PARP7

BEIJING, SHANGHAI, and SAN DIEGO, April 9, 2024 /PRNewswire/ -- Jacobin Pharma (1167.HK), a clinical-stage oncology company focusing on undruggable targets, today announced that the company will present the results of two preclinical evaluation of PARP7 inhibitor JAB-26766 and p53 Y220C reactivator JAB-30355 in form of the abstract during the American Association for Cancer Research (AACR) Annual Meeting 2024 (the "AACR 2024") from April 5 to 10, 2024. Dr. Andrea Wang-Gillam, Chief Medical Officer and Global Head of R&D of Jacobio Pharma, said: " The preclinical data of the two drugs are representatives of our continued efforts in developing drugs toward key oncogenic pathways. P53 Y220C is the first tumor suppressor gene to enter into clinical study and has the potential to be used in combination with chemotherapy or oncogenic protein inhibitors. As an important downstream target of the STING signaling pathway, PARP7 is expected to be used in combination with immunotherapy in the future. Jacobio is committed to developing both assets globally." Details for the 2024 AACR abstracts are as follows: JAB-26766: a small-molecule, orally bioavailable PARP7 inhibitor with high potency and selectivity Poster Presentation: April 9, 2024, 9:00 AM - 12:30 PM (GMT-7) Session: PO.ET09.01 - DNA Reactive Agents JAB-26766 is a potent, orally bioavailable PARP7 inhibitor with >1800-fold selectivity on PARP7 over PARP2. JAB-26766 as a single agent shows potent in vivo anti-tumor activities, which can be further enhanced through combination with STING agonist or anti-PD-1 mAb. JAB-30355: A highly potent, orally bioavailable p53 Y220C reactivator Poster Presentation: April 9, 2024, 1:30 PM - 5:00 PM (GMT-7) Session: PO.ET09.09 - Novel Antitumor Agents 4 JAB-30355 is a potent and selective p53 Y220C reactivator. JAB-30355 exhibited dose-dependent anti-tumor activity, inducing tumor stasis or regression in multiple CDX and PDX models of ovarian cancer, pancreatic cancer, gastric cancer, and small cell lung cancer, with overall good tolerability. A phase I/IIa clinical trial to evaluate the safety and efficacy of JAB-30355 in patients with advanced solid tumor is ongoing in U.S. The 2024 AACR Annual Meeting will be held in San Diego, California, U.S. from April 5th to April 10th. For more information, please visit the official website of the AACR: About Jacobio Jacobio Pharma (1167.HK) is committed to developing and providing new and innovative products and solutions to improve people's health. Our pipeline revolves around novel molecular targets on six major signalling pathways: KRAS, immune checkpoints, tumor metabolism, P53, RB and MYC. We aim for our key projects to be among the top three in the world. Our vision is to become a global leader recognized for our impact in drug R&D together with our partners. Jacobio has R&D centers in Beijing, Shanghai and Boston with our Induced Allosteric Drug Discovery Platform (IADDP) and our iADC Platform. SOURCE Jacobio Pharma

BEIJING, SHANGHAI and BOSTON, March 28, 2024 Jacobio/PRNewswire/ -- Pharma (1167.HK), a clinical-stage oncology company drugging the undruggable targets, today announced its 2023 annual results. The revenue was RMB63.5 million, the R&D investment was RMB372 million, the cash and cash equivalent at the end of 2023 was RMB 1.2 billion. Jacobio Pharma also announced its recent business progress and expected milestones. Dr. Wang Yinxiang, Chairman and CEO of Jacobio Pharma, said: "In the past year, Jacobio continued to make progress in our projects. We received approval for registrational phase III clinical trial of the combination therapy between our SHP2 inhibitor JAB-3312 and KRAS G12C inhibitor glecirasib. Our JAB-3312 became the first SHP2 inhibitor to enter into registrational trial. This milestone is consistent with our mission of 'drugging the undruggable'. Meanwhile, the patient enrollment for pivotal trial of our core product glecirasib has been completed, and the NDA application expected to be submitted in the first half of 2024. This marks that Jacobio will enter into the commercial stage." Development of core clinical stage products KRAS G12C inhibitor Glecirasib (JAB-21822) Non-small cell lung cancer (NSCLC) The patient enrollment for pivotal trial of glecirasib monotherapy in ≥2L NSCLC patients harboring KRAS G12C mutation was completed. The NDA application is expected to be submitted to CDE (Center for drug evaluation, NMPA) in Q2 2024 as planned. 1L NSCLC is in combination with SHP2 inhibitor JAB-3312. The phase III registrational trial was approved by CDE. Pancreatic cancer (PDAC) The pivotal trial of glecirasib monotherapy in ≥2L PDAC patients was activated in China. The results were presented at the 2024 American Society of Clinical Oncology (ASCO) GI Annual Meeting. The cORR was 41.9% (13/31) and the DCR was 93.5% (29/31). The median progression-free survival (mPFS) was 5.6 months. Colorectal cancer (CRC) The clinical results of glecirasib monotherapy and glecirasib combined with cetuximab in advanced colorectal cancer were presented at the Second JCA- AACR Precision Medicine International Conference. Phase III pivotal trial design of glecirasib monotherapy or glecirasib in combination with cetuximab is expected to be approved by CDE in Q2 2024. Multi-tumors basket Multi-tumors basket includes biliary tract cancer, gastric cancer, small bowel cancer, appendices cancer, etc. The results were presented at the 2024 American Society of Clinical Oncology (ASCO) GI Annual Meeting. The cORR was 57.9%（11/19), DCR was 84.2%（16/19), mPFS was 7.0 months. A phase II single arm pivotal trial is under communication with CDE. SHP2 inhibitor JAB-3312 The Phase III pivotal trial of JAB-3312 in combination with glecirasib to treat 1L NSCLC patients has been approved by CDE, and this study in China is expected to initiated in Q3 2024. JAB-3312 is the very first SHP2 inhibitor entering a phase III registrational trial worldwide. The clinical data of glecirasib in combination with JAB-3312 was published at the 2023 European Society for Medical Oncology Congress (ESMO 2023). Glecirasib (800mg once daily) + JAB-3312 2mg (once daily for 1 week on, then 1 week off) dosage yielded ORR of 86.7% (13/15) and DCR of 100% (15/15). Long term safety and efficacy data have submitted to the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting. Development of other clinical products P53 Y220C activator JAB-30355: The IND has been approved by U.S. FDA (Food and Drug Administration), and phase I clinical trial is expected to be initiated in the second half of 2024. Preclinical data will be presented at the AACR Annual Meeting 2024. BET inhibitor JAB-8263: A Phase II trial of JAB-8263 monotherapy or combination therapies is planned to be initiated in the second half of 2024. Clinical data will be published at the 2024 European Hematology Association (EHA) Congress. Aurora A inhibitor JAB-2485: RP2D is anticipated to be determined in Q2 2024. The preclinical study of JAB-2485 was presented at the 2023 AACR. Anti-CD73 humanized monoclonal antibody JAB-BX102: RP2D is anticipated to be determined in Q2 2024. The preclinical study of JAB-2485 was presented at the 2023 AACR. PARP7 inhibitor JAB-26766: Preclinical data will be presented at the AACR Annual Meeting 2024. We are optimizing the clinical development strategy for PARP7 inhibitor JAB-26766, GUE (glutamine-utilizing enzyme) inhibitor JAB-24114, and LIF mAb JAB-BX300 considering the current treatment landscape and our resources available. Development of other pre-clinical products KRASmulti inhibitor JAB-23E73: The IND application is expected to be submitted in Q2 2024. Clinical candidate for HER2-STING iADC JAB-BX400 is expected to be nominated in the second half of 2024. As of December 31, 2023, Jacobio owned 340 patents or patent applications that are filed globally, of which 82 patents have been issued or allowed in major markets globally. During the performance period, Jacobio raised HKD159 million through public placing, and obtained RMB150 million from Beijing E-town Capital. As of December 31, 2023, Jacobio has RMB 1.2 billion cash and cash equivalent, providing sufficient cash reserves for R&D investment in the next 30-36 months. Jacobio repurchased and canceled 1.807 million shares, continuing to increase shareholder value. Conference Call Information Jacobio Pharma will hold a live conference call at 10:30 AM March 29 2024 Beijing time. Participants please register in advance through . About Jacobio Jacobio Pharma (1167.HK) is committed to developing and providing new and innovative products and solutions to improve people's health. Our pipeline revolves around novel molecular targets on six major signaling pathways: KRAS, immune checkpoints, tumor metabolism, P53, RB and MYC. We aim for our key projects to be among the top three in the world. Our vision is to become a global leader recognized for our impact in drug R&D together with our partners. Jacobio has R&D centers in Beijing, Shanghai and Boston with our Induced Allosteric Drug Discovery Platform (IADDP) and our iADC Platform. SOURCE Jacobio Pharma

OR YEHUDA, Israel, May 15, 2023 /PRNewswire/ -- Peregrine Ventures, Israel's leading investment firm dedicated to supporting life changing healthcare opportunities, today celebrated the transformative accomplishments of their high-performing portfolio of medical technology companies. The Q1 2023 portfolio achievement highlights include a $25 million equity investment from Pfizer, entering a clinical trial agreement with Merck & Co, and the successful preliminary results of its first-in-human clinical study. "Peregrine prides itself on its ability to identify and invest in first-in-class and best-in-class healthcare companies," said Eyal Lifschitz, Managing Partner and Co-founder of Peregrine Ventures. "These accomplishments are the truest example of why our work is important, and we are proud to be a part of these companies' success stories. We look forward to seeing their future accomplishments on the path to becoming widely accessed, game-changing global healthcare opportunities." Q1 2023 achievements include: BioProtect, a technology platform company that provides innovative bioabsorbable spacers, realized successful Phase I/II clinical study results of company's BioProtect Balloon Implant System. In treating rectal toxicity that is often a result of prostate cancer radiation therapy, the balloon spacer is safe, does not affect patient quality of life, and preserves local control in patients with intermediate-high risk. EndoStream Medical enrolled the first patient in the company's U.S. clinical trial to evaluate the Nautilus™ Intrasaccular System, a revolutionary technology for the treatment of cerebral aneurysms. The Nautilus is a self-conforming intrasaccular flow diverter, maximizing neck coverage and enhancing coil stability, to optimize intrasaccular thrombosis and enable progressive occlusion of the aneurysm. The medical technology was also featured on the cover of Interventional Neuroradiology (INR). Levation Pharma, a pharmaceutical company focused on the development of new therapeutics for the ophthalmology and aesthetic space, received FDA clearance to initiate Phase I and II of LEV102, a proprietary aqueous gel. The clinical trial is designed to determine the preliminary safety and efficacy signals for LEV102 as a potential treatment for drooping of the upper eye lid, Acquired Blepharoptosis, in adults. Nectin Therapeutics, a biotechnology company developing novel targeted immunotherapies that address resistance to approved immune oncology treatments, entered a clinical trial agreement with Merck & Co. The trail will assess the safety and efficiency of Nectin's first-in-class anti-PVR treatment as it is used in combination with Merck's anti-PD1 therapy, KEYTRUDA® for the treatment of metastatic solid tumors. Restore Medical saw successful preliminary results of its first-in-human clinical study of the CONTRABAND™ system, the world's first and only Pulmonary Artery Banding transcatheter implant designed to treat left ventricle failure by restoring the heart's efficient structure. The six-month and one-year results of the study demonstrated that the implantation procedure of the CONTRABAND™ device was safe for all participants and improved the quality of life for those treated. Ribon Therapeutics, a clinical-stage biotechnology company developing therapeutics to target stress support pathways, received a $25 million equity investment from Pfizer. This additional funding will support the clinical development of Ribon's potentially first-in-class oral small molecule programs in oncology (RBN-2397, a PARP7 inhibitor) and immunology (RBN-3143, a PARP14 inhibitor). Ribon Therapeutics also announced the dosing of the first patient in the open-label cohort of patients with moderate-to-severe atopic dermatitis. This testing is part of the company's Phase 1 clinical study of RBN-3143, a first-in-class, oral small molecule inhibitor of PARP14, for the treatment of a range of inflammatory diseases. In addition to these portfolio achievements, Peregrine Ventures has made several new investments in early- and seed-stage companies in the bio-convergence field for incubation in their world-class MedTech incubator. Companies include: OncoRedox, a point-of-care testing device that utilizes AI to detect cancer from urine samples; CTC Therapeutics, an innovative technology for collecting tumor cells which applies a unique manipulation to activate an immune response to attack the cancer cells; EViCure, a unique off-the-shelf anti-tumor exosome treatment that exerts anti-tumor effects; and MilCo, a food tech startup that aims to produce animal-free dairy products by producing functional milk proteins in yeast. DairyX products will be healthier and more accessible with the same taste and cost of traditional dairy products. ABOUT PEREGRINE VENTURES Peregrine Ventures, Israel's first dedicated healthcare fund, is committed to improving patients' quality of life by investing in and supporting game-changing healthcare opportunities. As a leading global life science venture capital fund, Peregrine invests throughout a company's life cycle to help facilitate growth and success and offers creative business solutions to suit the needs of its portfolio companies. From seed-stage opportunities to more mature companies, Peregrine's specifically defined funds offer portfolio companies complete, end-to-end investment solutions that have helped bring healthcare innovations to fruition for over 20 years. Peregrine's robust portfolio includes fast growing global companies, in the fields of biotech, medical devices, and digital health. Peregrine's mature funds maintain their strong position in the upper quartile of the industry's leading benchmarks (Number of exits, DPI, IRR, etc.). For more information, please visit . CONTACT: SARA KLEIN, 212-805-3018 [email protected] SOURCE Peregrine Ventures