QPCT

Vivoryon Therapeutics N.V. Presents Outstanding Phase 2b Results of Varoglutamstat on Kidney Function at ASN Kidney Week 2024 Selected for late-breaking oral presentation at ASN kidney week, the world’s premier nephrology meetingResults presented show a statistically significant and clinically meaningful improvement of the prospectively defined kidney function parameter eGFR1 by 3.4mL/min/year (p<0.0001) in the varoglutamstat arm compared to placebo Results in the subgroup of patients with diabetes2 showed an 8.2mL/min/year difference in favor of varoglutamstat (p=0.02)The results were consistent in several sensitivity analyses including using the CKD-EPI 2021 formula for both creatinine and cystatin-CVaroglutamstat demonstrated an excellent safety and tolerability profile and there were no signs of increased proteinuriaA new Phase 2 study is in planning to confirm the effect in patients with DKD3 stage 3b and 4 Halle (Saale) / Munich, Germany, October 26, 2024 – Vivoryon Therapeutics N.V. (Euronext Amsterdam: VVY; NL00150002Q7) (Vivoryon), a clinical stage company focused on the discovery and development of small molecule medicines to modulate the activity and stability of pathologically altered proteins, today announced highlights from a late-breaking oral presentation held yesterday, October 25, 2024, at the American Society of Nephrology (ASN) Kidney Week 2024 in San Diego, California. The presentation by the Company’s CEO, Frank Weber, M.D. titled “Varoglutamstat Increases Glomerular Filtration in Elderly Patients without Signs of Proteinuria and Potentially Offers a New Approach to Treat Diabetic Kidney Disease (DKD)” featured Phase 2 clinical study data substantiating the opportunity to further develop varoglutamstat, Vivoryon’s Phase 2 investigational medicine with the potential to improve kidney function, in people with kidney disease. “We’re privileged to have been accepted to share the exciting results of varoglutamstat on kidney function with so many scientific and medical experts in the kidney field. Varoglutamstat showed statistically significant and clinically meaningful improvements of eGFR versus placebo and a sustained improvement of eGFR above baseline, potentially indicating partial recovery of the kidney. We are grateful for many fruitful discussions and extremely encouraged by the positive reactions we received from the community,” said Frank Weber, M.D., CEO of Vivoryon. “The efficacy and safety data presented at ASN represent a unique profile for an oral product for treating kidney disorders and guide the future development of varoglutamstat. Our primary focus is delivering a much-needed novel treatment option for patients suffering from DKD. Beyond this, we see potential for varoglutamstat across a broad range of kidney diseases including rare diseases affecting kidney function, such as Fabry disease and Alport syndrome.” Presentation Highlights Background: Varoglutamstat is a specific and selective inhibitor of glutaminyl cyclases and confers a novel mechanism of action that attenuates inflammation and fibrosis through reduction of pyroglutamized versions of chemokines and pro-fibrotic peptides, thereby positively impacting kidney function.Assessment of progression of kidney dysfunction as measured by the eGFR slope4 was included prospectively in VIVIAD (NCT04498650), Vivoryon’s Phase 2b multicenter, randomized, double-blind, placebo-controlled, parallel group dose-finding study in 259 patients in Alzheimer’s disease.The average age of participants in VIVIAD was >68 years, dosing was twice-daily with either 300mg or 600mg varoglutamstat, or placebo and treatment duration was 48-96 weeks; key kidney-related study features included a mean baseline eGFR of ~80mL/min/1.73m2, eGFR, urine dipstick and vital signs measured every 12 weeks; the diabetes subgroup comprised ~12% of VIVIAD patients. Compelling efficacy and safety data in elderly people at risk for kidney disease: eGFR improved significantly for varoglutamstat compared to placebo and above baseline in both total population and diabetes subgroup, with the latter revealing a substantially higher treatment effect5 of >8.2mL/min/1.73m2/year (p=0.02; varoglutamstat n=20 / placebo n=12) compared to the overall VIVIAD study population (3.4mL/min/1.73m2/year (p<0.001; varoglutamstat n=141 / placebo n=117)).Results and effect size were consistent using a set of diverse and validated methods for eGFR assessment (2021 CKD-EPI cystatin C, 2021 CKD-EPI creatinine-cystatin C 2021 CKD-EPI creatinine, MDRD6).Urine dipstick analysis showed no evidence of increased proteinuria in the treatment group compared to placebo, with the majority of study participants having no proteinuria through all time points measured in the study.Robust safety data confirmed varoglutamstat’s excellent safety profile consistent across two years study duration with no adverse kidney effects and no meaningful differences observed in renal and metabolic systems adverse events in both total population and diabetes subgroup. Next steps: Placebo-controlled Phase 2 study in stage 3b/4 DKD patients on top of SoC in planning to confirm the results to date and investigate additional endpoints including albuminuria/proteinuria, inflammation and fibrosis-related biomarkers.Pre-clinical investigation of additional rare/orphan kidney disorders (Alport syndrome, Fabry disease). 1 Estimated glomerular filtration rate (eGFR), a validated measure of kidney function, was calculated as a slope analysis across two years taking all available data into account. 2 Diabetes subgroup defined as patients having at baseline either medical history of diabetes (type 1 or 2) and/or comedication with drugs used in diabetes and/or untreated with an HbA1c > 6.5%. 3 The timing and execution of the planned Phase 2 study in diabetic kidney disease is subject to additional funding / partnership. 4 Measuring the eGFR slope via random coefficients (RC) analysis was the primary efficacy endpoint in recent FDA approvals in CKD, as well as in many ongoing Phase 3 studies. 5 Treatment effect – the between-group difference in eGFR slope between varoglutamstat and placebo. 6 Estimated glomerular filtration rate based on creatinine and calculated using modification of diet in renal disease (MDRD) method. ### Varoglutamstat in Kidney DiseaseVaroglutamstat (PQ912) is a proprietary, potent and selective inhibitor of human glutaminyl cyclases QPCT and QPCTL with therapeutic potential in indications including inflammatory and fibrotic diseases, neurodegenerative diseases, cancer and others. Initially advancing development aiming to treat Alzheimer’s disease (AD), varoglutamstat has been investigated in a number of different clinical studies, all of which have consistently demonstrated a favorable safety and tolerability profile both in healthy volunteers and patients with AD. Based on the known anti-inflammatory activity of varoglutamstat, the protocol for the Phase 2 VIVIAD study in AD, which was completed in the first half of 2024, included the investigation of kidney function and measurement of biomarkers of kidney inflammation and fibrosis to explore the role of QPCT/L inhibition on kidney function. Although patients in VIVIAD were selected for their AD status and not for their kidney function level, many of them had reduced kidney function due to age and/or comorbidities. Analysis showed a statistically significant benefit of varoglutamstat on a prospectively defined key kidney function endpoint (eGFR) and a significant reduction of the pro-inflammatory cytokine pE-CCL2. A substantially higher treatment benefit of varoglutamstat on eGFR was observed in a post-hoc diabetes subgroup, triggering plans to advance varoglutamstat into Phase 2 study in DKD, which is currently in planning. About Vivoryon Therapeutics N.V.Vivoryon is a clinical stage biotechnology company focused on developing innovative small molecule-based medicines. Driven by its passion for ground-breaking science and innovation, the Company strives to change the lives of patients in need suffering from severe diseases. The Company leverages its in-depth expertise in understanding post-translational modifications to develop medicines that modulate the activity and stability of proteins which are altered in disease settings. The Company has established a pipeline of orally available small molecule inhibitors for various indications including Alzheimer’s disease, inflammatory and fibrotic disorders, including of the kidney, and cancer. www.vivoryon.com. Vivoryon Forward Looking StatementsThis press release includes forward-looking statements, including, without limitation, those regarding the business strategy, management plans and objectives for future operations of Vivoryon Therapeutics N.V. (the “Company”), estimates and projections with respect to the market for the Company’s products and forecasts and statements as to when the Company’s products may be available. Words such as “anticipate,” “believe,” “estimate,” “expect,” “forecast,” “intend,” “may,” “plan,” “project,” “predict,” “should” and “will” and similar expressions as they relate to the Company are intended to identify such forward-looking statements. These forward-looking statements are not guarantees of future performance; rather they are based on the Management’s current expectations and assumptions about future events and trends, the economy and other future conditions. The forward-looking statements involve a number of known and unknown risks and uncertainties. These risks and uncertainties and other factors could materially adversely affect the outcome and financial effects of the plans and events described herein. The Company’s results of operations, cash needs, financial condition, liquidity, prospects, future transactions, strategies or events may differ materially from those expressed or implied in such forward-looking statements and from expectations. As a result, no undue reliance should be placed on such forward-looking statements. This press release does not contain risk factors. Certain risk factors that may affect the Company’s future financial results are discussed in the published annual financial statements of the Company. This press release, including any forward-looking statements, speaks only as of the date of this press release. The Company does not assume any obligation to update any information or forward-looking statements contained herein, save for any information required to be disclosed by law. For more information, please contact: Investor ContactVivoryon Therapeutics N.V.Dr. Manuela Bader, Director IR & CommunicationEmail: IR@vivoryon.com Media ContactTrophic CommunicationsValeria Fisher or Verena SchossmannTel: +49 175 8041816 / +49 151 219 412 77Email: vivoryon@trophic.eu Attachment 20241026_Vivoryon_ASN_KidneyWeek_Data

Halle (Saale) / Munich, Germany, October 1, 2024 – Vivoryon Therapeutics N.V. (Euronext Amsterdam: VVY; NL00150002Q7) (Vivoryon), a clinical stage company focused on the discovery and development of small molecule medicines to modulate the activity and stability of pathologically altered proteins, today announced key takeaways from its virtual Kidney Disease Key Opinion Leader (KOL) Event held September 30, 2024. The event focused on the standard of care and existing medical need, market development and dynamics in kidney disorders, as well as on key statistical considerations in kidney disease drug development, with special emphasis on diabetic kidney disease (DKD). The event, which was hosted by Frank Weber, MD, CEO of Vivoryon, featured presentations from Tobias B. Huber, MD, Chair of the Center of Internal Medicine and Director of the III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Florian Jehle, renal pharmaceutical industry expert and Kevin Carroll, PhD, CEO, KJC Statistics. “Our KOL event has shed light on the profound existing medical need of halting disease progression in kidney disease. It clearly outlined that, despite a number of treatments available and scientific advances made in this field over the past years, novel medicines are needed with mechanisms of action suitable to addressing the key inflammatory and fibrotic pathways underlying this disease,” said Frank Weber, MD, CEO of Vivoryon. “I would like to thank all speakers for participating and sharing their knowledge and unique perspectives shaped by their core expertise in key aspects of drug development in kidney disease. Building on the strong body of evidence of varoglutamstat’s ability to protect and improve kidney function, observed in particular in patients with diabetes, we now look forward to keeping the market updated on our progress in fully realizing the potential of Vivoryon’s lead asset varoglutamstat in kidney disease.” Highlights from Dr. Huber’s presentation include: Chronic Kidney Disease (CKD) is a rising global health problem and is set to become the fifth leading cause of years of life lost by 2040.Treatments for CKD have advanced in recent years but still do not halt or reverse kidney function decline which will likely increase as the population ages.CKD manifests as a progressive decline in kidney function and can lead to significant disability and/or premature death and diabetes is a major risk factor for CKD.Inflammation is a key underlying pathway in driving progression of diabetic kidney disease (DKD) and other kidney disorders and targeting inflammatory pathways could represent an approach to address the unmet needs across both the broader CKD population as well as in the rare disease space.Observations from the VIVIAD Phase 2b study have shown that varoglutamstat, with its novel mode of action targeting inflammatory and fibrotic pathways and promising efficacy and safety profile to date, could become an interesting treatment option for patients, if proven successful in double blinded, randomized prospective clinical studies. Highlights from Mr. Jehle’s presentation include: Late-stage CKD patients are at greatest risk of kidney failure requiring kidney replacement therapy (dialysis or transplant). End-stage renal disease and kidney failure is a major concern for not only patients and physicians, but also health care providers and payors, with costs escalating significantly with later stages of the disease.Rate of cardio-metabolic risk factors such as diabetes and hypertension as well as age are key dynamics in the CKD market. Current therapies such as SGLT2s and GLP1s only delay disease progression, but are no cure, consequently, a high unmet need remains for the majority of CKD and DKD patients.There is a significant market potential for oral varoglutamstat, in particular in the stage 4 and fast progressing stage 3b CKD and DKD patient populations, as well as certain rare diseases such as Alport syndrome and Fabry disease.Increasing interest from big pharma in kidney diseases has been demonstrated by recent deals with high valuations. Highlights from Dr. Carroll’s presentation include: Analysis of the estimated glomerular filtration rate (eGFR) in CKD studies have evolved over the past 40 years and novel methods for statistical analysis are being applied, with the Random Coefficients (RC) Analysis emerging as preferred method.Measuring the eGFR slope via RC analysis was the primary efficacy endpoint in recent FDA approvals in CKD, as well as in many ongoing Phase 3 studies. Analysis of data from the VIVIAD study employing this method has yielded consistent findings for eGFR with varoglutamstat, with a substantial treatment effect on the eGFR slope seen for varoglutamstat compared to placebo in the overall population driven by an even larger effect in patients with type 2 diabetes.Available results from VIVIAD together with good statistical planning enables an efficient design of a Phase 2 study in patients with DKD stage 3/4 with an interim futility analysis after 62 patients treated for at least 24 weeks. A replay of the webcast of the virtual R&D Event will be available via the Presentations & Webcasts page in the Investor Relations section on the Company's website at www.vivoryon.com. ### Varoglutamstat in Kidney DiseaseVaroglutamstat (PQ912) is a proprietary, potent and selective inhibitor of human glutaminyl cyclases QPCT and QPCTL with therapeutic potential in indications including inflammatory and fibrotic diseases, neurodegenerative diseases, cancer and others. Initially advancing development aiming to treat Alzheimer’s disease (AD), varoglutamstat has been investigated in a number of different clinical studies, all of which have consistently demonstrated a favorable safety and tolerability profile both in healthy volunteers and patients with AD. Based on the known anti-inflammatory activity of varoglutamstat, the protocol for the Phase 2 VIVIAD study in AD, which was completed in the first half of 2024, included the investigation of kidney function and measurement of biomarkers of kidney inflammation and fibrosis to explore the role of QPCT/L inhibition on kidney function. Although patients in VIVIAD were selected for their AD status and not for their kidney function level, many of them had reduced kidney function due to age and/or comorbidities. Analysis showed a statistically significant benefit of varoglutamstat on a prospectively defined key kidney function endpoint (eGFR) and a significant reduction of the pro-inflammatory cytokine pE-CCL2. A substantially higher treatment benefit of varoglutamstat on eGFR was observed in a post-hoc diabetes subgroup, triggering plans to advance varoglutamstat into Phase 2 study in DKD, which is currently in planning. About Vivoryon Therapeutics N.V.Vivoryon is a clinical stage biotechnology company focused on developing innovative small molecule-based medicines. Driven by its passion for ground-breaking science and innovation, the Company strives to change the lives of patients in need suffering from severe diseases. The Company leverages its in-depth expertise in understanding post-translational modifications to develop medicines that modulate the activity and stability of proteins which are altered in disease settings. The Company has established a pipeline of orally available small molecule inhibitors for various indications including Alzheimer’s disease, inflammatory and fibrotic disorders, including of the kidney, and cancer. www.vivoryon.com. Vivoryon Forward Looking StatementsThis press release includes forward-looking statements, including, without limitation, those regarding the business strategy, management plans and objectives for future operations of Vivoryon Therapeutics N.V. (the “Company”), estimates and projections with respect to the market for the Company’s products and forecasts and statements as to when the Company’s products may be available. Words such as “anticipate,” “believe,” “estimate,” “expect,” “forecast,” “intend,” “may,” “plan,” “project,” “predict,” “should” and “will” and similar expressions as they relate to the Company are intended to identify such forward-looking statements. These forward-looking statements are not guarantees of future performance; rather they are based on the Management’s current expectations and assumptions about future events and trends, the economy and other future conditions. The forward-looking statements involve a number of known and unknown risks and uncertainties. These risks and uncertainties and other factors could materially adversely affect the outcome and financial effects of the plans and events described herein. The Company’s results of operations, cash needs, financial condition, liquidity, prospects, future transactions, strategies or events may differ materially from those expressed or implied in such forward-looking statements and from expectations. As a result, no undue reliance should be placed on such forward-looking statements. This press release does not contain risk factors. Certain risk factors that may affect the Company’s future financial results are discussed in the published annual financial statements of the Company. This press release, including any forward-looking statements, speaks only as of the date of this press release. The Company does not assume any obligation to update any information or forward-looking statements contained herein, save for any information required to be disclosed by law. For more information, please contact: Investor Contact Vivoryon Therapeutics N.V. Dr. Manuela Bader, Director IR & Communication Email: IR@vivoryon.com Media Contact Trophic CommunicationsStephanie MayTel: +49 171 1855682Email: vivoryon@trophic.eu Attachment 241002_VVY_KOL Event Highlights_Final

Vivoryon Therapeutics N.V. Reports H1 2024 Progress Marked by Compelling Kidney Function Data and Execution of Strategy to Advance Varoglutamstat in Kidney Disease Primary focus is developing varoglutamstat, a Phase 2 investigational medicine with potential to improve kidney function in patients with kidney diseaseStatistically significant benefit of varoglutamstat on prospectively defined key kidney function endpoint (eGFR1) and significant reduction of pro-inflammatory cytokine pE-CCL2 observed in VIVIAD Phase 2b AD studySubstantially higher treatment benefit of varoglutamstat on eGFR observed in post-hoc diabetes subgroup2 triggering plans to advance varoglutamstat into Phase 2 study in DKD3Gained further insight into AD results through clear evidence of differences between kidney and AD outcomes from PK/PD analysis and new target occupancy information Management to host a conference call today at 3:00pm CEST (9:00am EDT)Vivoryon to host a virtual Kidney Disease KOL (Key Opinion Leaders) webcast on Monday, September 30 at 3:00 pm CEST (9:00 am EDT) to elaborate on varoglutamstat’s potential in kidney disease with an emphasis on DKD Halle (Saale) / Munich, Germany, September 12, 2024 - Vivoryon Therapeutics N.V. (Euronext Amsterdam: VVY; NL00150002Q7) (Vivoryon), a clinical stage company focused on the discovery and development of small molecule medicines to modulate the activity and stability of pathologically altered proteins, today announced financial results for the six-month period ended June 30, 2024, and provides a corporate update. The report is available on the Company’s website https://www.vivoryon.com/financial-information/. “The VIVIAD Phase 2b study showed outstanding results in improving kidney function and we made strong progress during the first half of 2024 in forging a new development strategy for varoglutamstat in diabetic kidney disease (DKD),” said Frank Weber, MD, CEO of Vivoryon. “In parallel, we advanced pharmacokinetic and biomarker analyses which demonstrate a strong dose response of varoglutamstat on kidney function improvement. Furthermore, as we continue the evolution of our understanding of the Alzheimer’s disease (AD) VIVIAD results, we have generated the first evidence that varoglutamstat activity is required in the cells of the brain – not only in the cerebrospinal fluid - to stop the pathological process of pE-Abeta production.” He concluded, “The VIVIAD data demonstrate varoglutamstat has an excellent safety and tolerability profile, provide strong support for our understanding of the potential of QPCTL inhibitors in inflammatory and fibrotic diseases and lay the foundation for our strategic shift towards kidney disease based on the outstanding effect we observed on eGFR.” H1 2024 and Post-Period Updates Strategic shift towards a focus on inflammatory and fibrotic diseases A significant positive effect of varoglutamstat on kidney function observed in the VIVIAD Phase 2b study in AD underpins the strategic shift to inflammatory and fibrotic diseases. In April 2024, Vivoryon announced this strategic shift following the announcement in March 2024 that the VIVIAD Phase 2b study did not achieve its primary and key secondary endpoints in early AD. The VIVIAD protocol prospectively specified measurement of kidney function by estimated glomerular filtration rate (eGFR), a primary endpoint in many development programs of kidney disorders, and additional biomarkers, in order to further investigate this potential activity. Key priorities now include: Preparing for a proposed Phase 2 clinical study for varoglutamstat in diabetic kidney disease (subject to additional funding and/or partnership);Concluding VIVIAD Phase 2b clinical study program and in-depth analysis;Analyzing the data of the VIVA-MIND Phase 2 clinical study with varoglutamstat in the U.S. in early AD by year end 2024;Continuing to actively pursue potential business development and financing opportunities. Varoglutamstat Mechanism of Action Post-translational modification occurs both physiologically and in disease settings and it is a crucial process to functionalize proteins. Many different post-translational modifications are catalyzed by enzymes that have become known drug targets, e.g. kinases, proteases, or methylases.Pyroglutamate (pE) formation, a specific post-translational modification catalyzed by the glutaminyl cyclase enzymes QPCT and QPCTL, has emerged as a central element in different diseases including neurodegenerative, inflammatory and fibrotic diseases as well as cancer.Varoglutamstat is a highly potent oral small molecule inhibitor of human QPCT and QPCTL, designed to prevent inflammatory and fibrotic processes by blocking pyroglutamate formation on key disease drivers.QPCTL inhibition has demonstrated robust evidence of efficacy in animal models of inflammatory and fibrotic disorders such as glomerulonephritis and non-alcoholic steatohepatitis (NASH). Varoglutamstat – VIVIAD kidney function results (total study population) Varoglutamstat 600mg BID increased eGFR over the treatment period up to 96 weeks in patients with early AD, indicating a potential benefit of varoglutamstat on kidney function. The treatment effect in the overall VIVIAD study population was 3.4mL/min/1.73m2/year (p<0.001; varoglutamstat n=141 / placebo n=117).Further sensitivity and subgroup analysis has shown this effect is observed across the range of eGFR levels at baseline in the study, and when assessed using a set of diverse and validated methods for calculating kidney function.Additionally, the Company has explored the effect of varoglutamstat on levels of pyroglu-CCL2 (pE-CCL2), a pro-inflammatory cytokine. Persistent, low grade inflammation is considered a hallmark feature of chronic kidney disease (CKD). Results showed a significant and dose-dependent reduction in pE-CCL2 in the serum of VIVIAD patients following treatment with varoglutamstat. This demonstrates the effectiveness of varoglutamstat in inhibiting systemic intracellular QPCTL and strongly supports an anti-inflammatory effect. Significant effects of varoglutamstat in diabetes subgroup2 Analysis of eGFR in a subgroup of patients with diabetes2 in the VIVIAD Phase 2b study reveals a substantially higher treatment effect4 of >8mL/min/1.73m2/year (p=0.02; varoglutamstat n=20 / placebo n=12) compared to the overall VIVIAD study population where the treatment effect was 3.4mL/min/1.73m2/year (p<0.001; varoglutamstat n=141 / placebo n=117).Promising additional effects were observed in the diabetes subgroup in varoglutamstat treated patients including a reduction in liver transaminases, mild weight loss, and a reduction in diastolic blood pressure.Data revealed that the positive effect on kidney function in the diabetes subgroup appears to be independent of any change in glycemic control (HbA1C remained steady over the period for the varoglutamstat group).A reduction of the plasma concentration of the inflammatory and fibrosis inducing pE-CCL2 (p=0.004) was observed in the varoglutamstat arm, indicating a strong anti-inflammatory effect.Varoglutamstat was well-tolerated at the dose tested (up to 600mg twice daily) and there were no meaningful differences in adverse events observed in renal and metabolic system organ classes versus placebo or the total population. Proposed Clinical Development Plan in Diabetic Kidney Disease (DKD)3 Despite advances in the standard of care for DKD, there remains a significant unmet need for new therapies to stabilize kidney function and prevent disease progression.Vivoryon plans to start a Phase 2 study in DKD that is intended to include patients with disease stages more advanced than those observed in the VIVIAD Phase 2 study, enabling an expansion of the overall target patient population. The Company envisages a placebo-controlled study of up to approximately 120 subjects with stage 3b/4 DKD. These subjects would be randomized 1:1 to varoglutamstat 600mg twice daily or placebo, on top of standard of care medications. Key endpoints are planned to include eGFR slope analysis, measures of albuminuria (UA(p)CR), inflammation and fibrosis-related biomarkers, as well as safety.Vivoryon is evaluating business development and financing opportunities, to further explore the potential of varoglutamstat and QPCT/L inhibitors in kidney disease in both large indications, such as DKD, and in certain rare diseases that impact kidney function, such as Fabry disease and Alport Syndrome. Varoglutamstat – early Alzheimer’s disease (AD) Vivoryon has continued its in-depth analysis of the VIVIAD data. Findings to date continue to confirm there is no consistent effect of varoglutamstat up to 600mg BID on cognition and function, including in high exposure patients. Results from pharmacokinetic, pharmacodynamic and biomarker data, including an assay for measuring pE-Abeta forms, suggests that intracellular QPCT may play a greater role in driving clinical outcomes in AD. Data from VIVA-MIND, anticipated by the end of 2024, is expected to contribute to the overall dataset informing varoglutamstat’s development strategy in AD. Corporate Development Updates In March 2024, Kugan Sathiyanandarajah and Professor Dr. Morten Asser Karsdal stepped down from Vivoryon’s Board of Directors. They had been appointed as Non-Executive Directors in June 2023.In March 2024, Anne Doering, CFA, assumed the role of Chief Financial Officer (CFO) of Vivoryon, following her previous position as Chief Strategy & Investor Relations Officer.Vivoryon held its 2024 Annual General Meeting (AGM) on Friday, June 21, 2024, at 1:00 p.m. (CEST) in Amsterdam, the Netherlands. The shareholders approved all items on the agenda of the meeting. The full agenda and all relevant documents are available on the Company’s website (https://www.vivoryon.com/2024-annual-general-meeting/). Agenda items of particular note include the reappointment of Dr. Michael Schaeffer, Chief Business Officer, as executive director as well as the amendment to the Company’s articles of association with regard to, among other changes, the decrease of the nominal value of the shares in the capital of the Company to EUR 0.01 from EUR 1.00, which was implemented on September 5, 2024. Financial Results for the First Half of 2024 Revenues were zero in the six months ended June 30, 2024, as well as in the six months ended June 30, 2023. Research and development expenses increased by EUR 4.0 million to EUR 10.3 million in the six months ended June 30, 2024, compared to EUR 6.3 million in the six months ended June 30, 2023. This increase was largely attributable to the increase in clinical development costs from the VIVIAD and VIVA-MIND studies as well as early investments into kidney related research. General and administrative expenses were EUR 3.5 million in the six months ended June 30, 2024, compared to EUR 4.4 million in the six months ended June 30, 2023. The decrease of EUR 0.9 million was largely attributable to higher non-executive board compensation in 2023. Net loss for the six months ended June 30, 2024, was EUR 13.6 million, compared to EUR 10.7 million for the six months ended June 30, 2023. The Company held EUR 15.3 million in cash and cash equivalents as of June 30, 2024, compared to EUR 28.6 million, which includes cash and cash equivalents and term deposits within financial assets, as of December 31, 2023. Cash utilization for the first six months of 2024 reflects the intensive investment period in VIVIAD and VIVA-MIND, both of which are expected to meaningfully ramp down in the second half 2024 as both studies approach their conclusion. Outlook & Financial Guidance As published on April 24, 2024, the Company expects, on the basis of its most recent financial and business plan, that its existing cash and cash equivalents will be sufficient to fund its operating plans, excluding any additional financings, into the second quarter of 2025. This cash runway guidance reflects the shift in focus of research and development resources towards inflammatory and fibrotic disorders, such as of the kidney, and an overall reduction in cash utilization including the ramp down of spending on VIVIAD as it approaches its conclusion, the discontinuation of VIVA-MIND, the discontinuation of VIVALONG preparation activities given the developments of VIVIAD and VIVA-MIND, as well as the streamlining of manufacturing costs and programs for API development. The viability of the Company beyond the second quarter of 2025 is dependent on its ability to raise additional funds to finance its operations which also depends on the success of its research and development activities such as those focusing on exploring opportunities in kidney disease. Conference Call and WebcastVivoryon will host a conference call and webcast today, September 12, 2024, at 3:00 pm CEST (9:00 am EDT). A Q&A session will follow the presentation of the first half 2024 results.A live webcast and slides will be made available at: https://www.vivoryon.com/news-and-events/presentations-webcasts/ To join the conference call via phone, participants may pre-register and will receive dedicated dial-in details to easily and quickly access the call via the following website: https://register.vevent.com/register/BIb82f5f65fffe4d5faaade135258da32a It is suggested participants dial into the conference call 15 minutes prior to the scheduled start time to avoid any delays in attendance. Approximately one day after the call, a slide-synchronized audio replay of the conference will be available on: https://www.vivoryon.com/news-and-events/presentations-webcasts/ Virtual Kidney Disease Key Opinion Leaders Event on September 30, 2024 Vivoryon will host a virtual Kidney Disease KOL (Key Opinion Leaders) conference call and webcast on Monday, September 30, 2024, featuring expert presentations by seasoned KOLs followed by a Q&A session on the standard of care and existing medical need, market development and commercial potential in kidney disorders, as well as evidence generation and statistical principles in kidney disease drug development, with special emphasis on diabetic kidney disease. Featured speakers: Tobias B. Huber, MD - Chair of the Center of Internal Medicine and Director of the III. Department of Medicine - University Medical Center Hamburg-Eppendorf (UKE), Germany. Acting as Medical Advisor for clinical study design. Research collaboration with Vivoryon focusing on pre-clinical and mechanistic activities relating to varoglutamstat and the role of QPCT/L on kidney function.Florian Jehle - CEO of Vifor-FMC Renal Pharma. Acting as Industry Expert Advisor to Vivoryon in the kidney field including strategic business and commercial advice.Kevin Carroll, PhD - CEO, KJC Statistics. Acting as statistical analysis expert, providing and calculating statistical read-outs and advising on clinical study statistical aspects. Conference call detailsDate: September 30, 2024Time: 3:00 pm CEST / 9:00 am EDTA live webcast and slides will be made available at: https://www.vivoryon.com/news-and-events/presentations-webcasts/ Please register to join the conference call via the following website: https://edge.media-server.com/mmc/p/b8g57xvh/ ### Vivoryon Therapeutics N.V. Financial StatementsUnaudited Statement of Operations and Comprehensive Loss for the Six Months Ended June 30, 2024 and 2023 For the six months ended June 30,in kEUR, except for share data2024(unaudited)2023(unaudited) Research and development expenses(10,308)(6,259)General and administrative expenses(3,501)(4,433)Operating loss(13,809)(10,692)Finance income303258Finance expenses(53)(327)Finance result250(69)Result before income taxes(13,559)(10,761)Income taxes—45Net loss for the period(13,559)(10,716)Items not to be reclassified subsequently to profit or loss Remeasurement of the net defined benefit pension liability39(9)Total other comprehensive profit / (loss)39(9)Comprehensive loss(13,520)(10,725)Loss per share in EUR (basic and diluted)(0.52)(0.44) The accompanying notes are an integral part of these condensed interim financial statements. Vivoryon Therapeutics N.V.Unaudited Condensed Statements of Financial Position as of June 30, 2024 and December 31, 2023 (audited) in kEURJune 30,2024(unaudited)December 31,2023(audited)ASSETS Non-current assets Property, plant and equipment3140Intangible assets904941Right-of-use assets936Total non-current assets9441,017Current assets Financial assets7410,165Other current assets and prepayments7011,085Cash and cash equivalents15,27218,562Total current assets16,04729,812TOTAL ASSETS16,99130,829 Equity Share capital26,06726,067Share premium135,671135,671Other capital reserves14,81713,599Accumulated other comprehensive loss(217)(256)Accumulated deficit(162,358)(148,799)Total equity13,98026,282Non-current liabilities Pension liability1,2871,353Provisions long-term1212Total non-current liabilities 1,2991,365Current liabilities Trade payables1,4652,894Lease liabilities1038Other liabilities237250Total current liabilities1,7123,182Total Liabilities3,0114,547TOTAL EQUITY AND LIABILITIES16,99130,829 The accompanying notes are an integral part of these condensed interim financial statements. Vivoryon Therapeutics N.V.Unaudited Condensed Statements of Changes in Shareholders’ Equity for the six months ended June 30, 2024 and 2023 in kEURShare capitalSharepremiumOthercapital reservesAccumulated othercomprehensivelossAccumulated deficitTotal equity January 1, 202426,067135,67113,599(256)(148,799)26,282Net loss for the period————(13,559)(13,559)Remeasurement of the net defined benefit pension liability———39—39Comprehensive loss———39(13,559)(13,520)Proceeds from the issuance of common shares——————Transaction costs of equity transactions——————Share-based payments——1,218——1,218Exercise of share options——————June 30, 202426,067135,67114,817(217)(162,358)13,980 January 1, 202324,105113,3829,656(180)(120,457)26,506Net loss for the period————(10,716)(10,716)Remeasurement of the net defined benefit pension liability———(9)—(9)Comprehensive loss———(9)(10,716)(10,725)Proceeds from the issuance of common shares1,78623,214———25,000Transactions costs of equity transactions—(2,095)———(2,095)Exercise of share options——2,305——2,305Share-based payments71472———542June 30, 202325,962134,97311,961(189)(131,173)41,534 The accompanying notes are an integral part of these condensed interim financial statements. Vivoryon Therapeutics N.V. Unaudited Condensed Statements of Cash Flows for the six months ended June 30, 2024 and 2023 For the six months ended June 30,in kEUR2024(unaudited)2023(unaudited) Operating activities Net loss for the period(13,559)(10,716)Adjustments for: Finance result(250)69Depreciation and amortization7379Share based payments1,2182,305Foreign currency gain (loss) from other items than cash(25)(59)Deferred income tax—(45)Other non-cash adjustments19(33)Changing in: Financial assets(4)(8,938)Other current assets and prepayments383(2,036)Pension liabilities(66)(13)Trade payables(1,429)(1,252)Other liabilities(13)306Interest received35351Interest paid—(1)Cash flows used in operating activities(13,300)(20,283)Investing activities Purchase of plant and equipment—(9)Proceeds from sale of financial assets10,000—Cash flows used in investing activities10,000(9)Financing activities Proceeds from the issuance of common shares—25,000Capital raising costs—(2,095)Proceeds from exercise of share options—542Payment of lease liabilities(28)(47)Cash flows provided by financing activities(28)23,400Net increase in cash and cash equivalents(3,328)3,109Cash and cash equivalents at the beginning of period18,56226,555Effect of exchange rate fluctuation on cash held38(82)Cash and cash equivalents at end of period15,27229,582 The accompanying notes are an integral part of these condensed interim financial statements. About Vivoryon Therapeutics N.V.Vivoryon is a clinical stage biotechnology company focused on developing innovative small molecule-based medicines. Driven by its passion for ground-breaking science and innovation, the Company strives to change the lives of patients in need suffering from severe diseases. The Company leverages its in-depth expertise in understanding post-translational modifications to develop medicines that modulate the activity and stability of proteins which are altered in disease settings. The Company has established a pipeline of orally available small molecule inhibitors for various indications including Alzheimer’s disease, inflammatory and fibrotic disorders, including of the kidney, and cancer. www.vivoryon.com. Vivoryon Forward Looking StatementsThis press release includes forward-looking statements, including, without limitation, those regarding the business strategy, management plans and objectives for future operations of Vivoryon Therapeutics N.V. (the “Company”), estimates and projections with respect to the market for the Company’s products and forecasts and statements as to when the Company’s products may be available. Words such as “anticipate,” “believe,” “estimate,” “expect,” “forecast,” “intend,” “may,” “plan,” “project,” “predict,” “should” and “will” and similar expressions as they relate to the Company are intended to identify such forward-looking statements. These forward-looking statements are not guarantees of future performance; rather they are based on the Management’s current expectations and assumptions about future events and trends, the economy and other future conditions. The forward-looking statements involve a number of known and unknown risks and uncertainties. These risks and uncertainties and other factors could materially adversely affect the outcome and financial effects of the plans and events described herein. The Company’s results of operations, cash needs, financial condition, liquidity, prospects, future transactions, strategies or events may differ materially from those expressed or implied in such forward-looking statements and from expectations. As a result, no undue reliance should be placed on such forward-looking statements. This press release does not contain risk factors. Certain risk factors that may affect the Company’s future financial results are discussed in the published annual financial statements of the Company. This press release, including any forward-looking statements, speaks only as of the date of this press release. The Company does not assume any obligation to update any information or forward-looking statements contained herein, save for any information required to be disclosed by law. For more information, please contact: Investor ContactVivoryon Therapeutics N.V.Dr. Manuela Bader, Director IR & CommunicationTel: +49 (0)345 555 99 30Email: IR@vivoryon.com Media ContactTrophic CommunicationsValeria FisherTel: +49 175 8041816Email: vivoryon@trophic.eu 1Estimated glomerular filtration rate (eGFR), a validated measure of kidney function, was calculated as a slope analysis across two years taking all available data into account.2Diabetes subgroup defined as patients having at baseline either medical history of diabetes (type 1 or 2) and/or comedication with drugs used in diabetes and/or untreated with an HbA1c > 6.5%.3The timing and execution of the planned Phase 2 study is subject to additional funding / partnership.4Treatment effect – the between-group difference in eGFR slope between varoglutamstat and placebo. Attachment 240912_VVY_H1 2024