling studies to date have validated KLS-13019’s effects on biological targets in the mitochondria including mNCX-1, with the aim of addressing unmet needs in inflammatory diseases. KLS-13019’s promising preclinical results in models of neuroinflammation and oxidative stress, portend to be key factors of neurodegeneration in Parkinson's disease. Jessica Tome Garcia, PhD, associate director of research programs at MJFF, stated, "We look forward to seeing the results of Kannalife Sciences’ innovative work on KLS-13019. This funding highlights the Foundation’s commitment to advancing Parkinson’s therapeutic research by addressing neuroinflammation and mitochondrial dysfunction, two key factors in the disease." Dr. Brenneman further stated, “This grant represents a significant milestone in our research efforts. Special thanks to the whole team at Kannalife, especially Dean Petkanas for his persistence and dedication in mobilizing KLS-13019 into a potential therapeutic for the treatment of Parkinson’s Disease. I also want to thank our research partners Prof. Dr. Med. Chi Wang Ip of Universitätsklinikum Würzburg, Tom H. Johnston, PhD of Atuka, Inc. and James P. Koprich, MA, PhD, for taking the time and effort to put an outstanding study protocol together for our research program in PD.” Through research efforts with MJFF and other partners, the company aims to accelerate the development of KLS-13019 and pave the way for novel therapeutic interventions in Parkinson’s disease and beyond. KLS-13019 is currently undergoing small pre-clinical model efficacy, chemical scale-up, and toxicology studies supported by an STTR Phase 2 study grant from the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) under the HEAL Initiative. Successful completion of these IND enabling studies will allow initiation of human clinical studies for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). This financial support underscores the broad scientific validation of this promising therapeutic agent. The PABC is a nonprofit life sciences incubator-accelerator providing state-of-the-art laboratory and office space to early-stage biotech companies, the Hepatitis B Foundation, and the Blumberg Institute. Managed by the Institute and overseen by a Foundation-appointed board, PABC supports nearly 80 member companies fostering success through biotech advancements and collaborations. Located near Doylestown in the Philadelphia-New Jersey pharma belt, the PABC website offers further information, visit www.pabiotechbc.org. Kannalife Sciences, Inc. is a pioneering biotech company specializing in the development of small molecule synthetic cannabinoid therapeutics targeting inflammation. Headquartered at the Pennsylvania Biotechnology Center of Bucks County in Doylestown, PA, Kannalife Sciences is a wholly owned subsidiary of Neuropathix, Inc. For more information about Kannalife, visit www.kannalife.com and the Company’s Twitter page at @kannalife. The content above comes from the network. if any infringement, please contact us to modify.

Poster presentation details screening approach allowing selection of candidate molecules applicable to dry eye disease and chronic ocular pain, with potential to identify therapeutic candidates with novel mechanisms of action for other ocular pathologiesSAN DIEGO, May 10, 2024 (GLOBE NEWSWIRE) -- Skye Bioscience, Inc. (Nasdaq: SKYE) (“Skye”), a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel classes of therapeutic drugs that modulate the endocannabinoid system (ECS), today announced that it presented new data in a poster titled “Development and screening of a novel library of synthetic endocannabinoid agonists and inhibitors to advance a potential therapy to treat dry eye disease and chronic ocular pain” on May 9th at the ARVO (Association of Research in Vision and Ophthalmology) 2024 Annual Meeting. “The endocannabinoid system offers unique opportunities to address unmet medical needs with new mechanisms of action. At ARVO we showcased Skye’s development and screening of a novel library of synthetic agonists and inhibitors that could potentially fulfill some of these opportunities,” said Punit Dhillon, Chief Executive Officer and Chairman of Skye. Key highlights Presented biological ECS screening program focused on pathways relevant to dry eye disease (DED) and chronic ocular painThree synthetic cannabinoid-based compounds relevant to DED and chronic ocular pain have been identified for further pharmaceutical developmentConclusion: a unique screening approach has the potential to provide a new class of therapeutics with novel mechanisms of action for the treatment of diverse ocular pathologies. Chris Twitty, PhD, Chief Scientific Officer of Skye, added: “Skye’s strategy is to develop advanced pharmaceutical drugs capable of modulating the endocannabinoid system to positively impact ocular pathologies. The study’s evaluation of a novel synthetic cannabinoid-based library with biologically relevant cell types, targets, and pathways enabled the selection of candidate molecules applicable to DED and chronic ocular pain. Ultimately, we selected cannabinerol and two non-electrophilic indolic adducts of cannabidiolquinone and cannabigeroquinone that warrant further interrogation and pharmaceutical development.” Study details A rigorous in vitro screening platform based on modulation of pathways relevant to cannabinoid biology in the context of ocular pathologies was designed to interrogate a library of 98 synthetic cannabinoid-based molecules for their potential to treat ocular diseases. Immortalized human ocular cell lines and stable modified HEK cells were used to measure activation/inhibition of specific cannabinoid receptors, including CB1, CB2, GPR55, and TRPV1. The library was initially interrogated using a threshold of relevant biological activity. The resulting 38 compounds were scored based on EC50/IC50 of signaling (CB1/2/TRPV1/PPARg/NF-kB) and inhibition of ROS and HIF-1a in human epithelial and endothelial (corneal/conjunctival) cells. These compounds were also interrogated for chemical/developability attributes, which helped provide the rationale for ultimately selecting three lead candidate molecules. About Skye Bioscience Skye is focused on unlocking the pharmaceutical potential of the endocannabinoid system to treat diseases with metabolic, inflammatory, and fibrotic processes. Backed by leading life science venture investors, Skye's strategy leverages biologic targets with substantial human proof of mechanism for the development of first-in-class therapeutics with significant clinical and commercial differentiation. Nimacimab, a negative allosteric modulating antibody that inhibits peripheral CB1, showed a favorable safety and tolerability profile in a Phase 1 study. Skye plans to start a Phase 2 clinical trial in obesity comparing monotherapy and combination arms of Nimacimab and a GLP-1R agonist in mid-2024. Enrollment has been completed for a Phase 2 clinical trial of SBI-100 Ophthalmic Emulsion, a CB1 agonist currently being studied in patients with glaucoma and ocular hypertension. Topline data for this study is expected in Q2 2024. For more information, please visit: https://www.skyebioscience.com. CONTACTInvestor Relationsir@skyebioscience.com(858) 410-0266 LifeSci Advisors, Mike Moyermmoyer@lifesciadvisors.com617-308-4306 Media InquiriesLifeSci Communications, Michael Fitzhughmfitzhugh@lifescicomms.com(628) 234-3889 FORWARD LOOKING STATEMENTSThis letter contains forward-looking statements, including statements regarding our product development, business strategy, the timing of clinical trials, and commercialization of cannabinoid-derived therapeutics. Such statements and other statements in this press release that are not descriptions of historical facts are forward-looking statements that are based on management’s current expectations and assumptions and are subject to risks and uncertainties. If such risks or uncertainties materialize or such assumptions prove incorrect, our business, operating results, financial condition, and stock price could be materially negatively affected. In some cases, forward-looking statements can be identified by terminology including “anticipated,” “plans,” “goal,” “focus,” “aims,” “intends,” “believes,” “can,” “could,” “challenge,” “predictable,” “will,” “would,” “may” or the negative of these terms or other comparable terminology. We operate in a rapidly changing environment, and new risks emerge from time to time. As a result, it is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements the Company may make. Risks and uncertainties that may cause actual results to differ materially include, among others, our capital resources, uncertainty regarding the results of future testing and development efforts and other risks that are described in the Risk Factors section of Skye’s most recent annual or quarterly report filed with the Securities and Exchange Commission. Except as expressly required by law, Skye disclaims any intent or obligation to update these forward-looking statements.

BOSTON, March 21, 2023 (GLOBE NEWSWIRE) -- Cerevance, a private, clinical-stage drug discovery and development company focused on developing novel therapeutics for central nervous system (CNS) diseases using the company’s proprietary Nuclear Enriched Transcript Sort sequencing (NETSseq) platform, today announced plans to present at two upcoming medicinal chemistry conferences. 7th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets held March 27-28 in Cambridge, UK Binding Kinetics and Mechanistic PK/PD Modeling in Early Drug Discovery Conference held March 27-28 in Cambridge, UK 7th RSC-BMCS / SCI Symposium on Ion Channels as Therapeutic Targets Conference Presentation details Title: Identification of THIK-1 as a therapeutic target for neuroinflammatory diseases: Discovery and characterisation of a selective THIK-1 blocker Overview: The NETSseq platform can identify unexplored and druggable microglia targets, exemplified by THIK-1, as potential therapies for neurodegenerative diseases. The discovery of a THIK-1 inhibitor, C101248, and its pharmacological profile, as well as its effect in microglia, is explored. Presenter: Anna Rowland, PhD Session Date and Time: March 27, 2023, 1:30-2:45pm Binding Kinetics and Mechanistic PK/PD Modeling in Early Drug Discovery Conference Poster details Title: Analysis of the Initial Velocity of Calcium Signalling and β-Arrestin Recruitment at GPR55 with Different Activators Shows Unique Signalling Profiles Overview: Three proprietary small molecule activators of GPR55 display unique signalling profiles when measuring the initial velocity of calcium and β-arrestin pathway activation. Presenter: Philip Pickford Poster Number: 10 About Cerevance Cerevance is a private pharmaceutical company with a focus on CNS disorders. CVN424, Cerevance’s lead therapeutic, is a first-in-class, oral, non-dopaminergic compound acting on a novel target (GPR6), that demonstrated significant and clinically meaningful efficacy in a 136-patient Phase 2 study in patients with Parkinson’s disease. The company uses its proprietary Nuclear Enriched Transcript Sort sequencing (NETSseq) platform to identify highly selectively expressed, novel target proteins that are either specific to certain brain circuits or are over- or under-expressed in diseased brains. Partnering with over 25 brain banks and evaluating an expanding collection of more than 12,000 human post-mortem brain tissue samples, Cerevance is advancing a robust pipeline of targeted treatments for patients with neurodegenerative diseases, including Parkinson’s disease, Amyotrophic Lateral Sclerosis and Alzheimer’s disease. For additional information, please visit Contacts Cerevance: Johnna Simoes, ir@cerevance.com Media: Andrew Mielach, amielach@lifescicomms.com, +1-646-876-5868