Last update 01 Nov 2024

TLR4 x CD14

Last update 01 Nov 2024

Basic Info

Related Targets

TLR4CD14

Drugs associated with TLR4 x CD14

IAXO-101

Target

CD14 x TLR4

Mechanism

CD14 inhibitors [+1]

Active Org.

Innaxon Therapeutics

Originator Org.

Innaxon Therapeutics

Active Indication

Inflammation

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

IAXO-103

Target

CD14 x TLR4

Mechanism

CD14 inhibitors [+1]

Active Org.-

Originator Org.

Innaxon Therapeutics

Active Indication-

Inactive Indication

Inflammation

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with TLR4 x CD14

100 Translational Medicine associated with TLR4 x CD14

0 Patents (Medical) associated with TLR4 x CD14

2,083

Literatures (Medical) associated with TLR4 x CD14

01 Jan 2025·Food Chemistry

Enhanced anti-inflammatory effect of fish myofibrillar protein by introducing pectin oligosaccharide and its molecular mechanisms

Article

Author: Li, Wenzhao ; Yang, Boxue ; Joe, Ga-Hyun ; Saeki, Hiroki ; Shimizu, Yutaka

This study investigated the efficacy of glycation with edible uronic acid-containing oligosaccharides via the Maillard reaction to enhance the anti-inflammatory effect of fish myofibrillar protein (Mf). Lyophilized Mf was reacted with pectin oligosaccharide (PO, half of the total protein weight) at 60 °C and 35 % relative humidity for up to 12 h to produce glycated Mf (Mf-PO). After pepsin and trypsin digestion, the anti-inflammatory effect was assessed by measuring the secretions of proinflammatory cytokines in LPS-stimulated RAW 264.7 macrophages, and the anti-inflammatory effect of Mf was enhanced by PO-glycation without marked lysine loss and browning. The effects on the expressions of genes related to the LPS-stimulated signaling pathway in macrophages were also examined. PO-glycation suppressed LPS-stimulated inflammation by suppressing expression of cd14 and enhancing suppressive effect of Mf on the TLR4-MyD88-dependent inflammatory signaling pathway. Therefore, as an edible reducing sugar, PO could be an effective bioindustrial material for developing anti-inflammatory Mf.

01 Dec 2024·Cellular and Molecular Life Sciences

Correction: Flotillins affect LPS-induced TLR4 signaling by modulating the trafficking and abundance of CD14

Author: Traczyk, Gabriela ; Matveichuk, Orest V ; Hromada-Judycka, Aneta ; Nowak, Natalia ; Ciesielska, Anna ; Ben Amor, Ichrak ; Kwiatkowska, Katarzyna

01 Dec 2024·Tissue and Cell

Effects of tea tree oil and cefepime treatments on morphological, genetic, histopathological, immunohistochemistry, and biochemical assessments in liver and kidney of Escherichia coli infected rats

Article

Author: Altohamy, Dalia E. ; Ali, Amer Al ; Altohamy, Dalia E ; Mahboub, Heba H. ; Elmani, Taghreed ; Aref, Mohamed ; Ezz-Eldin, Rasha M.M. ; Heikal, Hanim S ; Ezz-Eldin, Rasha M M ; Abdelazim, Aaser M ; Mansour, Abdallah Tageldein ; Mahboub, Heba H ; Sobh, Mohammed S ; Sobh, Mohammed S.

The current study evaluated the influence of the treatment with tea tree oil and cefepime on morpho- genetic, histo-immunohistochemical, and biochemical assessments in rats experimentally challenged with Escherichia coli ATCC 4157™. Thirty adult male rats were divided into control, E. coli infected positive group (1×108CFU/I/P/once), E. coli with cefepime-supplemented group (45 mg/kg bw/I/M/day), E. coli with tea tree oil treated group (1.5 ml/per os/day), and the E. coli-challenged group that received a combination of tea tree oil and cefepime. E. coli infection induced morphological changes in color and texture of both liver and kidney. The transcription levels of the PHLPP2 and Nrf2 genes were noticeably lowered in all treated groups related to the E. coli group. Regarding the TLR4 expression, it was clearly up-regulated in the E. coli group in comparison to other groups, while CD14 gene decreased clearly in all treated groups compared to the positive group. The findings revealed that RBC, HGB, and PCV were clearly higher in the positive group compared to all treated groups. AST, ALT, and ALP, total bilirubin and its fractions, urea, and creatinine maximized in the positive group and decreased by the treatment, especially in the E+CF+oil treated group. Regarding the redox balance, MDA levels of MDA were notably reduced in the E+CF+oil treated group compared to the positive and the other treated groups. GSH, SOD, and GPX were significantly induced in the E. coil-treated group and decreased significantly with treatment. Overall, cefepime is highly safe especially when dually supplied with tea tree oil for mitigating E. coli adverse impact.

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