BMP2 x ALP x RUNX2

Last update 08 May 2025

Basic Info

Related Targets

BMP2ALPRUNX2

Drugs associated with BMP2 x ALP x RUNX2

Oxy-133

Target

ALP x BMP2 x RUNX2

Mechanism

ALP modulators [+2]

Active Org.

MAX BioPharma, Inc.

Originator Org.

MAX BioPharma, Inc.

Active Indication

Bone Diseases

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with BMP2 x ALP x RUNX2

100 Translational Medicine associated with BMP2 x ALP x RUNX2

0 Patents (Medical) associated with BMP2 x ALP x RUNX2

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Literatures (Medical) associated with BMP2 x ALP x RUNX2

01 Dec 2025·Journal of Orthopaedics

Aqueous extract of Ormocarpum cochinchinense augments proliferation and promotes osteogenesis in osteoblast like MG63 cells

Article

Author: Mani, Krishna Priya ; Vincent, Preethi

BackgroundBone tissue engineering requires a high restorative index as a demand from modern day requirements. Therapeutic agents derived from natural sources play a vital role as modulators in promoting bone regeneration. Ormocarpum cochinchinense, a shrub, is used by the traditional healers of southern East Asia to treat bone fractures. However, there remains a dearth in the exploration of its bone healing properties.MethodsThe present study reports a systematic analysis of the aqueous extract of Ormocarpum cochinchinense (OCE) as a repository of natural bio-actives capable of eliciting in vitro biomineralization and thereby osteogenesis. MTT assay, and Live/dead cell staining assay were used to evaluate the cell viability of MG-63 cells. Alizarin staining evaluated the mineralization by OCE, and ALP enzyme activity was measured both qualitatively and quantitatively. Gene expression of osteogenic markers (Runx2, ALP, Collagen type 1, BMP2, Osteocalcin, and Osteopontin) was measured by RT-qPCR.ResultsThe MTT, and Live/Dead staining results exemplified significant proliferation index. Augmented biomineralization as early as 7 days was validated by Alizarin Red staining with increased mineralized nodules. The activity of Alkaline phosphatase (an early bone marker) was significantly enhanced by OCE. Furthermore, the expression levels of early and late osteogenic markers were increased profoundly after OCE treatment in a dose-dependent manner.ConclusionThe present study demonstrates the potential of Ormocarpum cochinchinense to promote osteogenesis, exemplifying its potential for bone tissue engineering.

01 Jun 2025·Journal of Dentistry

Biocompatibility and periodontal regenerative potential of hydroxyapatite nanoparticles from Portunus Sanguinolentus Shells: A crystallographic, morphological, and molecular gene expression analysis

Article

Author: Sharon V, Maria ; Malaiappan, Sankari

OBJECTIVESThis study aims to extract and characterize hydroxyapatite (HAp) nanoparticles from the exoskeleton of Portunus sanguinolentus (blood-spotted swimming crab) shells for potential biomedical applications, particularly in bone tissue engineering and periodontal regenerative dentistry.MATERIALS AND METHODSCrab shells were cleaned, dried at 100 °C, and ground into powder. The powder was sintered at 1000 °C to obtain calcium carbonate (CaCO₃), which was then reacted with diammonium hydrogen phosphate [(NH₄)₂HPO₄]. in double-distilled water using a wet chemical method at pH >9. The precipitate was filtered, dried at 100 °C, and sintered at 800 °C to synthesize HAp nanoparticles. Characterization using FTIR, EDX, XRD, and SEM confirmed the nanoparticles' chemical composition, crystallinity, and nanoscale morphology. Biocompatibility was evaluated through MTT and live/dead cell assays on human gingival fibroblasts (HGF) and periodontal ligament fibroblasts (HPDLF). Osteogenic potential was assessed via real-time qPCR for ALP, BMP2, and RUNX2 gene expression and Alizarin Red S staining for calcium mineralization. Statistical analysis was conducted using ANOVA with Tukey's test.CONCLUSIONResults demonstrated that crab shell-derived HAp nanoparticles exhibited excellent crystallinity, biocompatibility, and osteogenic potential. Enhanced cell viability and significant upregulation of osteogenic markers confirmed their role in periodontal bone regeneration. Increased calcium deposition further validated their extracellular matrix mineralization capability. These findings suggest that Portunus sanguinolentus-derived HAp nanoparticles are a promising, sustainable biomaterial for periodontal regenerative applications.CLINICAL SIGNIFICANCEThe use of Portunus sanguinolentus-derived hydroxyapatite presents a sustainable and cost-effective alternative to synthetic biomaterials in dental applications. With excellent biocompatibility and the ability to promote osteogenic differentiation, these nanoparticles hold promise for bone grafting, implant coatings, and periodontal regeneration, supporting eco-friendly and efficient solutions for clinical bone repair and regenerative dentistry.

01 May 2025·Biomedical Materials

Osteogenic function of BMP2-modified PEEK scaffolds for orbital fracture repair

Article

Author: Wang, Wenwen ; Liu, Honglei ; Liu, Jinhua ; Wu, Yujie ; Qin, Bixuan ; Liu, Cuihong

AbstractThis study aimed to investigate the osteogenic function of polyetheretherketone (PEEK) scaffolds modified with bone morphogenetic protein 2 (BMP2) and its possibility for orbital fracture repair. The 3D-printed PEEK sheets were combined with BMP2-loaded hyaluronic acid hydrogel (HAH) to fabricate PEEK-BMP2-HAH composite scaffolds. Bone marrow mesenchymal stem cells (BMSCs) were seeded onto PEEK or PEEK-BMP2-HAH scaffolds. Cell adhesion and cell proliferation were measured by transmission electron microscopy and CCK-8 assay. Alkaline phosphatase (ALP) chromogenic, alizarine red S staining, and PCR analysis of Runt-related transcription factor 2 (Runx2), collagen-I (Col-I), Osterix, and osteopontin (OPN) were performed to assess osteogenic activity. The rat orbital fracture defect model is proposed for evaluating the biocompatibility, osteogenic integration, and functional recovery of PEEK orbital implants. Compared with PEEK, cell adhesion and cell proliferation were increased in PEEK-BMP2-HAH scaffolds. ALP activity and mineralized nodule formation were increased in PEEK-BMP2-HAH scaffolds than that in PEEK the mRNA expression of Runx2, Osterix, Col-I and OPN was increased on PEEK-BMP2-HAH scaffolds than that on PEEK at 14 d of osteogenic induction. Besides, a bone defect animal model revealed that BMP2-HAH-modified PEEK scaffolds could effectively facilitate the repair of the orbital bone defect, with increased expression of OPN and Runx2. BMP2-loaded HAH effectively increased adhesion, proliferation, and osteogenic differentiation of BMSCs on PEEK. PEEK-BMP2-HAH scaffolds are expected to become new materials for orbital fracture repair.

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