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Last update 23 Jan 2025

Prostanoid receptor x NF-κB x TNF-α

Last update 23 Jan 2025

Basic Info

Related Targets

Prostanoid receptorNF-κBTNF-α

Drugs associated with Prostanoid receptor x NF-κB x TNF-α

RPL-228

Target

NF-κB x Prostanoid receptor x TNF-α

Mechanism

NF-κB inhibitors [+2]

Active Org.-

Originator Org.

Rosanto Pharmaceuticals Ltd.

Active Indication-

Inactive Indication

Psoriasis

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

RPL-208

Target

NF-κB x Prostanoid receptor x TNF-α

Mechanism

NF-κB inhibitors [+2]

Active Org.-

Originator Org.

Rosanto Pharmaceuticals Ltd.

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Prostanoid receptor x NF-κB x TNF-α

100 Translational Medicine associated with Prostanoid receptor x NF-κB x TNF-α

0 Patents (Medical) associated with Prostanoid receptor x NF-κB x TNF-α

Literatures (Medical) associated with Prostanoid receptor x NF-κB x TNF-α

01 Dec 2024·Molecular Nutrition & Food Research

Lactobacillus fermentum MCC2760 Attenuates Heated Oil‐Induced Brain Oxidative Stress and Inflammation via Modulation of NRF2 and NF‐kB in Rats

Article

Author: Uppin, Vinayak ; Halami, Prakash ; Yashwanthkumar, Manasa Hassan ; Talahalli, Ramaprasad Ravichandra ; Keremane, Vyshali Ramesh

ScopeReusing deep‐fried oil is a common practice to cut costs, and their consumption may affect brain function. Hence, the study investigates the modulatory potential of Lactobacillus fermentum MCC2760 (LF) on heated oil‐induced brain oxidative stress (OS) and inflammation that may have a bearing on cognition in experimental rats.Methods and resultsFemale Wistar rats are fed with diets containing native sunflower oil (N‐SFO), native canola oil (N‐CNO), heated sunflower oil (H‐SFO), heated canola oil (H‐CNO), heated sunflower oil with probiotic (H‐SFO + LF), or heated canola oil with probiotic (H‐CNO + LF} for 60 days. Compared to respective controls, heated oils significantly (p < 0.05) increased OS by decreasing antioxidant defense enzymes and nuclear factor erythroid 2‐related factor 2 (NRF2) activity. Further, heated oil elevates brain expression of cytosolic phospholipase A2 (cPLA2), cyclooxygenase‐2 (COX‐2), prostaglandin‐E receptor 4 (EP‐4), intercellular adhesion molecule 1 (ICAM‐1), nitric oxide synthase 2 (NOS‐2), followed by an increased production of proinflammatory eicosanoids (prostaglandin E2 [PGE2] and leukotriene B4 [LTB4]) and cytokines (tumor necrosis factor‐α [TNF‐α], monocyte chemoattractant protein‐1 [MCP‐1], interleukin‐1β [IL‐1β], and interleukin‐6 [IL‐6]). The increased nuclear translocation of nuclear factor kappa beta (NF‐kB) in heated oil‐fed groups’ brains corroborates the heightened inflammatory response. Heated oils decrease neurotrophins and neuron development markers. However, administration of LF abrogates the heated oil‐induced alterations significantly (p < 0.05).ConclusionsThe present study is novel in demonstrating the protective role of probiotic LF against heated‐oil‐induced brain OS and inflammation in rats.

23 Oct 2024·Journal of Agricultural and Food Chemistry

Enteromorpha prolifera Polysaccharide Alleviates Acute Alcoholic Liver Injury in C57 BL/6 Mice through the Gut–Liver Axis and NF-κB Pathway

Article

Author: Wen, Chengrong ; Zhang, Yuying ; Yang, Jingfeng ; Yan, Tingting ; Sun, Jinghe

Enteromorpha prolifera polysaccharide (EP2) protection against acute alcoholic liver injury (AALI) in mice was investigated. By integration of physiological indicators, gut microbiota, and short-chain fatty acids (SCFAs), the mechanism of EP2 in alleviating AALI was disclosed. The results showed that EP2 significantly ameliorated alcohol-induced abnormal transaminase activities, liver and intestinal systemic inflammation, and intestinal environmental disorders. EP2 significantly reduces liver and serum LPS contents by 1.69-fold and 1.54-fold. Furthermore, inhibition of the NF-κB signaling pathway by EP2 reduced the production of proinflammatory cytokines such as TNF-α (1.83-fold), IL-6 (11.09-fold), and IL-1β (1.99-fold). EP2 restored SCFAs to normal levels by upregulating the abundance of beneficial bacteria (Colidextribacter, Ruminococcus, unclassified_Lachnospiraceae, and Akkermansia). The alleviation of AALI by EP2 occurs through protection of the intestinal mucosal barrier and reduction of LPS permeating in serum. The decrease in LPS inactivates the NF-κB signaling pathway and prevents inflammation. In short, EP2 regulates the gut-liver axis and inflammation, alleviating effects in AALI mice.

01 Nov 2023·Biomedicine & Pharmacotherapy

A new approach for the treatment of bleomycin-induced rat pulmonary injury by combined protein fraction of major royal jelly protein 2 and its isoform X1

Article

Author: Shaban, Nadia Z ; Abu-Serie, Marwa M ; Habashy, Noha H ; Olleak, Shaimaa A

Nowadays, royal jelly (RJ) has gained great interest as a functional food due to its valuable pharmacological effects. We investigated the therapeutic potency of combined protein fraction (PF₅₀) of major RJ protein 2 and its isoform X1 on bleomycin (Bleo)-induced pulmonary injury in rats. Our study examined the impact of PF₅₀ on pulmonary oxidative and inflammatory stress as well as smooth muscle alpha-actin (α-SMA). In addition, the predicted impacts of this PF on the activity of matrix metalloproteinase (MMP)- 8 and 15-prostaglandin dehydrogenase (15-PGDH) and the E-type prostanoid 2 (EP2) and IL-13 α2 subunit (IL13α2R) receptors, were evaluated using molecular docking. The results showed that PF₅₀ reduced pulmonary inflammatory cells and their secreted pro-inflammatory mediators, including NF-κB, IKK, IL-4, IL-6, and NO. Additionally, the levels of IgE and mucin were diminished after treatment with PF₅₀. Moreover, PF₅₀ treatment improved pulmonary oxidative stress indices such as lipid peroxidation, GSH, SOD, and GPX. The histopathological findings, chest conventional X-ray, and immunohistochemistry of α-SMA confirmed the ameliorating effect of PF₅₀. The docking outcomes reported the probable competitive inhibitory influence of PF₅₀ on MMP-8 and a postulated blocking effect on EP2 and IL13α2R. Thus, PF₅₀ could be a novel approach for treating pulmonary injuries.

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