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Last update 23 Jan 2025

mEH

Last update 23 Jan 2025

Basic Info

Synonyms

EPHX, EPHX1, EPOX

+ [4]

Introduction

Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911).

Drugs associated with mEH

JP2023011148

Patent Mining

Target

mEH

Mechanism-

Active Org.

Saga University

Originator Org.

Saga University

Active Indication

Cardiovascular Diseases

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with mEH

100 Translational Medicine associated with mEH

0 Patents (Medical) associated with mEH

1,255

Literatures (Medical) associated with mEH

01 Feb 2025·Life Sciences

NVP-AUY922 relieves radiation-induced intestinal injury via regulating EPHX1

Article

Author: Kong, Wenzhe ; Wang, Zhaoyu ; Fan, Saijun ; Lu, Lu ; Ding, Xudong

As a common side effect of radiotherapy, radiation-induced intestinal injury (RIII) greatly affects the prognosis of patients and the efficacy of radiotherapy. Current therapeutic strategies for RIII are still very limited. Thus, the identification of effective radioprotective agents is of great importance. NVP-AUY922 is an HSP90 inhibitor with favorable anti-inflammatory and antioxidant activities. It has been proven to mitigate radiation-induced lung injury. However, its effects on the alleviation of RIII remain unclear. In this study, our data indicated that NVP-AUY922 remarkably increased the survival rate after radiation exposure. NVP-AUY922 treatment could enhance the viability of intestinal stem cells (ISCs) and promote the recovery of the small intestine. In addition, it also inhibited intestinal inflammation and reshaped the gut microbiota structure. We found that the radioprotective effect of NVP-AUY922 is partially dependent on EPHX1. In addition, NVP-AUY922 could attenuate dextran sulfate sodium (DSS)-induced colitis and promote intestinal barrier recovery. Thus, our results suggest that NVP-AUY922 contributes to the amelioration of intestinal injury after radiation exposure, which offers a new approach for the prevention of RIII.

15 Jan 2025·The Journal of Maternal-Fetal & Neonatal MedicineQ4 · MEDICINE

Oxidative stress-related genes ( EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis

Q4 · MEDICINE

Article

Author: Liu, Jing ; Meng, Tao ; Zhao, Ge

BACKGROUNDPrevious studies have detected the association of polymorphisms in oxidative stress-related genes EPHX1 and MnSOD with pre-eclampsia (PE) risk, but the results are inconsistent among studies. Thus, a meta-analysis was performed to obtain more conclusive results.METHODSEligible studies were retrieved in PubMed, Web of Science, EMBASE, Scopus, and CNKI. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between EPHX1 rs1051740, EPHX1 rs2234922, MnSOD rs4880 polymorphisms, and PE susceptibility in the genetic models. The subgroup analysis was also performed.RESULTSFourteen studies with a total of 4250 participants were included, including 1784 PE patients and 2466 healthy women. There was a statistically significant association between EPHX1 rs1051740 polymorphism and PE in Caucasians within the allele, dominant, heterozygous, and homozygous models (OR = 0.79, 95% CI = 0.64-0.98; OR = 0.64, 95% CI = 0.47-0.87; OR = 0.61, 95% CI = 0.44-0.85; OR = 0.63, 95% CI = 0.42-0.97, respectively). There was a statistically significant association between EPHX1 rs2234922 polymorphism and PE in Middle Easterners within the recessive and homozygous models (OR = 3.59, 95% CI = 1.25-10.32; OR = 3.99, 95% CI = 1.38-11.49, respectively). There was no statistically significant association between MnSOD rs4880 polymorphism and PE within five genetic models. Subgroup analysis didn't reveal any association between MnSOD rs4880 polymorphism and PE in Asians, Caucasians, or Middle Easterners.CONCLUSIONSThis meta-analysis shows a significant association between the EPHX1 rs1051740 and PE risk in Caucasians. Meantime, there was a statistically significant association between EPHX1 rs2234922 polymorphism and PE in Middle Easterners.

10 Dec 2024·Analytical Chemistry

Strategies for the Immobilization and Signal Amplification of a Double Nanobody Sandwich ELISA for Human Microsomal Epoxide Hydrolase

Article

Author: Morisseau, Christophe ; Pan, Bofeng ; McCoy, Mark ; Pan, Junkang ; Li, Dongyang ; He, Qiyi ; Xu, Zhihao ; Hammock, Bruce D. ; Sun, Gang

The microsomal epoxide hydrolase (mEH) is important in the detoxification of carcinogens in the liver and other tissues but is also a blood biomarker of hepatitis and liver cancer. Improved analytical methods are needed for the study of its role in the metabolism of xenobiotics and endogenous roles as a blood biomarker of diseases. The development of a double nanobody sandwich ELISA offers significant improvements over traditional polyclonal or monoclonal antibody-based assays, enhancing both the homogeneity and the stability of assay production. This study focuses on selecting and optimizing nanobody pairs for detecting human mEH. Four high-affinity nanobodies were identified and tested for thermal stability. Combinations of these nanobodies were evaluated, revealing that the MQ4-MQ30 pair achieved the best performance with a limit of detection (LOD) of 1 ng/mL. Additionally, polyHRP was also employed for signal amplification, enhancing detection capabilities despite challenges related to the small size and single epitope recognition of the nanobodies. Comparative studies using microplates and NHS@MF membranes were also performed. The superior performance of the NHS@MF membranes highlighted their potential as a promising alternative for point-of-care testing. The assay exhibited high specificity for human mEH and minimal cross-reactivity with related enzymes and effectively addressed matrix effects in plasma and tissue samples. These findings underscore the potential of double nanobody sandwich ELISAs for reliable and sensitive biomarker detection.

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mEH

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