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Last update 23 Jan 2025

CDHR3

Last update 23 Jan 2025

Basic Info

Synonyms

cadherin related family member 3, Cadherin-like protein 28, Cadherin-related family member 3

+ [4]

Introduction

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (Microbial infection) Acts as a receptor for rhinovirus C.

Drugs associated with CDHR3

AT-005 (Arctic Therapeutics)

Target

CDHR3

Mechanism

CDHR3 modulators

Active Org.

Arctic TherapeuticsStartup

Originator Org.

Arctic TherapeuticsStartup

Active Indication

Asthma [+1]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CDHR3

100 Translational Medicine associated with CDHR3

0 Patents (Medical) associated with CDHR3

Literatures (Medical) associated with CDHR3

01 Feb 2025·Placenta

Profiling epithelial viral receptor expression in amniotic membrane and nasal epithelial cells at birth

Article

Author: Renouf, Bailee ; Berry, Luke ; Lim, James ; Sutanto, Erika N ; Stick, Stephen M ; D'Vaz, Nina ; Amin, Minda ; Kicic-Starcevich, Elizabeth ; Hoyne, Gerard F ; Kidd, Courtney ; Iosifidis, Thomas

INTRODUCTIONChildren with wheeze and asthma present with airway epithelial vulnerabilities, such as impaired responses to viral infection. It is postulated that the in utero environment may contribute to the development of airway epithelial vulnerabilities. The aims of the study were to establish whether the receptors for rhinovirus (RV), respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are expressed in the amniotic membrane and whether the pattern of expression is similar to newborn nasal epithelium.METHODSPlacenta were collected (n = 33) from newborns in AERIAL, a sub-study nested under the ORIGINS birth cohort. Using purified RNA from amniotic samples (n = 33), along with previously extracted RNA from nasal epithelial cells from newborns (n = 20), real-time quantitative polymerase chain reaction (qPCR) was performed to determine gene expression of viral receptors for RV, RSV and SARS-CoV-2 in both amniotic and newborn nasal epithelial samples. In addition, receptor protein expression was quantified through Western blot and localised using immunohistochemical staining in amniotic samples.RESULTSAmniotic and newborn nasal samples expressed various receptors for RV (ICAM-1, LDLR, CDHR3), RSV (NCL, CX3CR1) and SARS-CoV-2 (ACE2, TMPRSS2) at the gene level, although the magnitude of expression varied. In addition, protein expression of these receptors was confirmed in the amniotic samples. These proteins were localised to the epithelial layer of the amniotic membrane.CONCLUSIONThis proof-of-concept study indicates the potential of amniotic samples to facilitate investigation into the interactions between the in utero environment and prenatal programming of epithelial innate immune responses to viruses.

01 Dec 2024·Cell Genomics

Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution

Article

Author: Dai, Jiapei ; Yin, Jichao ; Sun, Yan ; Zhang, Shihua ; Chen, Yongjie ; Wu, Haixu ; Su, Bing ; Yuan, Jiamiao ; Liu, Xingyan ; Zeng, Xuerui ; Liu, Na ; Guo, Yongbo ; Liu, Yan ; Luo, Wenhao ; Dong, Kangning

The anterior cingulate cortex (ACC) of the human brain is involved in higher-level cognitive functions such as emotion and self-awareness. We generated profiles of human and macaque ACC gene expression and chromatin accessibility at single-nucleus resolution. We characterized the conserved patterns of gene expression, chromatin accessibility, and transcription factor binding in different cell types. Combining the published mouse data, we discovered the molecular identities and cell-lineage origin of the primate von Economo neurons (VENs). Our in vitro and in vivo experiments identified a group of primate-shared and human-specific VEN marker genes, such as PCSK6, ADAMTSL3, and CDHR3, potentially contributing to VEN morphogenesis. We demonstrated that the human-specific sequence changes account for the cellular and functional innovations in the ACC during primate evolution and human origin. These findings provide new insights into understanding the cellular composition and molecular regulation of ACC and its evolutionary role in shaping human-owned higher cognitive skills.

01 Nov 2024·International Journal of Biological Macromolecules

mRNA expression profile and prognostic values of the CDHR family genes in lung adenocarcinoma

Article

Author: Zhang, Shuai ; Yang, Xin ; Wang, Hong ; Wei, Yong ; Xiao, Sanling ; Zeng, Xiaofei ; Yuan, Xi ; Wu, Zhiqiang

Lung adenocarcinoma (LUAD), the predominant subtype of lung cancer, has a high incidence and annual mortality worldwide. Members of the cadherin-related (CDHR) family are associated with many malignant tumor types. However, their role and clinical significance in LUAD have not been clarified. We analyzed the association of CDHRs mRNA expression profiles with prognostic significance, immune infiltration, and potential biological functional signatures in several public databases. We constructed a co-expressed mRNA network, and performed an intrinsic molecular structure and function enrichment analysis. Our results showed that CDHR2 mRNA expression was upregulated in LUAD, whereas CDHR1, CDHR3, CDHR4, and CDHR5 mRNAs were downregulated. Upregulation of CDHR2 mRNA is associated with a poor prognosis in patients with LUAD. Next, the correlation between CDHR family members and immune infiltration was observed. A receiver operating characteristic curve showed that the CDHR family is valuable for diagnosing LUAD. In this study, we found that CDHR2 mRNA expression was upregulated in LUAD. Upregulation of CDHR2 mRNA was associated with a poor prognosis in patients with LUAD.

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