Last update 01 Nov 2024

ELDR x HERs

Last update 01 Nov 2024

Basic Info

Related Targets

ELDRHERs

Drugs associated with ELDR x HERs

CN115819606

Patent Mining

Target

ELDR x HERs

Mechanism-

Active Org.

Jiangnan University

Originator Org.

Jiangnan University

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with ELDR x HERs

100 Translational Medicine associated with ELDR x HERs

0 Patents (Medical) associated with ELDR x HERs

Literatures (Medical) associated with ELDR x HERs

01 Jun 2022·The FEBS JournalQ3 · BIOLOGY

Emerging role of lncRNA ELDR in development and cancer

Q3 · BIOLOGY

Review

Author: Sur, Subhayan ; Ray, Ratna B.

Whole‐genome sequencing and transcriptome analysis revealed more than 90% of the human genome transcribes noncoding RNAs including lncRNAs. From the beginning of the 21st century, lncRNAs have gained widespread attention as a new layer of regulation in biological processes. lncRNAs are > 200 nucleotides in size, transcribed by RNA polymerase II, and share many similarities with mRNAs. lncRNA interacts with DNA, RNA, protein, and miRNAs, thereby regulating many biological processes. In this review, we have focused mainly on LINC01156 [also known as the EGFR long non‐coding downstream RNA (ELDR) or Fabl] and its biological importance. ELDR is a newly identified lncRNA and first reported in a mouse model, but it has a human homolog. The human ELDR gene is closely localized downstream of epidermal growth factor receptor (EGFR) gene at chromosome 7 on the opposite strand. ELDR is highly expressed in neuronal stem cells and associated with neuronal differentiation and mouse brain development. ELDR is upregulated in head and neck cancer, suggesting its role as an oncogene and its importance in prognosis and therapy. Publicly available RNA‐seq data further support its oncogenic potential in different cancers. Here, we summarize all the aspects of ELDR in development and cancer, highlighting its future perspectives in the context of mechanism.

03 Dec 2020·EMBO reportsQ1 · BIOLOGY

Long non‐coding RNA ELDR enhances oral cancer growth by promoting ILF3‐cyclin E1 signaling

Q1 · BIOLOGY

Article

Author: Sur, Subhayan ; Ray, Ratna B ; Zhang, Dapeng ; Nakanishi, Hiroshi ; Varvares, Mark A ; Steele, Robert

AbstractOral squamous cell carcinoma (OSCC) is the sixth most common cancer with a 5‐year overall survival rate of 50%. Thus, there is a critical need to understand the disease process, and to identify improved therapeutic strategies. Previously, we found the long non‐coding RNA (lncRNA) EGFR long non‐coding downstream RNA (ELDR) induced in a mouse tongue cancer model; however, its functional role in human oral cancer remained unknown. Here, we show that ELDR is highly expressed in OSCC patient samples and in cell lines. Overexpression of ELDR in normal non‐tumorigenic oral keratinocytes induces cell proliferation, colony formation, and PCNA expression. We also show that ELDR depletion reduces OSCC cell proliferation and PCNA expression. Proteomics data identifies the RNA binding protein ILF3 as an interacting partner of ELDR. We further show that the ELDR‐ILF3 axis regulates Cyclin E1 expression and phosphorylation of the retinoblastoma (RB) protein. Intratumoral injection of ELDR‐specific siRNA reduces OSCC and PDX tumor growth in mice. These findings provide molecular insight into the role of ELDR in oral cancer and demonstrate that targeting ELDR has promising therapeutic potential.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis